The effects of delayed nerve repair on nerve regeneration in a silicone chamber model
Danielsen, Nils LU ; Johansson, B R LU and Dahlin, L B LU
(1994)
In Restorative Neurology and Neuroscience
6(4).
p.317-322
- Abstract
The silicone chamber model for nerve regeneration is suitable to test the effects of exogenous agents or surgical manipulations on nerve regeneration. The total 16-day regeneration period used in this model makes it possible to analyze the effects of certain manipulations on the sequential advancement of the individual cellular components (circumferential perineurial-like cells, vessels, Schwann cells, axons, and myelin) into the chamber fibrin matrix. In the present study we compared the effects on cellular migration of a 7 day delayed chamber repair vs. chamber repair immediately after transection (control chambers) of the rat sciatic nerve. Regeneration was evaluated with light and electron microscopic techniques. Chambers implanted... (More)
The silicone chamber model for nerve regeneration is suitable to test the effects of exogenous agents or surgical manipulations on nerve regeneration. The total 16-day regeneration period used in this model makes it possible to analyze the effects of certain manipulations on the sequential advancement of the individual cellular components (circumferential perineurial-like cells, vessels, Schwann cells, axons, and myelin) into the chamber fibrin matrix. In the present study we compared the effects on cellular migration of a 7 day delayed chamber repair vs. chamber repair immediately after transection (control chambers) of the rat sciatic nerve. Regeneration was evaluated with light and electron microscopic techniques. Chambers implanted after a delay of 7 days had a statistically significant more advanced migration of vessels, Schwann cells, and axons from the proximal nerve stump and also a significantly increased vascular density as compared to control chambers. We conclude that a 7 day delayed nerve repair stimulates nerve regeneration in this specific silicone chamber model.
(Less)
- author
- Danielsen, Nils
LU
; Johansson, B R
LU
and Dahlin, L B
LU
- organization
- publishing date
- 1994-01-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Journal Article
- in
- Restorative Neurology and Neuroscience
- volume
- 6
- issue
- 4
- pages
- 6 pages
- publisher
- IOS Press
- external identifiers
-
- scopus:0028233890
- pmid:21551763
- ISSN
- 0922-6028
- DOI
- 10.3233/RNN-1994-6408
- language
- English
- LU publication?
- yes
- id
- d229b5f8-2a23-4c4e-a7c9-39434acec48e
- date added to LUP
- 2017-10-13 14:05:18
- date last changed
- 2024-01-14 07:25:06
@article{d229b5f8-2a23-4c4e-a7c9-39434acec48e,
abstract = {{<p>The silicone chamber model for nerve regeneration is suitable to test the effects of exogenous agents or surgical manipulations on nerve regeneration. The total 16-day regeneration period used in this model makes it possible to analyze the effects of certain manipulations on the sequential advancement of the individual cellular components (circumferential perineurial-like cells, vessels, Schwann cells, axons, and myelin) into the chamber fibrin matrix. In the present study we compared the effects on cellular migration of a 7 day delayed chamber repair vs. chamber repair immediately after transection (control chambers) of the rat sciatic nerve. Regeneration was evaluated with light and electron microscopic techniques. Chambers implanted after a delay of 7 days had a statistically significant more advanced migration of vessels, Schwann cells, and axons from the proximal nerve stump and also a significantly increased vascular density as compared to control chambers. We conclude that a 7 day delayed nerve repair stimulates nerve regeneration in this specific silicone chamber model.</p>}},
author = {{Danielsen, Nils and Johansson, B R and Dahlin, L B}},
issn = {{0922-6028}},
keywords = {{Journal Article}},
language = {{eng}},
month = {{01}},
number = {{4}},
pages = {{317--322}},
publisher = {{IOS Press}},
series = {{Restorative Neurology and Neuroscience}},
title = {{The effects of delayed nerve repair on nerve regeneration in a silicone chamber model}},
url = {{http://dx.doi.org/10.3233/RNN-1994-6408}},
doi = {{10.3233/RNN-1994-6408}},
volume = {{6}},
year = {{1994}},
}