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Associations between Th1-related cytokines and complicated pediatric appendicitis

Elliver, Matilda LU ; Salö, Martin LU ; Roth, Bodil LU ; Ohlsson, Bodil LU ; Hagander, Lars LU orcid and Gudjonsdottir, Johanna LU (2024) In Scientific Reports 14(1).
Abstract
The pathogenesis of appendicitis is not understood fully, and the diagnosis can be challenging. Previous research has suggested an association between a T helper (Th) 1-dependent immune response and complicated appendicitis. This prospective cohort study aimed to evaluate the association between serum concentrations of the Th1-associated cytokines interleukin (IL)-1α, IL-1β, IL-2, IL-6, IL-10, IL-17A and tumor necrosis factor beta (TNF-β) and the risk of complicated appendicitis in children. Appendicitis severity was determined through histopathological examination. A total of 137 children < 15 years with appendicitis were included with a median age of 10 years (IQR 8-12); 86 (63%) were boys, and 58 (42%) had complicated appendicitis.... (More)
The pathogenesis of appendicitis is not understood fully, and the diagnosis can be challenging. Previous research has suggested an association between a T helper (Th) 1-dependent immune response and complicated appendicitis. This prospective cohort study aimed to evaluate the association between serum concentrations of the Th1-associated cytokines interleukin (IL)-1α, IL-1β, IL-2, IL-6, IL-10, IL-17A and tumor necrosis factor beta (TNF-β) and the risk of complicated appendicitis in children. Appendicitis severity was determined through histopathological examination. A total of 137 children < 15 years with appendicitis were included with a median age of 10 years (IQR 8-12); 86 (63%) were boys, and 58 (42%) had complicated appendicitis. Children with complicated appendicitis had significantly higher concentrations of serum IL-6 and IL-10, and lower of TNF-β. After adjustment for age, symptom duration, and presence of appendicolith in a multivariable logistic regression, a higher concentration of IL-6 remained associated with an increased risk of complicated appendicitis (aOR 1.001 [95% CI 1.000-1.002], p = 0.02). Serum concentrations of IL-1α, IL-1β, IL-2, IL-10, IL-17A and TNF-β were not significantly associated with the risk of complicated appendicitis. In conclusion, our results suggests that the systemic inflammatory response in complicated appendicitis is complex and not solely Th1-dependent. (Less)
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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Acute inflammation, Diagnostic markers, Gastrointestinal system, Paediatric research, Predictive markers
in
Scientific Reports
volume
14
issue
1
article number
4613
pages
8 pages
publisher
Nature Publishing Group
external identifiers
  • pmid:38409170
  • scopus:85185916052
ISSN
2045-2322
DOI
10.1038/s41598-024-53756-z
language
English
LU publication?
yes
id
c934f8b1-d606-4670-8da0-01e5b44ee126
date added to LUP
2024-03-04 09:11:42
date last changed
2025-10-14 09:55:51
@article{c934f8b1-d606-4670-8da0-01e5b44ee126,
  abstract     = {{The pathogenesis of appendicitis is not understood fully, and the diagnosis can be challenging. Previous research has suggested an association between a T helper (Th) 1-dependent immune response and complicated appendicitis. This prospective cohort study aimed to evaluate the association between serum concentrations of the Th1-associated cytokines interleukin (IL)-1α, IL-1β, IL-2, IL-6, IL-10, IL-17A and tumor necrosis factor beta (TNF-β) and the risk of complicated appendicitis in children. Appendicitis severity was determined through histopathological examination. A total of 137 children &lt; 15 years with appendicitis were included with a median age of 10 years (IQR 8-12); 86 (63%) were boys, and 58 (42%) had complicated appendicitis. Children with complicated appendicitis had significantly higher concentrations of serum IL-6 and IL-10, and lower of TNF-β. After adjustment for age, symptom duration, and presence of appendicolith in a multivariable logistic regression, a higher concentration of IL-6 remained associated with an increased risk of complicated appendicitis (aOR 1.001 [95% CI 1.000-1.002], p = 0.02). Serum concentrations of IL-1α, IL-1β, IL-2, IL-10, IL-17A and TNF-β were not significantly associated with the risk of complicated appendicitis. In conclusion, our results suggests that the systemic inflammatory response in complicated appendicitis is complex and not solely Th1-dependent.}},
  author       = {{Elliver, Matilda and Salö, Martin and Roth, Bodil and Ohlsson, Bodil and Hagander, Lars and Gudjonsdottir, Johanna}},
  issn         = {{2045-2322}},
  keywords     = {{Acute inflammation; Diagnostic markers; Gastrointestinal system; Paediatric research; Predictive markers}},
  language     = {{eng}},
  number       = {{1}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Scientific Reports}},
  title        = {{Associations between Th1-related cytokines and complicated pediatric appendicitis}},
  url          = {{http://dx.doi.org/10.1038/s41598-024-53756-z}},
  doi          = {{10.1038/s41598-024-53756-z}},
  volume       = {{14}},
  year         = {{2024}},
}