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Matched analysis of circulating selenium with the breast cancer selenotranscriptome: a multicentre prospective study

Demircan, Kamil ; Bengtsson, Ylva LU orcid ; Samson Chillon, Thilo ; Vallon-Christersson, Johan LU orcid ; Sun, Qian ; Larsson, Christer LU ; Malmberg, Martin ; Saal, Lao LU orcid ; Ryden, Lisa LU orcid and Borg, Åke LU , et al. (2023) In Journal of Translational Medicine
Abstract
Introduction
Low serum selenium and altered tumour RNA expression of certain selenoproteins are associated with a poor breast cancer prognosis. Selenoprotein expression stringently depends on selenium availability, hence circulating selenium may interact with tumour selenoprotein expression. However, there is no matched analysis to date.
Methods
This study included 1453 patients with newly diagnosed breast cancer from the multicentric prospective Sweden Cancerome Analysis Network – Breast study. Total serum selenium, selenoprotein P and glutathione peroxidase 3 were analysed at time of diagnosis. Bulk RNA-sequencing was conducted in matched tumour tissues. Fully adjusted Cox regression models with an interaction term were... (More)
Introduction
Low serum selenium and altered tumour RNA expression of certain selenoproteins are associated with a poor breast cancer prognosis. Selenoprotein expression stringently depends on selenium availability, hence circulating selenium may interact with tumour selenoprotein expression. However, there is no matched analysis to date.
Methods
This study included 1453 patients with newly diagnosed breast cancer from the multicentric prospective Sweden Cancerome Analysis Network – Breast study. Total serum selenium, selenoprotein P and glutathione peroxidase 3 were analysed at time of diagnosis. Bulk RNA-sequencing was conducted in matched tumour tissues. Fully adjusted Cox regression models with an interaction term were employed to detect dose-dependent interactions of circulating selenium with the associations of tumour selenoprotein mRNA expression and mortality.
Results
237 deaths were recorded within ~ 9 years follow-up. All three serum selenium biomarkers correlated positively (p Conclusions
This first unbiased analysis of serum selenium with the breast cancer selenotranscriptome identified an effect-modification of selenium on the associations of DIO1, SELENOM, and DIO3 with prognosis. Selenium substitution in patients with DIO1-expressing tumours merits consideration to improve survival. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Translational Medicine
article number
658
publisher
BioMed Central (BMC)
external identifiers
  • scopus:85172372078
  • pmid:37741974
ISSN
1479-5876
DOI
10.1186/s12967-023-04502-y
project
Sweden Cancerome Analysis Network - Breast (SCAN-B): a large-scale multicenter infrastructure towards implementation of breast cancer genomic analyses in the clinical routine
language
English
LU publication?
yes
id
cc3cf504-6a38-4a10-8d1e-3a48fa241e84
date added to LUP
2023-09-23 13:39:13
date last changed
2023-12-24 03:00:02
@article{cc3cf504-6a38-4a10-8d1e-3a48fa241e84,
  abstract     = {{Introduction<br/>Low serum selenium and altered tumour RNA expression of certain selenoproteins are associated with a poor breast cancer prognosis. Selenoprotein expression stringently depends on selenium availability, hence circulating selenium may interact with tumour selenoprotein expression. However, there is no matched analysis to date.<br/>Methods<br/>This study included 1453 patients with newly diagnosed breast cancer from the multicentric prospective Sweden Cancerome Analysis Network – Breast study. Total serum selenium, selenoprotein P and glutathione peroxidase 3 were analysed at time of diagnosis. Bulk RNA-sequencing was conducted in matched tumour tissues. Fully adjusted Cox regression models with an interaction term were employed to detect dose-dependent interactions of circulating selenium with the associations of tumour selenoprotein mRNA expression and mortality.<br/>Results<br/>237 deaths were recorded within ~ 9 years follow-up. All three serum selenium biomarkers correlated positively (p Conclusions<br/>This first unbiased analysis of serum selenium with the breast cancer selenotranscriptome identified an effect-modification of selenium on the associations of DIO1, SELENOM, and DIO3 with prognosis. Selenium substitution in patients with DIO1-expressing tumours merits consideration to improve survival.}},
  author       = {{Demircan, Kamil and Bengtsson, Ylva and Samson Chillon, Thilo and Vallon-Christersson, Johan and Sun, Qian and Larsson, Christer and Malmberg, Martin and Saal, Lao and Ryden, Lisa and Borg, Åke and Manjer, Jonas and Schomburg, Lutz}},
  issn         = {{1479-5876}},
  language     = {{eng}},
  month        = {{09}},
  publisher    = {{BioMed Central (BMC)}},
  series       = {{Journal of Translational Medicine}},
  title        = {{Matched analysis of circulating selenium with the breast cancer selenotranscriptome: a multicentre prospective study}},
  url          = {{http://dx.doi.org/10.1186/s12967-023-04502-y}},
  doi          = {{10.1186/s12967-023-04502-y}},
  year         = {{2023}},
}