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Blood and hair manganese concentrations in pregnant women from the Infants' Environmental Health Study (ISA) in Costa Rica

Mora, Ana M. ; Van Wendel De Joode, Berna ; Mergler, Donna ; Córdoba, Leonel ; Cano, Camilo ; Quesada, Rosario ; Smith, Donald R. ; Menezes-Filho, José A. ; Lundh, Thomas LU and Lindh, Christian H. LU orcid , et al. (2014) In Environmental Science and Technology 48(6). p.3467-3476
Abstract

Manganese (Mn), an essential nutrient, is a neurotoxicant at high concentrations. We measured Mn concentrations in repeated blood and hair samples collected from 449 pregnant women living near banana plantations with extensive aerial spraying of Mn-containing fungicide mancozeb in Costa Rica, and examined environmental and lifestyle factors associated with these biomarkers. Mean blood Mn and geometric mean hair Mn concentrations were 24.4 μg/L (8.9-56.3) and 1.8 μg/g (0.05-53.3), respectively. Blood Mn concentrations were positively associated with gestational age at sampling (β = 0.2; 95% CI: 0.1 to 0.2), number of household members (β = 0.4; 95% CI: 0.1 to 0.6), and living in a house made of permeable and difficult-to-clean materials... (More)

Manganese (Mn), an essential nutrient, is a neurotoxicant at high concentrations. We measured Mn concentrations in repeated blood and hair samples collected from 449 pregnant women living near banana plantations with extensive aerial spraying of Mn-containing fungicide mancozeb in Costa Rica, and examined environmental and lifestyle factors associated with these biomarkers. Mean blood Mn and geometric mean hair Mn concentrations were 24.4 μg/L (8.9-56.3) and 1.8 μg/g (0.05-53.3), respectively. Blood Mn concentrations were positively associated with gestational age at sampling (β = 0.2; 95% CI: 0.1 to 0.2), number of household members (β = 0.4; 95% CI: 0.1 to 0.6), and living in a house made of permeable and difficult-to-clean materials (β = 2.6; 95% CI: 1.3 to 4.0); and inversely related to smoking (β = -3.1; 95% CI: -5.8 to -0.3). Hair Mn concentrations were inversely associated with gestational age at sampling (% change = 0.8; 95% CI: -1.6 to 0.0); and positively associated with living within 50 m of a plantation (% change = 42.1; 95% CI: 14.2 to 76.9) and Mn concentrations in drinking water (% change = 17.5; 95% CI: 12.2 to 22.8). Our findings suggest that pregnant women living near banana plantations aerially sprayed with mancozeb may be environmentally exposed to Mn.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Environmental Science and Technology
volume
48
issue
6
pages
3467 - 3476
publisher
The American Chemical Society (ACS)
external identifiers
  • pmid:24601641
  • scopus:84898941033
ISSN
0013-936X
DOI
10.1021/es404279r
language
English
LU publication?
yes
id
cbc7b2b1-39db-4fe1-9698-61d3f9f53d5d
date added to LUP
2023-09-26 10:33:08
date last changed
2024-04-04 23:24:13
@article{cbc7b2b1-39db-4fe1-9698-61d3f9f53d5d,
  abstract     = {{<p>Manganese (Mn), an essential nutrient, is a neurotoxicant at high concentrations. We measured Mn concentrations in repeated blood and hair samples collected from 449 pregnant women living near banana plantations with extensive aerial spraying of Mn-containing fungicide mancozeb in Costa Rica, and examined environmental and lifestyle factors associated with these biomarkers. Mean blood Mn and geometric mean hair Mn concentrations were 24.4 μg/L (8.9-56.3) and 1.8 μg/g (0.05-53.3), respectively. Blood Mn concentrations were positively associated with gestational age at sampling (β = 0.2; 95% CI: 0.1 to 0.2), number of household members (β = 0.4; 95% CI: 0.1 to 0.6), and living in a house made of permeable and difficult-to-clean materials (β = 2.6; 95% CI: 1.3 to 4.0); and inversely related to smoking (β = -3.1; 95% CI: -5.8 to -0.3). Hair Mn concentrations were inversely associated with gestational age at sampling (% change = 0.8; 95% CI: -1.6 to 0.0); and positively associated with living within 50 m of a plantation (% change = 42.1; 95% CI: 14.2 to 76.9) and Mn concentrations in drinking water (% change = 17.5; 95% CI: 12.2 to 22.8). Our findings suggest that pregnant women living near banana plantations aerially sprayed with mancozeb may be environmentally exposed to Mn.</p>}},
  author       = {{Mora, Ana M. and Van Wendel De Joode, Berna and Mergler, Donna and Córdoba, Leonel and Cano, Camilo and Quesada, Rosario and Smith, Donald R. and Menezes-Filho, José A. and Lundh, Thomas and Lindh, Christian H. and Bradman, Asa and Eskenazi, Brenda}},
  issn         = {{0013-936X}},
  language     = {{eng}},
  month        = {{03}},
  number       = {{6}},
  pages        = {{3467--3476}},
  publisher    = {{The American Chemical Society (ACS)}},
  series       = {{Environmental Science and Technology}},
  title        = {{Blood and hair manganese concentrations in pregnant women from the Infants' Environmental Health Study (ISA) in Costa Rica}},
  url          = {{http://dx.doi.org/10.1021/es404279r}},
  doi          = {{10.1021/es404279r}},
  volume       = {{48}},
  year         = {{2014}},
}