Blood and hair manganese concentrations in pregnant women from the Infants' Environmental Health Study (ISA) in Costa Rica
(2014) In Environmental Science and Technology 48(6). p.3467-3476- Abstract
Manganese (Mn), an essential nutrient, is a neurotoxicant at high concentrations. We measured Mn concentrations in repeated blood and hair samples collected from 449 pregnant women living near banana plantations with extensive aerial spraying of Mn-containing fungicide mancozeb in Costa Rica, and examined environmental and lifestyle factors associated with these biomarkers. Mean blood Mn and geometric mean hair Mn concentrations were 24.4 μg/L (8.9-56.3) and 1.8 μg/g (0.05-53.3), respectively. Blood Mn concentrations were positively associated with gestational age at sampling (β = 0.2; 95% CI: 0.1 to 0.2), number of household members (β = 0.4; 95% CI: 0.1 to 0.6), and living in a house made of permeable and difficult-to-clean materials... (More)
Manganese (Mn), an essential nutrient, is a neurotoxicant at high concentrations. We measured Mn concentrations in repeated blood and hair samples collected from 449 pregnant women living near banana plantations with extensive aerial spraying of Mn-containing fungicide mancozeb in Costa Rica, and examined environmental and lifestyle factors associated with these biomarkers. Mean blood Mn and geometric mean hair Mn concentrations were 24.4 μg/L (8.9-56.3) and 1.8 μg/g (0.05-53.3), respectively. Blood Mn concentrations were positively associated with gestational age at sampling (β = 0.2; 95% CI: 0.1 to 0.2), number of household members (β = 0.4; 95% CI: 0.1 to 0.6), and living in a house made of permeable and difficult-to-clean materials (β = 2.6; 95% CI: 1.3 to 4.0); and inversely related to smoking (β = -3.1; 95% CI: -5.8 to -0.3). Hair Mn concentrations were inversely associated with gestational age at sampling (% change = 0.8; 95% CI: -1.6 to 0.0); and positively associated with living within 50 m of a plantation (% change = 42.1; 95% CI: 14.2 to 76.9) and Mn concentrations in drinking water (% change = 17.5; 95% CI: 12.2 to 22.8). Our findings suggest that pregnant women living near banana plantations aerially sprayed with mancozeb may be environmentally exposed to Mn.
(Less)
- author
- organization
- publishing date
- 2014-03-18
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Environmental Science and Technology
- volume
- 48
- issue
- 6
- pages
- 3467 - 3476
- publisher
- The American Chemical Society (ACS)
- external identifiers
-
- pmid:24601641
- scopus:84898941033
- ISSN
- 0013-936X
- DOI
- 10.1021/es404279r
- language
- English
- LU publication?
- yes
- id
- cbc7b2b1-39db-4fe1-9698-61d3f9f53d5d
- date added to LUP
- 2023-09-26 10:33:08
- date last changed
- 2024-04-04 23:24:13
@article{cbc7b2b1-39db-4fe1-9698-61d3f9f53d5d, abstract = {{<p>Manganese (Mn), an essential nutrient, is a neurotoxicant at high concentrations. We measured Mn concentrations in repeated blood and hair samples collected from 449 pregnant women living near banana plantations with extensive aerial spraying of Mn-containing fungicide mancozeb in Costa Rica, and examined environmental and lifestyle factors associated with these biomarkers. Mean blood Mn and geometric mean hair Mn concentrations were 24.4 μg/L (8.9-56.3) and 1.8 μg/g (0.05-53.3), respectively. Blood Mn concentrations were positively associated with gestational age at sampling (β = 0.2; 95% CI: 0.1 to 0.2), number of household members (β = 0.4; 95% CI: 0.1 to 0.6), and living in a house made of permeable and difficult-to-clean materials (β = 2.6; 95% CI: 1.3 to 4.0); and inversely related to smoking (β = -3.1; 95% CI: -5.8 to -0.3). Hair Mn concentrations were inversely associated with gestational age at sampling (% change = 0.8; 95% CI: -1.6 to 0.0); and positively associated with living within 50 m of a plantation (% change = 42.1; 95% CI: 14.2 to 76.9) and Mn concentrations in drinking water (% change = 17.5; 95% CI: 12.2 to 22.8). Our findings suggest that pregnant women living near banana plantations aerially sprayed with mancozeb may be environmentally exposed to Mn.</p>}}, author = {{Mora, Ana M. and Van Wendel De Joode, Berna and Mergler, Donna and Córdoba, Leonel and Cano, Camilo and Quesada, Rosario and Smith, Donald R. and Menezes-Filho, José A. and Lundh, Thomas and Lindh, Christian H. and Bradman, Asa and Eskenazi, Brenda}}, issn = {{0013-936X}}, language = {{eng}}, month = {{03}}, number = {{6}}, pages = {{3467--3476}}, publisher = {{The American Chemical Society (ACS)}}, series = {{Environmental Science and Technology}}, title = {{Blood and hair manganese concentrations in pregnant women from the Infants' Environmental Health Study (ISA) in Costa Rica}}, url = {{http://dx.doi.org/10.1021/es404279r}}, doi = {{10.1021/es404279r}}, volume = {{48}}, year = {{2014}}, }