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Endoscopic versus Laparoscopic Full-Thickness Biopsy in the Pathological Evaluation of the Enteric Nervous System

Ohlsson, Bodil LU ; Gustafsson, Rita J. LU ; Toth, Ervin LU ; Veress, Bèla LU and Thorlacius, Henrik LU (2018) In Case Reports in Gastroenterology 12(1). p.32-40
Abstract

A full-thickness biopsy of the bowel wall is required to evaluate the enteric nervous system. A patient with aggravating gastrointestinal symptoms underwent a laparoscopic full-thickness biopsy of the ileum and, 1 year later, an endoscopic full-thickness biopsy of the sigmoid colon. Both samples showed enteric neuropathy characterized by vacuolated and enlarged neurons. The length of the myenteric plexus was greater in the endoscopic (23 mm) compared to the laparoscopic (11 mm) biopsy, with fewer tissue artefacts in the laparoscopic approach. Clinical deterioration was paralleled by enteric neuropathy with an increase in the percentage of vacuolated and enlarged enteric neurons from 24 to 35%.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Enteric dysmotility, Enteric neuropathy, Full-thickness biopsy, Gastrointestinal symptoms
in
Case Reports in Gastroenterology
volume
12
issue
1
pages
32 - 40
publisher
Karger
external identifiers
  • scopus:85041014499
  • pmid:29515343
ISSN
1662-0631
DOI
10.1159/000486390
language
English
LU publication?
yes
id
c5284bb8-f41c-4822-8f8d-41645bbf4b2c
date added to LUP
2018-02-06 15:55:42
date last changed
2020-04-08 14:28:17
@article{c5284bb8-f41c-4822-8f8d-41645bbf4b2c,
  abstract     = {<p>A full-thickness biopsy of the bowel wall is required to evaluate the enteric nervous system. A patient with aggravating gastrointestinal symptoms underwent a laparoscopic full-thickness biopsy of the ileum and, 1 year later, an endoscopic full-thickness biopsy of the sigmoid colon. Both samples showed enteric neuropathy characterized by vacuolated and enlarged neurons. The length of the myenteric plexus was greater in the endoscopic (23 mm) compared to the laparoscopic (11 mm) biopsy, with fewer tissue artefacts in the laparoscopic approach. Clinical deterioration was paralleled by enteric neuropathy with an increase in the percentage of vacuolated and enlarged enteric neurons from 24 to 35%.</p>},
  author       = {Ohlsson, Bodil and Gustafsson, Rita J. and Toth, Ervin and Veress, Bèla and Thorlacius, Henrik},
  issn         = {1662-0631},
  language     = {eng},
  month        = {01},
  number       = {1},
  pages        = {32--40},
  publisher    = {Karger},
  series       = {Case Reports in Gastroenterology},
  title        = {Endoscopic versus Laparoscopic Full-Thickness Biopsy in the Pathological Evaluation of the Enteric Nervous System},
  url          = {http://dx.doi.org/10.1159/000486390},
  doi          = {10.1159/000486390},
  volume       = {12},
  year         = {2018},
}