Impact of an Okinawa/Nordic based diet on endocrinological and periodontal conditions in individuals with type 2 diabetes. A randomized case–control study
Persson, G. Rutger ; Widén, Cecilia ; Wohlfart, Björn LU ; Sjöberg, Klas LU
; Steen, Stig
LU
; Coleman, Michael D.
and Holmer, Helene
(2023)
In BMC Oral Health
23(1).
- Abstract
Objectives: To assess if the results following intake of a diet using an Okinawan-based Nordic diet (OBND) over one month differs in endocrinological, periodontal clinical outcome, and serum cytokine levels compared to a standard hospital care diet in individuals with diabetes type 2 (T2D) (control group). Background: Scientific evidence suggests that the use of diet for individuals with T2D may be beneficial. Methods: Participating individuals with T2D were randomly assigned to a test (OBND) (n = 14), or control group (n = 16). Anthropometric data, blood glucose levels, HbA1c levels, lipids, serum inflammation markers (CRP, and a routine panel of 24 cytokines), blood pressure, gingival bleeding on probing (BOP), probing pocket depths... (More)
Objectives: To assess if the results following intake of a diet using an Okinawan-based Nordic diet (OBND) over one month differs in endocrinological, periodontal clinical outcome, and serum cytokine levels compared to a standard hospital care diet in individuals with diabetes type 2 (T2D) (control group). Background: Scientific evidence suggests that the use of diet for individuals with T2D may be beneficial. Methods: Participating individuals with T2D were randomly assigned to a test (OBND) (n = 14), or control group (n = 16). Anthropometric data, blood glucose levels, HbA1c levels, lipids, serum inflammation markers (CRP, and a routine panel of 24 cytokines), blood pressure, gingival bleeding on probing (BOP), probing pocket depths (PPD), and clinical attachment levels (CAL) were studied. Results: Statistical analyses of baseline study data failed to demonstrate study group differences. The mean weight reduction was greater in the OBND group (4.1 kg) versus the control group (1.3 kg) (p < 0.01). The reduction in BMI was 1.4 kg/m2 in OBND (p < 0.001) and 0.5 kg/m2 in the control group, respectively (p < 0.01). Diastolic and systolic blood pressure reductions were greater in the OBND group than in the control group (p < 0.01). Periodontal study parameters (BOP % scores) and (PPD values) decreased (p < 0.001) overall with no between group differences. The OBND resulted in reduction of serum levels of IFNγ, Eotaxin IL-9, IP10,IL17a, MCP-1,m and PDFBB compared to the control diet. Conclusions: A strict T2D- diet provides an association between reduction in serum HbA1c and BOP scores. Serum levels decreases in IFNγ, Eotaxin IL-9, IP-10, IL17a. MCP-1, and PDFBB were only found in the test group.
(Less)
- author
- Persson, G. Rutger
; Widén, Cecilia
; Wohlfart, Björn
LU
; Sjöberg, Klas
LU
; Steen, Stig
LU
; Coleman, Michael D.
and Holmer, Helene
- organization
- publishing date
- 2023-12
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Cytokine, Diabetes mellitus, Diet, Gingivitis, HbA1c, Periodontitis
- in
- BMC Oral Health
- volume
- 23
- issue
- 1
- article number
- 544
- publisher
- BioMed Central (BMC)
- external identifiers
-
- pmid:37553617
- scopus:85167371528
- ISSN
- 1472-6831
- DOI
- 10.1186/s12903-023-03272-9
- language
- English
- LU publication?
- yes
- id
- cbedac78-dfb9-40c2-a2ab-f19aca9b1ac8
- date added to LUP
- 2023-10-20 16:36:12
- date last changed
- 2024-04-19 02:42:49
@article{cbedac78-dfb9-40c2-a2ab-f19aca9b1ac8,
abstract = {{<p>Objectives: To assess if the results following intake of a diet using an Okinawan-based Nordic diet (OBND) over one month differs in endocrinological, periodontal clinical outcome, and serum cytokine levels compared to a standard hospital care diet in individuals with diabetes type 2 (T2D) (control group). Background: Scientific evidence suggests that the use of diet for individuals with T2D may be beneficial. Methods: Participating individuals with T2D were randomly assigned to a test (OBND) (n = 14), or control group (n = 16). Anthropometric data, blood glucose levels, HbA1c levels, lipids, serum inflammation markers (CRP, and a routine panel of 24 cytokines), blood pressure, gingival bleeding on probing (BOP), probing pocket depths (PPD), and clinical attachment levels (CAL) were studied. Results: Statistical analyses of baseline study data failed to demonstrate study group differences. The mean weight reduction was greater in the OBND group (4.1 kg) versus the control group (1.3 kg) (p < 0.01). The reduction in BMI was 1.4 kg/m2 in OBND (p < 0.001) and 0.5 kg/m2 in the control group, respectively (p < 0.01). Diastolic and systolic blood pressure reductions were greater in the OBND group than in the control group (p < 0.01). Periodontal study parameters (BOP % scores) and (PPD values) decreased (p < 0.001) overall with no between group differences. The OBND resulted in reduction of serum levels of IFNγ, Eotaxin IL-9, IP10,IL17a, MCP-1,m and PDFBB compared to the control diet. Conclusions: A strict T2D- diet provides an association between reduction in serum HbA1c and BOP scores. Serum levels decreases in IFNγ, Eotaxin IL-9, IP-10, IL17a. MCP-1, and PDFBB were only found in the test group.</p>}},
author = {{Persson, G. Rutger and Widén, Cecilia and Wohlfart, Björn and Sjöberg, Klas and Steen, Stig and Coleman, Michael D. and Holmer, Helene}},
issn = {{1472-6831}},
keywords = {{Cytokine; Diabetes mellitus; Diet; Gingivitis; HbA1c; Periodontitis}},
language = {{eng}},
number = {{1}},
publisher = {{BioMed Central (BMC)}},
series = {{BMC Oral Health}},
title = {{Impact of an Okinawa/Nordic based diet on endocrinological and periodontal conditions in individuals with type 2 diabetes. A randomized case–control study}},
url = {{http://dx.doi.org/10.1186/s12903-023-03272-9}},
doi = {{10.1186/s12903-023-03272-9}},
volume = {{23}},
year = {{2023}},
}