Human Atherosclerotic Plaque Progression Is Dependent on Apoptosis According to Bomb-Pulse 14C Dating
Edsfeldt, Andreas LU ; Eriksson Stenström, Kristina LU ; Sun, Jiangming LU
; Dias, Nuno
LU
; Skog, Göran
LU
; Singh, Pratibha
LU
; Mattsson, Sören
LU
; Nilsson, Jan
LU
and Gonçalves, Isabel
LU
(2021)
In JACC: Basic to Translational Science
6(9-10).
p.734-745
- Abstract
- Individuals with rapidly progressing atherosclerotic plaques are at higher risk of experiencing acute complications. Currently, we lack knowledge regarding factors in human plaque that cause rapid progression. Using the 14C bomb-pulse dating method, we assessed the physical age of atherosclerotic plaques and which biological processes were associated with rapidly progressing plaques. Interestingly, increased apoptosis was the main component associated with a young physical plaque age, reflecting rapid plaque progression. Our findings in combination with recent advances in imaging techniques could guide future diagnostic imaging strategies to identify rapidly progressing plaques or therapeutic targets, halting plaque progression.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/d4f33906-cfe0-40cd-832a-d0b01435e030
- author
- Edsfeldt, Andreas
LU
; Eriksson Stenström, Kristina
LU
; Sun, Jiangming
LU
; Dias, Nuno
LU
; Skog, Göran
LU
; Singh, Pratibha
LU
; Mattsson, Sören
LU
; Nilsson, Jan
LU
and Gonçalves, Isabel
LU
- organization
-
- Cardiovascular Research - Translational Studies (research group)
- EXODIAB: Excellence of Diabetes Research in Sweden
- Nuclear physics
- Vascular Diseases - Clinical Research (research group)
- Quaternary Sciences
- Medical Radiation Physics, Malmö (research group)
- Cardiovascular Research - Immunity and Atherosclerosis (research group)
- EpiHealth: Epidemiology for Health
- publishing date
- 2021
- type
- Contribution to journal
- publication status
- published
- subject
- in
- JACC: Basic to Translational Science
- volume
- 6
- issue
- 9-10
- pages
- 734 - 745
- publisher
- Elsevier
- external identifiers
-
- pmid:34754987
- scopus:85122654340
- ISSN
- 2452-302X
- DOI
- 10.1016/j.jacbts.2021.08.005
- language
- English
- LU publication?
- yes
- id
- d4f33906-cfe0-40cd-832a-d0b01435e030
- date added to LUP
- 2022-02-23 09:04:45
- date last changed
- 2023-02-21 11:06:51
@article{d4f33906-cfe0-40cd-832a-d0b01435e030,
abstract = {{Individuals with rapidly progressing atherosclerotic plaques are at higher risk of experiencing acute complications. Currently, we lack knowledge regarding factors in human plaque that cause rapid progression. Using the 14C bomb-pulse dating method, we assessed the physical age of atherosclerotic plaques and which biological processes were associated with rapidly progressing plaques. Interestingly, increased apoptosis was the main component associated with a young physical plaque age, reflecting rapid plaque progression. Our findings in combination with recent advances in imaging techniques could guide future diagnostic imaging strategies to identify rapidly progressing plaques or therapeutic targets, halting plaque progression.}},
author = {{Edsfeldt, Andreas and Eriksson Stenström, Kristina and Sun, Jiangming and Dias, Nuno and Skog, Göran and Singh, Pratibha and Mattsson, Sören and Nilsson, Jan and Gonçalves, Isabel}},
issn = {{2452-302X}},
language = {{eng}},
number = {{9-10}},
pages = {{734--745}},
publisher = {{Elsevier}},
series = {{JACC: Basic to Translational Science}},
title = {{Human Atherosclerotic Plaque Progression Is Dependent on Apoptosis According to Bomb-Pulse 14C Dating}},
url = {{http://dx.doi.org/10.1016/j.jacbts.2021.08.005}},
doi = {{10.1016/j.jacbts.2021.08.005}},
volume = {{6}},
year = {{2021}},
}