Antibody kinetics and clinical course of COVID-19 a prospective observational study
Bläckberg, Anna LU ; Fernström, Nils ; Sarbrant, Emma ; Rasmussen, Magnus LU
and Sunnerhagen, Torgny
LU
(2021)
In PLoS ONE
16(3 March).
- Abstract
Background Serological response and association to clinical manifestation is important for understanding the pathogenesis of COVID-19. Materials and methods A prospective observational study was conducted where antibody responses of IgG and IgA towards SARS-CoV-2 spike protein were studied over time in patients with COVID-19. Possible associations between antibody titers and outcome were analyzed. Results Forty patients with COVID-19, hospitalized at Skåne University hospital, Sweden, between April and June 2020 were included. IgG antibody responses were detected for all patients with the highest levels four weeks after COVID-19 diagnosis. Levels of IgA were generally higher at diagnosis and decreased towards baseline 4 weeks after... (More)
Background Serological response and association to clinical manifestation is important for understanding the pathogenesis of COVID-19. Materials and methods A prospective observational study was conducted where antibody responses of IgG and IgA towards SARS-CoV-2 spike protein were studied over time in patients with COVID-19. Possible associations between antibody titers and outcome were analyzed. Results Forty patients with COVID-19, hospitalized at Skåne University hospital, Sweden, between April and June 2020 were included. IgG antibody responses were detected for all patients with the highest levels four weeks after COVID-19 diagnosis. Levels of IgA were generally higher at diagnosis and decreased towards baseline 4 weeks after confirmed COVID-19. Patients with severe COVID-19 had higher levels of antibodies directed against SARS-CoV- 2 spike protein compared with patients with mild disease. Conclusion IgG and IgA antibodies towards the spike protein follow different kinetics during COVID-19 and patients with severe disease develop higher antibody levels.
(Less)
- author
- Bläckberg, Anna
LU
; Fernström, Nils
; Sarbrant, Emma
; Rasmussen, Magnus
LU
and Sunnerhagen, Torgny
LU
- organization
- publishing date
- 2021
- type
- Contribution to journal
- publication status
- published
- subject
- in
- PLoS ONE
- volume
- 16
- issue
- 3 March
- article number
- e0248918
- publisher
- Public Library of Science (PLoS)
- external identifiers
-
- pmid:33750984
- scopus:85103152145
- ISSN
- 1932-6203
- DOI
- 10.1371/journal.pone.0248918
- project
- Antikroppar och patientkarakteristika vid COVID-19
- language
- English
- LU publication?
- yes
- id
- c8524964-64c0-4079-a591-8bdcb1f93fca
- date added to LUP
- 2021-04-08 08:46:38
- date last changed
- 2025-03-10 14:41:24
@article{c8524964-64c0-4079-a591-8bdcb1f93fca,
abstract = {{<p>Background Serological response and association to clinical manifestation is important for understanding the pathogenesis of COVID-19. Materials and methods A prospective observational study was conducted where antibody responses of IgG and IgA towards SARS-CoV-2 spike protein were studied over time in patients with COVID-19. Possible associations between antibody titers and outcome were analyzed. Results Forty patients with COVID-19, hospitalized at Skåne University hospital, Sweden, between April and June 2020 were included. IgG antibody responses were detected for all patients with the highest levels four weeks after COVID-19 diagnosis. Levels of IgA were generally higher at diagnosis and decreased towards baseline 4 weeks after confirmed COVID-19. Patients with severe COVID-19 had higher levels of antibodies directed against SARS-CoV- 2 spike protein compared with patients with mild disease. Conclusion IgG and IgA antibodies towards the spike protein follow different kinetics during COVID-19 and patients with severe disease develop higher antibody levels. </p>}},
author = {{Bläckberg, Anna and Fernström, Nils and Sarbrant, Emma and Rasmussen, Magnus and Sunnerhagen, Torgny}},
issn = {{1932-6203}},
language = {{eng}},
number = {{3 March}},
publisher = {{Public Library of Science (PLoS)}},
series = {{PLoS ONE}},
title = {{Antibody kinetics and clinical course of COVID-19 a prospective observational study}},
url = {{https://lup.lub.lu.se/search/files/119180276/Antibody_kinetics_and_clinical_course_of_COVID_19_a_prospective_observational_study.pdf}},
doi = {{10.1371/journal.pone.0248918}},
volume = {{16}},
year = {{2021}},
}