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Cyclin A1 expression and associations with disease characteristics in childhood acute lymphoblastic leukemia.

Wigerup, Caroline LU ; Øra, Ingrid LU ; Brunhoff, Cecilia LU ; Anagnostaki, Lola; Landberg, Göran LU and Persson, Jenny L LU (2006) In Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis 30(3). p.254-261
Abstract
A critical cell cycle regulatory protein, cyclin A1, has been implicated in the development of acute myeloid leukemia (AML). Here, we have examined the expression and clinical significance of cyclin A1 in childhood acute lymphoblastic leukemia (ALL). Cyclin A1 was highly expressed in lymphoblastic leukemic cell lines and in 22 of 30 ALL patients (73%). Cyclin A1 expression correlated with patient age (P=0.006), but not with cytogenetic abnormalities. Patients with high levels of cyclin A1 had poorer event-free survival (57.9%) compared to patients with lower levels (75%). (c) 2005 Elsevier Ltd. All rights reserved.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cyclin A1, cyclin dependent kinase, event, acute lymphoblastic leukemia, free survival, cell cycle, disease characteristics
in
Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis
volume
30
issue
3
pages
254 - 261
publisher
Elsevier
external identifiers
  • pmid:16182364
  • wos:000235039900002
  • scopus:30144443209
ISSN
1873-5835
DOI
10.1016/j.leukres.2005.07.010
language
English
LU publication?
yes
id
d111a3d6-741e-43b4-a3a8-90921470271e (old id 143450)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16182364&dopt=Abstract
date added to LUP
2007-07-25 11:53:33
date last changed
2019-08-14 01:38:19
@article{d111a3d6-741e-43b4-a3a8-90921470271e,
  abstract     = {A critical cell cycle regulatory protein, cyclin A1, has been implicated in the development of acute myeloid leukemia (AML). Here, we have examined the expression and clinical significance of cyclin A1 in childhood acute lymphoblastic leukemia (ALL). Cyclin A1 was highly expressed in lymphoblastic leukemic cell lines and in 22 of 30 ALL patients (73%). Cyclin A1 expression correlated with patient age (P=0.006), but not with cytogenetic abnormalities. Patients with high levels of cyclin A1 had poorer event-free survival (57.9%) compared to patients with lower levels (75%). (c) 2005 Elsevier Ltd. All rights reserved.},
  author       = {Wigerup, Caroline and Øra, Ingrid and Brunhoff, Cecilia and Anagnostaki, Lola and Landberg, Göran and Persson, Jenny L},
  issn         = {1873-5835},
  keyword      = {cyclin A1,cyclin dependent kinase,event,acute lymphoblastic leukemia,free survival,cell cycle,disease characteristics},
  language     = {eng},
  number       = {3},
  pages        = {254--261},
  publisher    = {Elsevier},
  series       = {Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis},
  title        = {Cyclin A1 expression and associations with disease characteristics in childhood acute lymphoblastic leukemia.},
  url          = {http://dx.doi.org/10.1016/j.leukres.2005.07.010},
  volume       = {30},
  year         = {2006},
}