Seasonal variation of vasopressin and its relevance for the winter peak of cardiometabolic disease : A pooled analysis of five cohorts
(2022) In Journal of Internal Medicine 292(2). p.365-376- Abstract
Background: Vasopressin concentration is typically higher at night, during stress, and in males, but readily lowered by water intake. Vasopressin is also a causal candidate for cardiometabolic disease, which shows seasonal variation. Objective: To study whether vasopressin concentration varies by season in a temperate climate. Methods: The vasopressin surrogate marker copeptin was analyzed in fasting plasma samples from five population-based cohorts in Malmö, Sweden (n = 25,907, 50.4% women, age 18–86 years). We investigated seasonal variation of copeptin concentration and adjusted for confounders in sinusoidal models. Results: The predicted median copeptin level was 5.81 pmol/L (7.18 pmol/L for men and 4.44 pmol/L for women). Copeptin... (More)
Background: Vasopressin concentration is typically higher at night, during stress, and in males, but readily lowered by water intake. Vasopressin is also a causal candidate for cardiometabolic disease, which shows seasonal variation. Objective: To study whether vasopressin concentration varies by season in a temperate climate. Methods: The vasopressin surrogate marker copeptin was analyzed in fasting plasma samples from five population-based cohorts in Malmö, Sweden (n = 25,907, 50.4% women, age 18–86 years). We investigated seasonal variation of copeptin concentration and adjusted for confounders in sinusoidal models. Results: The predicted median copeptin level was 5.81 pmol/L (7.18 pmol/L for men and 4.44 pmol/L for women). Copeptin exhibited a distinct seasonal pattern with a peak in winter (mid-February to mid-March) and nadir in late summer (mid-August to mid-September). The adjusted absolute seasonal variation in median copeptin was 0.62 pmol/L (95% confidence interval [CI] 0.50; 0.74, 0.98 pmol/L [95% CI 0.73; 1.23] for men and 0.46 pmol/L [95% CI 0.33; 0.59] for women). The adjusted relative seasonal variation in mean log copeptin z-score was 0.20 (95% CI 0.17; 0.24, 0.18 [95% CI 0.14; 0.23] in men and 0.24 [95% CI 0.19; 0.29] in women). The observed seasonal variation of copeptin corresponded to a risk increase of 4% for incident diabetes mellitus and 2% for incident coronary artery disease. Conclusion: The seasonal variation of the vasopressin marker copeptin corresponds to increased disease risk and mirrors the known variation in cardiometabolic status across the year. Moderately increased water intake might mitigate the winter peak of cardiometabolic disease.
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- author
- Enhörning, Sofia LU ; Melander, Olle LU ; Engström, Gunnar LU ; Elmståhl, Sölve LU ; Lind, Lars ; Nilsson, Peter M. LU ; Pihlsgård, Mats LU and Timpka, Simon LU
- organization
-
- Perinatal and cardiovascular epidemiology (research group)
- EXODIAB: Excellence of Diabetes Research in Sweden
- MultiPark: Multidisciplinary research focused on Parkinson´s disease
- EpiHealth: Epidemiology for Health
- Cardiovascular Research - Hypertension (research group)
- Cardiovascular Research - Epidemiology (research group)
- Geriatrics (research group)
- Internal Medicine - Epidemiology (research group)
- publishing date
- 2022
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- body mass index, copeptin, coronary artery disease, diabetes mellitus, seasonality
- in
- Journal of Internal Medicine
- volume
- 292
- issue
- 2
- pages
- 365 - 376
- publisher
- Wiley-Blackwell
- external identifiers
-
- scopus:85128208541
- pmid:35340071
- ISSN
- 0954-6820
- DOI
- 10.1111/joim.13489
- language
- English
- LU publication?
- yes
- id
- cd9b8946-dd03-4772-8a34-c7a12331c8a4
- date added to LUP
- 2022-07-05 14:09:18
- date last changed
- 2024-09-18 05:16:01
@article{cd9b8946-dd03-4772-8a34-c7a12331c8a4, abstract = {{<p>Background: Vasopressin concentration is typically higher at night, during stress, and in males, but readily lowered by water intake. Vasopressin is also a causal candidate for cardiometabolic disease, which shows seasonal variation. Objective: To study whether vasopressin concentration varies by season in a temperate climate. Methods: The vasopressin surrogate marker copeptin was analyzed in fasting plasma samples from five population-based cohorts in Malmö, Sweden (n = 25,907, 50.4% women, age 18–86 years). We investigated seasonal variation of copeptin concentration and adjusted for confounders in sinusoidal models. Results: The predicted median copeptin level was 5.81 pmol/L (7.18 pmol/L for men and 4.44 pmol/L for women). Copeptin exhibited a distinct seasonal pattern with a peak in winter (mid-February to mid-March) and nadir in late summer (mid-August to mid-September). The adjusted absolute seasonal variation in median copeptin was 0.62 pmol/L (95% confidence interval [CI] 0.50; 0.74, 0.98 pmol/L [95% CI 0.73; 1.23] for men and 0.46 pmol/L [95% CI 0.33; 0.59] for women). The adjusted relative seasonal variation in mean log copeptin z-score was 0.20 (95% CI 0.17; 0.24, 0.18 [95% CI 0.14; 0.23] in men and 0.24 [95% CI 0.19; 0.29] in women). The observed seasonal variation of copeptin corresponded to a risk increase of 4% for incident diabetes mellitus and 2% for incident coronary artery disease. Conclusion: The seasonal variation of the vasopressin marker copeptin corresponds to increased disease risk and mirrors the known variation in cardiometabolic status across the year. Moderately increased water intake might mitigate the winter peak of cardiometabolic disease.</p>}}, author = {{Enhörning, Sofia and Melander, Olle and Engström, Gunnar and Elmståhl, Sölve and Lind, Lars and Nilsson, Peter M. and Pihlsgård, Mats and Timpka, Simon}}, issn = {{0954-6820}}, keywords = {{body mass index; copeptin; coronary artery disease; diabetes mellitus; seasonality}}, language = {{eng}}, number = {{2}}, pages = {{365--376}}, publisher = {{Wiley-Blackwell}}, series = {{Journal of Internal Medicine}}, title = {{Seasonal variation of vasopressin and its relevance for the winter peak of cardiometabolic disease : A pooled analysis of five cohorts}}, url = {{http://dx.doi.org/10.1111/joim.13489}}, doi = {{10.1111/joim.13489}}, volume = {{292}}, year = {{2022}}, }