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RUBIC (ReproUnion Biobank and Infertility Cohort) : A binational clinical foundation to study risk factors, life course, and treatment of infertility and infertility-related morbidity

Priskorn, Lærke ; Tøttenborg, Sandra Søgaard ; Almstrup, Kristian ; Andersson, Anna Maria ; Axelsson, Jonatan ; Bräuner, Elvira Vaclavik ; Elenkov, Angel LU ; Freiesleben, Nina la Cour ; Giwercman, Yvonne Lundberg LU and Grøndahl, Marie Louise , et al. (2021) In Andrology 9(6). p.1828-1842
Abstract

Background: Infertility affects 15%–25% of all couples during their reproductive life span. It is a significant societal and public health problem with potential psychological, social, and economic consequences. Furthermore, infertility has been linked to adverse long-term health outcomes. Despite the advanced diagnostic and therapeutic techniques available, approximately 30% of infertile couples do not obtain a live birth after fertility treatment. For these couples, there are no further options to increase their chances of a successful pregnancy and live birth. Objectives: Three overall questions will be studied: (1) What are the risk factors and natural life courses of infertility, early embryonic loss, and adverse pregnancy... (More)

Background: Infertility affects 15%–25% of all couples during their reproductive life span. It is a significant societal and public health problem with potential psychological, social, and economic consequences. Furthermore, infertility has been linked to adverse long-term health outcomes. Despite the advanced diagnostic and therapeutic techniques available, approximately 30% of infertile couples do not obtain a live birth after fertility treatment. For these couples, there are no further options to increase their chances of a successful pregnancy and live birth. Objectives: Three overall questions will be studied: (1) What are the risk factors and natural life courses of infertility, early embryonic loss, and adverse pregnancy outcomes? (2) Can we develop new diagnostic and prognostic biomarkers for fecundity and treatment success? And (3) what are the health characteristics of women and men in infertile couples at the time of fertility treatment and during long-term follow-up?. Material and Methods: ReproUnion Biobank and Infertility Cohort (RUBIC) is established as an add-on to the routine fertility management at Copenhagen University Hospital Departments in the Capital Region of Denmark and Reproductive Medicine Centre at Skåne University Hospital in Sweden. The aim is to include a total of 5000 couples equally distributed between Denmark and Sweden. The first patients were enrolled in June 2020. All eligible infertile couples are prospectively asked to participate in the project. Participants complete an extensive questionnaire and undergo a physical examination and collection of biospecimens (blood, urine, hair, saliva, rectal swabs, feces, semen, endometrial biopsies, and vaginal swabs). After the cohort is established, the couples will be linked to the Danish and Swedish national registers to obtain information on parental, perinatal, childhood, and adult life histories, including disease and medication history. This will enable us to understand the causes of infertility and identify novel therapeutic options for this important societal problem.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
epigenetics, human microbiome/microbiota, infertility, medically assisted reproduction, reproductive disorders, semen quality
in
Andrology
volume
9
issue
6
pages
1828 - 1842
publisher
Wiley-Blackwell
external identifiers
  • scopus:85108217849
  • pmid:34114375
ISSN
2047-2919
DOI
10.1111/andr.13063
language
English
LU publication?
yes
id
cecebc91-262a-4337-836e-2c8733faee9f
date added to LUP
2021-07-13 13:48:24
date last changed
2024-06-15 13:24:48
@article{cecebc91-262a-4337-836e-2c8733faee9f,
  abstract     = {{<p>Background: Infertility affects 15%–25% of all couples during their reproductive life span. It is a significant societal and public health problem with potential psychological, social, and economic consequences. Furthermore, infertility has been linked to adverse long-term health outcomes. Despite the advanced diagnostic and therapeutic techniques available, approximately 30% of infertile couples do not obtain a live birth after fertility treatment. For these couples, there are no further options to increase their chances of a successful pregnancy and live birth. Objectives: Three overall questions will be studied: (1) What are the risk factors and natural life courses of infertility, early embryonic loss, and adverse pregnancy outcomes? (2) Can we develop new diagnostic and prognostic biomarkers for fecundity and treatment success? And (3) what are the health characteristics of women and men in infertile couples at the time of fertility treatment and during long-term follow-up?. Material and Methods: ReproUnion Biobank and Infertility Cohort (RUBIC) is established as an add-on to the routine fertility management at Copenhagen University Hospital Departments in the Capital Region of Denmark and Reproductive Medicine Centre at Skåne University Hospital in Sweden. The aim is to include a total of 5000 couples equally distributed between Denmark and Sweden. The first patients were enrolled in June 2020. All eligible infertile couples are prospectively asked to participate in the project. Participants complete an extensive questionnaire and undergo a physical examination and collection of biospecimens (blood, urine, hair, saliva, rectal swabs, feces, semen, endometrial biopsies, and vaginal swabs). After the cohort is established, the couples will be linked to the Danish and Swedish national registers to obtain information on parental, perinatal, childhood, and adult life histories, including disease and medication history. This will enable us to understand the causes of infertility and identify novel therapeutic options for this important societal problem.</p>}},
  author       = {{Priskorn, Lærke and Tøttenborg, Sandra Søgaard and Almstrup, Kristian and Andersson, Anna Maria and Axelsson, Jonatan and Bräuner, Elvira Vaclavik and Elenkov, Angel and Freiesleben, Nina la Cour and Giwercman, Yvonne Lundberg and Grøndahl, Marie Louise and Hansen, Ann Holm and Hansen, Laura Smidt and Henic, Emir and Kitlinski, Margareta Laczna and Landersoe, Selma Kloeve and Lindh, Christian and Løkkegaard, Ellen Leth and Malm, Johan and Olsen, Kristina Wendelboe and Petersen, Kajsa Uglevig and Schmidt, Lone and Stormlund, Sacha and Svendsen, Pernille Fog and Vassard, Ditte and Wang, Nathalie Friis and Zedeler, Anne and Bhasin, Shalender and Chavarro, Jorge and Eisenberg, Michael L. and Hauser, Russ and Huhtaniemi, Ilpo and Krawetz, Stephen A. and Marko-Varga, György and Salonia, Andrea and Toppari, Jorma and Juul, Anders and Jørgensen, Niels and Nielsen, Henriette Svarre and Pinborg, Anja and Rylander, Lars and Giwercman, Aleksander}},
  issn         = {{2047-2919}},
  keywords     = {{epigenetics; human microbiome/microbiota; infertility; medically assisted reproduction; reproductive disorders; semen quality}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{1828--1842}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Andrology}},
  title        = {{RUBIC (ReproUnion Biobank and Infertility Cohort) : A binational clinical foundation to study risk factors, life course, and treatment of infertility and infertility-related morbidity}},
  url          = {{http://dx.doi.org/10.1111/andr.13063}},
  doi          = {{10.1111/andr.13063}},
  volume       = {{9}},
  year         = {{2021}},
}