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Neurocognitive and cerebellar function in ADHD, autism and spinocerebellar ataxia

Cundari, Maurizio LU ; Vestberg, Susanna LU ; Gustafsson, Peik LU orcid ; Gorcenco, Sorina LU orcid and Rasmussen, Anders LU orcid (2023) In Frontiers in Systems Neuroscience 17. p.1-20
Abstract

The cerebellum plays a major role in balance, motor control and sensorimotor integration, but also in cognition, language, and emotional regulation. Several neuropsychiatric disorders such as attention deficit-hyperactivity disorder (ADHD), autism spectrum disorder (ASD), as well as neurological diseases such as spinocerebellar ataxia type 3 (SCA3) are associated with differences in cerebellar function. Morphological abnormalities in different cerebellar subregions produce distinct behavioral symptoms related to the functional disruption of specific cerebro-cerebellar circuits. The specific contribution of the cerebellum to typical development may therefore involve the optimization of the structure and function of cerebro-cerebellar... (More)

The cerebellum plays a major role in balance, motor control and sensorimotor integration, but also in cognition, language, and emotional regulation. Several neuropsychiatric disorders such as attention deficit-hyperactivity disorder (ADHD), autism spectrum disorder (ASD), as well as neurological diseases such as spinocerebellar ataxia type 3 (SCA3) are associated with differences in cerebellar function. Morphological abnormalities in different cerebellar subregions produce distinct behavioral symptoms related to the functional disruption of specific cerebro-cerebellar circuits. The specific contribution of the cerebellum to typical development may therefore involve the optimization of the structure and function of cerebro-cerebellar circuits underlying skill acquisition in multiple domains. Here, we review cerebellar structural and functional differences between healthy and patients with ADHD, ASD, and SCA3, and explore how disruption of cerebellar networks affects the neurocognitive functions in these conditions. We discuss how cerebellar computations contribute to performance on cognitive and motor tasks and how cerebellar signals are interfaced with signals from other brain regions during normal and dysfunctional behavior. We conclude that the cerebellum plays a role in many cognitive functions. Still, more clinical studies with the support of neuroimaging are needed to clarify the cerebellum's role in normal and dysfunctional behavior and cognitive functioning.

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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Frontiers in Systems Neuroscience
volume
17
article number
1168666
pages
1 - 20
publisher
Frontiers Media S. A.
external identifiers
  • pmid:37415926
  • scopus:85164513567
ISSN
1662-5137
DOI
10.3389/fnsys.2023.1168666
language
English
LU publication?
yes
additional info
Copyright © 2023 Cundari, Vestberg, Gustafsson, Gorcenco and Rasmussen.
id
d26fee18-27db-4bdc-a104-17207d213286
date added to LUP
2023-07-09 14:33:56
date last changed
2024-11-02 19:01:47
@article{d26fee18-27db-4bdc-a104-17207d213286,
  abstract     = {{<p>The cerebellum plays a major role in balance, motor control and sensorimotor integration, but also in cognition, language, and emotional regulation. Several neuropsychiatric disorders such as attention deficit-hyperactivity disorder (ADHD), autism spectrum disorder (ASD), as well as neurological diseases such as spinocerebellar ataxia type 3 (SCA3) are associated with differences in cerebellar function. Morphological abnormalities in different cerebellar subregions produce distinct behavioral symptoms related to the functional disruption of specific cerebro-cerebellar circuits. The specific contribution of the cerebellum to typical development may therefore involve the optimization of the structure and function of cerebro-cerebellar circuits underlying skill acquisition in multiple domains. Here, we review cerebellar structural and functional differences between healthy and patients with ADHD, ASD, and SCA3, and explore how disruption of cerebellar networks affects the neurocognitive functions in these conditions. We discuss how cerebellar computations contribute to performance on cognitive and motor tasks and how cerebellar signals are interfaced with signals from other brain regions during normal and dysfunctional behavior. We conclude that the cerebellum plays a role in many cognitive functions. Still, more clinical studies with the support of neuroimaging are needed to clarify the cerebellum's role in normal and dysfunctional behavior and cognitive functioning.</p>}},
  author       = {{Cundari, Maurizio and Vestberg, Susanna and Gustafsson, Peik and Gorcenco, Sorina and Rasmussen, Anders}},
  issn         = {{1662-5137}},
  language     = {{eng}},
  pages        = {{1--20}},
  publisher    = {{Frontiers Media S. A.}},
  series       = {{Frontiers in Systems Neuroscience}},
  title        = {{Neurocognitive and cerebellar function in ADHD, autism and spinocerebellar ataxia}},
  url          = {{http://dx.doi.org/10.3389/fnsys.2023.1168666}},
  doi          = {{10.3389/fnsys.2023.1168666}},
  volume       = {{17}},
  year         = {{2023}},
}