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Neurobehavioral symptoms in children born extremely preterm : A Swedish National Study

Serenius, Fredrik ; Kaul, Ylva Fredriksson ; Källén, Karin LU ; Hafström, Maria ; Ådén, Ulrika ; Stjernqvist, Karin and Farooqi, Aijaz (2023) In Acta Paediatrica, International Journal of Paediatrics 112(11). p.2387-2399
Abstract

Aim: To determine the prevalence of neurobehavioral symptoms at 6.5 years in children born extremely preterm (EPT, <27 weeks' gestation). Methods: Population-based cohort study of infants born EPT in Sweden from 2004 to 2007. Of 486 survivors 375 were assessed and compared with 369 matched term-born controls. EPT children free from neurosensory and intellectual disabilities (neurodevelopmental disabilities [NDD]-free, n = 236) were compared separately. Standardised questionnaires were used to assess parental ratings of hyperactivity and attention, emotional, peer-relation, conduct and social problems; and deficits in perception, language and memory. Results: EPT children had more reported problems in all assessed neurobehavioral... (More)

Aim: To determine the prevalence of neurobehavioral symptoms at 6.5 years in children born extremely preterm (EPT, <27 weeks' gestation). Methods: Population-based cohort study of infants born EPT in Sweden from 2004 to 2007. Of 486 survivors 375 were assessed and compared with 369 matched term-born controls. EPT children free from neurosensory and intellectual disabilities (neurodevelopmental disabilities [NDD]-free, n = 236) were compared separately. Standardised questionnaires were used to assess parental ratings of hyperactivity and attention, emotional, peer-relation, conduct and social problems; and deficits in perception, language and memory. Results: EPT children had more reported problems in all assessed neurobehavioral domains than controls, with more than three times greater odds for most outcomes. Except for conduct problems, increased problems were identified also in NDD–free children. The odds of having neurobehavioral problems in ≥3 co-occurring domains were five (whole EPT group) and three (NDD-free group) times higher than in controls. Conclusion: EPT children with or without NDD have more neurobehavioral problems in multiple domains than term peers. Ongoing assessments of behaviour until school age or beyond should recognise early symptoms of attention, everyday social problems, perceptual, emotional or language difficulties.

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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cohort study, development, language, mental health, perception
in
Acta Paediatrica, International Journal of Paediatrics
volume
112
issue
11
pages
13 pages
publisher
Wiley-Blackwell
external identifiers
  • scopus:85168918130
  • pmid:37551108
ISSN
0803-5253
DOI
10.1111/apa.16942
language
English
LU publication?
yes
id
d2df4b5c-5272-493c-9592-e0e46c7e8d16
date added to LUP
2023-11-10 14:31:34
date last changed
2024-05-20 09:10:05
@article{d2df4b5c-5272-493c-9592-e0e46c7e8d16,
  abstract     = {{<p>Aim: To determine the prevalence of neurobehavioral symptoms at 6.5 years in children born extremely preterm (EPT, &lt;27 weeks' gestation). Methods: Population-based cohort study of infants born EPT in Sweden from 2004 to 2007. Of 486 survivors 375 were assessed and compared with 369 matched term-born controls. EPT children free from neurosensory and intellectual disabilities (neurodevelopmental disabilities [NDD]-free, n = 236) were compared separately. Standardised questionnaires were used to assess parental ratings of hyperactivity and attention, emotional, peer-relation, conduct and social problems; and deficits in perception, language and memory. Results: EPT children had more reported problems in all assessed neurobehavioral domains than controls, with more than three times greater odds for most outcomes. Except for conduct problems, increased problems were identified also in NDD–free children. The odds of having neurobehavioral problems in ≥3 co-occurring domains were five (whole EPT group) and three (NDD-free group) times higher than in controls. Conclusion: EPT children with or without NDD have more neurobehavioral problems in multiple domains than term peers. Ongoing assessments of behaviour until school age or beyond should recognise early symptoms of attention, everyday social problems, perceptual, emotional or language difficulties.</p>}},
  author       = {{Serenius, Fredrik and Kaul, Ylva Fredriksson and Källén, Karin and Hafström, Maria and Ådén, Ulrika and Stjernqvist, Karin and Farooqi, Aijaz}},
  issn         = {{0803-5253}},
  keywords     = {{cohort study; development; language; mental health; perception}},
  language     = {{eng}},
  number       = {{11}},
  pages        = {{2387--2399}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Acta Paediatrica, International Journal of Paediatrics}},
  title        = {{Neurobehavioral symptoms in children born extremely preterm : A Swedish National Study}},
  url          = {{http://dx.doi.org/10.1111/apa.16942}},
  doi          = {{10.1111/apa.16942}},
  volume       = {{112}},
  year         = {{2023}},
}