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The effects of delayed nerve repair on nerve regeneration in a silicone chamber model

Danielsen, Nils LU ; Johansson, B R LU and Dahlin, L B LU (1994) In Restorative Neurology and Neuroscience 6(4). p.317-322
Abstract

The silicone chamber model for nerve regeneration is suitable to test the effects of exogenous agents or surgical manipulations on nerve regeneration. The total 16-day regeneration period used in this model makes it possible to analyze the effects of certain manipulations on the sequential advancement of the individual cellular components (circumferential perineurial-like cells, vessels, Schwann cells, axons, and myelin) into the chamber fibrin matrix. In the present study we compared the effects on cellular migration of a 7 day delayed chamber repair vs. chamber repair immediately after transection (control chambers) of the rat sciatic nerve. Regeneration was evaluated with light and electron microscopic techniques. Chambers implanted... (More)

The silicone chamber model for nerve regeneration is suitable to test the effects of exogenous agents or surgical manipulations on nerve regeneration. The total 16-day regeneration period used in this model makes it possible to analyze the effects of certain manipulations on the sequential advancement of the individual cellular components (circumferential perineurial-like cells, vessels, Schwann cells, axons, and myelin) into the chamber fibrin matrix. In the present study we compared the effects on cellular migration of a 7 day delayed chamber repair vs. chamber repair immediately after transection (control chambers) of the rat sciatic nerve. Regeneration was evaluated with light and electron microscopic techniques. Chambers implanted after a delay of 7 days had a statistically significant more advanced migration of vessels, Schwann cells, and axons from the proximal nerve stump and also a significantly increased vascular density as compared to control chambers. We conclude that a 7 day delayed nerve repair stimulates nerve regeneration in this specific silicone chamber model.

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author
organization
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Contribution to journal
publication status
published
subject
keywords
Journal Article
in
Restorative Neurology and Neuroscience
volume
6
issue
4
pages
6 pages
publisher
IOS Press
external identifiers
  • scopus:0028233890
ISSN
0922-6028
DOI
10.3233/RNN-1994-6408
language
English
LU publication?
yes
id
d229b5f8-2a23-4c4e-a7c9-39434acec48e
date added to LUP
2017-10-13 14:05:18
date last changed
2017-11-29 12:29:31
@article{d229b5f8-2a23-4c4e-a7c9-39434acec48e,
  abstract     = {<p>The silicone chamber model for nerve regeneration is suitable to test the effects of exogenous agents or surgical manipulations on nerve regeneration. The total 16-day regeneration period used in this model makes it possible to analyze the effects of certain manipulations on the sequential advancement of the individual cellular components (circumferential perineurial-like cells, vessels, Schwann cells, axons, and myelin) into the chamber fibrin matrix. In the present study we compared the effects on cellular migration of a 7 day delayed chamber repair vs. chamber repair immediately after transection (control chambers) of the rat sciatic nerve. Regeneration was evaluated with light and electron microscopic techniques. Chambers implanted after a delay of 7 days had a statistically significant more advanced migration of vessels, Schwann cells, and axons from the proximal nerve stump and also a significantly increased vascular density as compared to control chambers. We conclude that a 7 day delayed nerve repair stimulates nerve regeneration in this specific silicone chamber model.</p>},
  author       = {Danielsen, Nils and Johansson, B R and Dahlin, L B},
  issn         = {0922-6028},
  keyword      = {Journal Article},
  language     = {eng},
  month        = {01},
  number       = {4},
  pages        = {317--322},
  publisher    = {IOS Press},
  series       = {Restorative Neurology and Neuroscience},
  title        = {The effects of delayed nerve repair on nerve regeneration in a silicone chamber model},
  url          = {http://dx.doi.org/10.3233/RNN-1994-6408},
  volume       = {6},
  year         = {1994},
}