Associations between Th1-related cytokines and complicated pediatric appendicitis
(2024) In Scientific Reports 14(1).- Abstract
- The pathogenesis of appendicitis is not understood fully, and the diagnosis can be challenging. Previous research has suggested an association between a T helper (Th) 1-dependent immune response and complicated appendicitis. This prospective cohort study aimed to evaluate the association between serum concentrations of the Th1-associated cytokines interleukin (IL)-1α, IL-1β, IL-2, IL-6, IL-10, IL-17A and tumor necrosis factor beta (TNF-β) and the risk of complicated appendicitis in children. Appendicitis severity was determined through histopathological examination. A total of 137 children < 15 years with appendicitis were included with a median age of 10 years (IQR 8-12); 86 (63%) were boys, and 58 (42%) had complicated appendicitis.... (More)
- The pathogenesis of appendicitis is not understood fully, and the diagnosis can be challenging. Previous research has suggested an association between a T helper (Th) 1-dependent immune response and complicated appendicitis. This prospective cohort study aimed to evaluate the association between serum concentrations of the Th1-associated cytokines interleukin (IL)-1α, IL-1β, IL-2, IL-6, IL-10, IL-17A and tumor necrosis factor beta (TNF-β) and the risk of complicated appendicitis in children. Appendicitis severity was determined through histopathological examination. A total of 137 children < 15 years with appendicitis were included with a median age of 10 years (IQR 8-12); 86 (63%) were boys, and 58 (42%) had complicated appendicitis. Children with complicated appendicitis had significantly higher concentrations of serum IL-6 and IL-10, and lower of TNF-β. After adjustment for age, symptom duration, and presence of appendicolith in a multivariable logistic regression, a higher concentration of IL-6 remained associated with an increased risk of complicated appendicitis (aOR 1.001 [95% CI 1.000-1.002], p = 0.02). Serum concentrations of IL-1α, IL-1β, IL-2, IL-10, IL-17A and TNF-β were not significantly associated with the risk of complicated appendicitis. In conclusion, our results suggests that the systemic inflammatory response in complicated appendicitis is complex and not solely Th1-dependent. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/c934f8b1-d606-4670-8da0-01e5b44ee126
- author
- Elliver, Matilda LU ; Salö, Martin LU ; Roth, Bodil LU ; Ohlsson, Bodil LU ; Hagander, Lars LU and Gudjonsdottir, Johanna LU
- organization
-
- Paediatrics (Lund)
- Department of Clinical Sciences, Lund
- Pediatric surgery (research group)
- Gastroenterology (research group)
- Department of Clinical Sciences, Malmö
- Internal Medicine - Epidemiology (research group)
- Birgit Rausing Centre for Medical Humanities (BRCMH)
- Surgery and public health (research group)
- publishing date
- 2024
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Acute inflammation, Diagnostic markers, Gastrointestinal system, Paediatric research, Predictive markers
- in
- Scientific Reports
- volume
- 14
- issue
- 1
- article number
- 4613
- pages
- 8 pages
- publisher
- Nature Publishing Group
- external identifiers
-
- pmid:38409170
- scopus:85185916052
- ISSN
- 2045-2322
- DOI
- 10.1038/s41598-024-53756-z
- language
- English
- LU publication?
- yes
- id
- c934f8b1-d606-4670-8da0-01e5b44ee126
- date added to LUP
- 2024-03-04 09:11:42
- date last changed
- 2024-03-05 09:10:24
@article{c934f8b1-d606-4670-8da0-01e5b44ee126, abstract = {{The pathogenesis of appendicitis is not understood fully, and the diagnosis can be challenging. Previous research has suggested an association between a T helper (Th) 1-dependent immune response and complicated appendicitis. This prospective cohort study aimed to evaluate the association between serum concentrations of the Th1-associated cytokines interleukin (IL)-1α, IL-1β, IL-2, IL-6, IL-10, IL-17A and tumor necrosis factor beta (TNF-β) and the risk of complicated appendicitis in children. Appendicitis severity was determined through histopathological examination. A total of 137 children < 15 years with appendicitis were included with a median age of 10 years (IQR 8-12); 86 (63%) were boys, and 58 (42%) had complicated appendicitis. Children with complicated appendicitis had significantly higher concentrations of serum IL-6 and IL-10, and lower of TNF-β. After adjustment for age, symptom duration, and presence of appendicolith in a multivariable logistic regression, a higher concentration of IL-6 remained associated with an increased risk of complicated appendicitis (aOR 1.001 [95% CI 1.000-1.002], p = 0.02). Serum concentrations of IL-1α, IL-1β, IL-2, IL-10, IL-17A and TNF-β were not significantly associated with the risk of complicated appendicitis. In conclusion, our results suggests that the systemic inflammatory response in complicated appendicitis is complex and not solely Th1-dependent.}}, author = {{Elliver, Matilda and Salö, Martin and Roth, Bodil and Ohlsson, Bodil and Hagander, Lars and Gudjonsdottir, Johanna}}, issn = {{2045-2322}}, keywords = {{Acute inflammation; Diagnostic markers; Gastrointestinal system; Paediatric research; Predictive markers}}, language = {{eng}}, number = {{1}}, publisher = {{Nature Publishing Group}}, series = {{Scientific Reports}}, title = {{Associations between Th1-related cytokines and complicated pediatric appendicitis}}, url = {{http://dx.doi.org/10.1038/s41598-024-53756-z}}, doi = {{10.1038/s41598-024-53756-z}}, volume = {{14}}, year = {{2024}}, }