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Identification of cardiac afterload dynamics from data

Pigot, Harry LU orcid ; Hansson, Jonas LU orcid ; Paskevicius, Audrius LU ; Liao, Qiuming LU ; Sjöberg, Trygve LU ; Steen, Stig LU and Soltesz, Kristian LU orcid (2021) 11th IFAC Symposium on Biological and Medical Systems In IFAC-PapersOnLine 54. p.508-513
Abstract
The prospect of ex vivo functional evaluation of donor hearts is considered. Particularly, the dynamics of a synthetic cardiac afterload model are compared to those of normal physiology. A method for identification of continuous-time transfer functions from sampled data is developed and verified against results from the literature. The method relies on exact gradients and Hessians obtained through automatic differentiation. This also enables straightforward sensitivity analyses. Such analyses reveal that the 4-element Windkessel model is not practically identifiable from representative data while the 3-element model underfits the data. Pressure–volume (PV) loops are therefore suggested as an alternative for comparing afterload dynamics.
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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
IFAC-PapersOnLine
volume
54
pages
508 - 513
publisher
IFAC Secretariat
conference name
11th IFAC Symposium on Biological and Medical Systems
conference location
Ghent, Belgium
conference dates
2021-09-19 - 2021-09-22
external identifiers
  • scopus:85120684414
ISSN
2405-8963
DOI
10.1016/j.ifacol.2021.10.307
project
Functional ex vivo heart evaluation
Hemodynamic Stabilization
language
English
LU publication?
yes
id
d1f295bb-9a17-49a3-b2bb-495789022830
date added to LUP
2021-11-03 14:52:00
date last changed
2024-05-18 18:25:43
@article{d1f295bb-9a17-49a3-b2bb-495789022830,
  abstract     = {{The prospect of ex vivo functional evaluation of donor hearts is considered. Particularly, the dynamics of a synthetic cardiac afterload model are compared to those of normal physiology. A method for identification of continuous-time transfer functions from sampled data is developed and verified against results from the literature. The method relies on exact gradients and Hessians obtained through automatic differentiation. This also enables straightforward sensitivity analyses. Such analyses reveal that the 4-element Windkessel model is not practically identifiable from representative data while the 3-element model underfits the data. Pressure–volume (PV) loops are therefore suggested as an alternative for comparing afterload dynamics.}},
  author       = {{Pigot, Harry and Hansson, Jonas and Paskevicius, Audrius and Liao, Qiuming and Sjöberg, Trygve and Steen, Stig and Soltesz, Kristian}},
  issn         = {{2405-8963}},
  language     = {{eng}},
  pages        = {{508--513}},
  publisher    = {{IFAC Secretariat}},
  series       = {{IFAC-PapersOnLine}},
  title        = {{Identification of cardiac afterload dynamics from data}},
  url          = {{https://lup.lub.lu.se/search/files/109257090/soltesz21c.pdf}},
  doi          = {{10.1016/j.ifacol.2021.10.307}},
  volume       = {{54}},
  year         = {{2021}},
}