Normal frequency of structural chromosome aberrations in fibroblasts from patients with non‐Hodgkin's lymphoma
(1988) In Hereditas 109(2). p.277-280- Abstract
The incidence of chromosome aberrations, i.e., chromatid and chromosome gaps, breaks, and exchanges, was studied in cultured skin fibroblasts from 25 untreated patients with non‐Hodgkin's lymphoma (NHL) and 26 controls. The mean frequencies of aberrant cells, and gap, break, and gap+break events per 100 metaphases were 4.2, 1.9, 2.8, and 4.7 in the NHL group, and 5.1, 2.6, 3.2, and 5.8 in the control group. None of these parameters differed significantly between the groups, indicating that constitutional chromosomal instability is not related to the development of NHL. In the total material there was a significant (P<0.05) increase with age in the number of aberrant cells.
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https://lup.lub.lu.se/record/c76ffa6d-89a4-4c4f-a5fe-a85225533726
- author
- JOHANSSON, BERTIL LU ; MERTENS, FREDRIK LU ; HEIM, SVERRE LU ; KRISTOFFERSSON, ULF LU ; MANDAHL, NILS LU ; OLSSON, HÅKAN LU and MITELMAN, FELIX LU
- organization
- publishing date
- 1988-01-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Hereditas
- volume
- 109
- issue
- 2
- pages
- 277 - 280
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:3230028
- scopus:0024229155
- ISSN
- 0018-0661
- DOI
- 10.1111/j.1601-5223.1988.tb00365.x
- language
- English
- LU publication?
- yes
- id
- c76ffa6d-89a4-4c4f-a5fe-a85225533726
- date added to LUP
- 2018-12-17 17:01:38
- date last changed
- 2024-01-15 10:05:58
@article{c76ffa6d-89a4-4c4f-a5fe-a85225533726, abstract = {{<p>The incidence of chromosome aberrations, i.e., chromatid and chromosome gaps, breaks, and exchanges, was studied in cultured skin fibroblasts from 25 untreated patients with non‐Hodgkin's lymphoma (NHL) and 26 controls. The mean frequencies of aberrant cells, and gap, break, and gap+break events per 100 metaphases were 4.2, 1.9, 2.8, and 4.7 in the NHL group, and 5.1, 2.6, 3.2, and 5.8 in the control group. None of these parameters differed significantly between the groups, indicating that constitutional chromosomal instability is not related to the development of NHL. In the total material there was a significant (P<0.05) increase with age in the number of aberrant cells.</p>}}, author = {{JOHANSSON, BERTIL and MERTENS, FREDRIK and HEIM, SVERRE and KRISTOFFERSSON, ULF and MANDAHL, NILS and OLSSON, HÅKAN and MITELMAN, FELIX}}, issn = {{0018-0661}}, language = {{eng}}, month = {{01}}, number = {{2}}, pages = {{277--280}}, publisher = {{Wiley-Blackwell}}, series = {{Hereditas}}, title = {{Normal frequency of structural chromosome aberrations in fibroblasts from patients with non‐Hodgkin's lymphoma}}, url = {{http://dx.doi.org/10.1111/j.1601-5223.1988.tb00365.x}}, doi = {{10.1111/j.1601-5223.1988.tb00365.x}}, volume = {{109}}, year = {{1988}}, }