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Associations between physical activity and autonomic function during deep breathing test : the Swedish CArdioPulmonary bioImage Study (SCAPIS)

Memarian, Ensieh LU ; Kharraziha, Isabella LU orcid ; Hamrefors, Viktor LU orcid ; Platonov, Pyotr G LU ; Ekblom, Örjan ; Gottsäter, Anders LU and Engström, Gunnar LU (2023) In Clinical autonomic research : official journal of the Clinical Autonomic Research Society 33(4). p.411-420
Abstract

PURPOSE: The deep breathing test (DBT) is a sensitive test of cardiovagal function. The aim of this study was to explore associations between physical activity and sedentary time, measured by accelerometer, and autonomic function, using DBT.

METHODS: In the Swedish Cardio-Pulmonary bioImage Study, men and women aged 50-64 were randomly invited from the general population. A total of 4325 subjects who underwent DBT and assessment of physical activity and sedentary time by accelerometery were included. ECG files from 1-min DBT were used to calculate measures of respiratory sinus arrhythmia [RSA; expiration-inspiration (E-I) difference and E/I ratio], heart rate variability [HRV; root mean square of successive differences (RMSSD),... (More)

PURPOSE: The deep breathing test (DBT) is a sensitive test of cardiovagal function. The aim of this study was to explore associations between physical activity and sedentary time, measured by accelerometer, and autonomic function, using DBT.

METHODS: In the Swedish Cardio-Pulmonary bioImage Study, men and women aged 50-64 were randomly invited from the general population. A total of 4325 subjects who underwent DBT and assessment of physical activity and sedentary time by accelerometery were included. ECG files from 1-min DBT were used to calculate measures of respiratory sinus arrhythmia [RSA; expiration-inspiration (E-I) difference and E/I ratio], heart rate variability [HRV; root mean square of successive differences (RMSSD), standard deviation of heart rates and mean circular resultant]. Low RSA and HRV was defined as the lowest 10% in the population.

RESULTS: For accelerometer-assessed physical activity, there were significant associations between high percentage of sedentary time and low E/I (p < 0.01), and low RMSSD (p < 0.01) in an age- and sex-adjusted model, and between percentage of sedentary time and low RMSSD (p = 0.04) in a risk factor-adjusted model. Low RMSSD was less common in those with a high percentage of moderate to vigorous physical activity (p = 0.04, after risk-factor adjustment). These associations became non-significant when further adjusting for heart rate.

CONCLUSION: We report associations between degree of physical activity and indices of autonomic dysfunction in a large population. The relationships were no longer significant after adjustments for heart rate, indicating that the relationship between physical activity and cardiovagal function partly is accounted for by reduced heart rate.

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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Female, Humans, Male, Exercise/physiology, Heart, Heart Rate/physiology, Respiratory Sinus Arrhythmia/physiology, Sweden/epidemiology, Middle Aged
in
Clinical autonomic research : official journal of the Clinical Autonomic Research Society
volume
33
issue
4
pages
411 - 420
publisher
Springer
external identifiers
  • scopus:85162212234
  • pmid:37344567
ISSN
1619-1560
DOI
10.1007/s10286-023-00960-y
language
English
LU publication?
yes
id
c5c7f968-9685-48cb-8000-aeee50ce5aa8
date added to LUP
2023-08-31 09:07:22
date last changed
2024-04-20 02:16:49
@article{c5c7f968-9685-48cb-8000-aeee50ce5aa8,
  abstract     = {{<p>PURPOSE: The deep breathing test (DBT) is a sensitive test of cardiovagal function. The aim of this study was to explore associations between physical activity and sedentary time, measured by accelerometer, and autonomic function, using DBT.</p><p>METHODS: In the Swedish Cardio-Pulmonary bioImage Study, men and women aged 50-64 were randomly invited from the general population. A total of 4325 subjects who underwent DBT and assessment of physical activity and sedentary time by accelerometery were included. ECG files from 1-min DBT were used to calculate measures of respiratory sinus arrhythmia [RSA; expiration-inspiration (E-I) difference and E/I ratio], heart rate variability [HRV; root mean square of successive differences (RMSSD), standard deviation of heart rates and mean circular resultant]. Low RSA and HRV was defined as the lowest 10% in the population.</p><p>RESULTS: For accelerometer-assessed physical activity, there were significant associations between high percentage of sedentary time and low E/I (p &lt; 0.01), and low RMSSD (p &lt; 0.01) in an age- and sex-adjusted model, and between percentage of sedentary time and low RMSSD (p = 0.04) in a risk factor-adjusted model. Low RMSSD was less common in those with a high percentage of moderate to vigorous physical activity (p = 0.04, after risk-factor adjustment). These associations became non-significant when further adjusting for heart rate.</p><p>CONCLUSION: We report associations between degree of physical activity and indices of autonomic dysfunction in a large population. The relationships were no longer significant after adjustments for heart rate, indicating that the relationship between physical activity and cardiovagal function partly is accounted for by reduced heart rate.</p>}},
  author       = {{Memarian, Ensieh and Kharraziha, Isabella and Hamrefors, Viktor and Platonov, Pyotr G and Ekblom, Örjan and Gottsäter, Anders and Engström, Gunnar}},
  issn         = {{1619-1560}},
  keywords     = {{Female; Humans; Male; Exercise/physiology; Heart; Heart Rate/physiology; Respiratory Sinus Arrhythmia/physiology; Sweden/epidemiology; Middle Aged}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{411--420}},
  publisher    = {{Springer}},
  series       = {{Clinical autonomic research : official journal of the Clinical Autonomic Research Society}},
  title        = {{Associations between physical activity and autonomic function during deep breathing test : the Swedish CArdioPulmonary bioImage Study (SCAPIS)}},
  url          = {{http://dx.doi.org/10.1007/s10286-023-00960-y}},
  doi          = {{10.1007/s10286-023-00960-y}},
  volume       = {{33}},
  year         = {{2023}},
}