The evaluation of an electrocardiographic myocardial ischemia acuteness score to predict the amount of myocardial salvage achieved by early percutaneous coronary intervention Clinical validation with myocardial perfusion single photon emission computed tomography and cardiac magnetic resonance.
Engblom, Henrik LU ; Strauss, David G LU ; Hedén, Bo LU ; Hedström, Erik LU
; Jovinge, Stefan
LU
; Götberg, Matthias
LU
; Erlinge, David
LU
; Wagner, Galen S
and Arheden, Håkan
LU
(2011)
In Journal of Electrocardiology
44.
p.525-532
- Abstract
- BACKGROUND: The time from symptom onset to reperfusion in acute myocardial infarction (MI) has been shown to be a poor predictor of patient outcome. Acute electrocardiographic (ECG) changes, however, have been shown useful for estimated acuteness of myocardial ischemia using the Anderson-Wilkins ECG ischemia acuteness score (AW-acuteness score). The aim was to study whether acute ischemic ECG changes can predict the amount of salvageable myocardium in patients with acute ST-elevation MI. METHODS: Thirty-eight patients treated with primary percutaneous coronary intervention for first-time ST-elevation MI were retrospectively enrolled. Myocardium at risk (MaR) was determined by myocardial perfusion single photon emission computed tomography... (More)
- BACKGROUND: The time from symptom onset to reperfusion in acute myocardial infarction (MI) has been shown to be a poor predictor of patient outcome. Acute electrocardiographic (ECG) changes, however, have been shown useful for estimated acuteness of myocardial ischemia using the Anderson-Wilkins ECG ischemia acuteness score (AW-acuteness score). The aim was to study whether acute ischemic ECG changes can predict the amount of salvageable myocardium in patients with acute ST-elevation MI. METHODS: Thirty-eight patients treated with primary percutaneous coronary intervention for first-time ST-elevation MI were retrospectively enrolled. Myocardium at risk (MaR) was determined by myocardial perfusion single photon emission computed tomography acutely or by T2-weighted cardiac magnetic resonance after 1 week, at the same time when final MI size was determined by late gadolinium enhancement. Myocardial salvage was calculated as (MaR - MI size)/MaR and compared with AW-acuteness score and time from symptom onset to primary percutaneous coronary intervention. RESULTS: The AW-acuteness score correlated significantly with salvageable myocardium for right coronary artery (RCA) occlusions (r = -0.57; P = .02) but not for left anterior descending artery (LAD) occlusions (r = -0.04; P = .88). Time from symptom onset did not correlate with the amount of salvageable myocardium (LAD, r = 0.04 and P = .87; RCA, r = -0.40 and P = .13). CONCLUSIONS: There is a moderate correlation between AW-acuteness score and salvageable myocardium in patients with acute RCA occlusion but not in patients with LAD occlusion. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2008250
- author
- Engblom, Henrik
LU
; Strauss, David G
LU
; Hedén, Bo
LU
; Hedström, Erik
LU
; Jovinge, Stefan
LU
; Götberg, Matthias
LU
; Erlinge, David
LU
; Wagner, Galen S
and Arheden, Håkan
LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Electrocardiology
- volume
- 44
- pages
- 525 - 532
- publisher
- Elsevier
- external identifiers
-
- wos:000294742000007
- pmid:21658711
- scopus:80052149880
- pmid:21658711
- ISSN
- 1532-8430
- DOI
- 10.1016/j.jelectrocard.2011.03.008
- language
- English
- LU publication?
- yes
- id
- ca8e9d40-6853-4c49-9a06-250eafce2673 (old id 2008250)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/21658711?dopt=Abstract
- date added to LUP
- 2016-04-04 08:12:28
- date last changed
- 2023-01-29 01:48:39
@article{ca8e9d40-6853-4c49-9a06-250eafce2673,
abstract = {{BACKGROUND: The time from symptom onset to reperfusion in acute myocardial infarction (MI) has been shown to be a poor predictor of patient outcome. Acute electrocardiographic (ECG) changes, however, have been shown useful for estimated acuteness of myocardial ischemia using the Anderson-Wilkins ECG ischemia acuteness score (AW-acuteness score). The aim was to study whether acute ischemic ECG changes can predict the amount of salvageable myocardium in patients with acute ST-elevation MI. METHODS: Thirty-eight patients treated with primary percutaneous coronary intervention for first-time ST-elevation MI were retrospectively enrolled. Myocardium at risk (MaR) was determined by myocardial perfusion single photon emission computed tomography acutely or by T2-weighted cardiac magnetic resonance after 1 week, at the same time when final MI size was determined by late gadolinium enhancement. Myocardial salvage was calculated as (MaR - MI size)/MaR and compared with AW-acuteness score and time from symptom onset to primary percutaneous coronary intervention. RESULTS: The AW-acuteness score correlated significantly with salvageable myocardium for right coronary artery (RCA) occlusions (r = -0.57; P = .02) but not for left anterior descending artery (LAD) occlusions (r = -0.04; P = .88). Time from symptom onset did not correlate with the amount of salvageable myocardium (LAD, r = 0.04 and P = .87; RCA, r = -0.40 and P = .13). CONCLUSIONS: There is a moderate correlation between AW-acuteness score and salvageable myocardium in patients with acute RCA occlusion but not in patients with LAD occlusion.}},
author = {{Engblom, Henrik and Strauss, David G and Hedén, Bo and Hedström, Erik and Jovinge, Stefan and Götberg, Matthias and Erlinge, David and Wagner, Galen S and Arheden, Håkan}},
issn = {{1532-8430}},
language = {{eng}},
pages = {{525--532}},
publisher = {{Elsevier}},
series = {{Journal of Electrocardiology}},
title = {{The evaluation of an electrocardiographic myocardial ischemia acuteness score to predict the amount of myocardial salvage achieved by early percutaneous coronary intervention Clinical validation with myocardial perfusion single photon emission computed tomography and cardiac magnetic resonance.}},
url = {{http://dx.doi.org/10.1016/j.jelectrocard.2011.03.008}},
doi = {{10.1016/j.jelectrocard.2011.03.008}},
volume = {{44}},
year = {{2011}},
}