Motor associations of iron accumulation in deep grey matter nuclei in Parkinson's disease : A cross-sectional study of iron-related magnetic resonance imaging susceptibility
(2017) In European Journal of Neurology 24(2). p.357-365- Abstract
Background and purpose: To determine whether iron deposition in deep brain nuclei assessed using high-pass filtered phase imaging plays a role in motor disease severity in Parkinson's disease (PD). Methods: Seventy patients with mild to moderate PD and 20 age- and gender-matched healthy volunteers (HVs) underwent susceptibility-weighted imaging on a 3 T magnetic resonance imaging scanner. Phase shifts (radians) in deep brain nuclei were derived from high-pass filtered phase images and compared between groups. Analysis of clinical laterality and correlations with motor severity (Unified Parkinson's Disease Rating Scale, Part III, UPDRS-III) were performed. Phase shifts (in radians) were compared between HVs and three PD subgroups divided... (More)
Background and purpose: To determine whether iron deposition in deep brain nuclei assessed using high-pass filtered phase imaging plays a role in motor disease severity in Parkinson's disease (PD). Methods: Seventy patients with mild to moderate PD and 20 age- and gender-matched healthy volunteers (HVs) underwent susceptibility-weighted imaging on a 3 T magnetic resonance imaging scanner. Phase shifts (radians) in deep brain nuclei were derived from high-pass filtered phase images and compared between groups. Analysis of clinical laterality and correlations with motor severity (Unified Parkinson's Disease Rating Scale, Part III, UPDRS-III) were performed. Phase shifts (in radians) were compared between HVs and three PD subgroups divided according to UPDRS-III scores using analysis of covariance, adjusting for age and regional area. Results: Parkinson's disease patients had significantly (P < 0.001) higher radians than HVs bilaterally in the putamen, globus pallidus and substantia nigra (SN). The SN contralateral to the most affected side showed higher radians (P < 0.001) compared to the less affected side. SN radians positively correlated with UPDRS-III and bradykinesia-rigidity subscores, but not with tremor subscores. ancova followed by post hoc Bonferroni-adjusted pairwise comparisons revealed that SN radians were significantly greater in the PD subgroup with higher UPDRS-III scores compared to both lowest UPDRS-III PD and HV groups (P < 0.001). Conclusions: Increased nigral iron accumulation in PD appears to be stratified according to disease motor severity and correlates with symptoms related to dopaminergic neurodegeneration. This semi-quantitative in vivo iron assessment could prove useful for objectively monitoring PD progression, especially in clinical trials concerning iron chelation therapies.
(Less)
- author
- organization
- publishing date
- 2017
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Iron, Motor severity, Neurodegeneration, Parkinson's disease, SWI
- in
- European Journal of Neurology
- volume
- 24
- issue
- 2
- pages
- 357 - 365
- publisher
- Wiley-Blackwell
- external identifiers
-
- scopus:85006963185
- pmid:27982501
- wos:000392804300023
- ISSN
- 1351-5101
- DOI
- 10.1111/ene.13208
- language
- English
- LU publication?
- yes
- id
- d5064c01-8479-4117-b190-c467d0dff3cf
- date added to LUP
- 2017-01-20 13:51:01
- date last changed
- 2024-04-19 17:17:15
@article{d5064c01-8479-4117-b190-c467d0dff3cf,
abstract = {{<p>Background and purpose: To determine whether iron deposition in deep brain nuclei assessed using high-pass filtered phase imaging plays a role in motor disease severity in Parkinson's disease (PD). Methods: Seventy patients with mild to moderate PD and 20 age- and gender-matched healthy volunteers (HVs) underwent susceptibility-weighted imaging on a 3 T magnetic resonance imaging scanner. Phase shifts (radians) in deep brain nuclei were derived from high-pass filtered phase images and compared between groups. Analysis of clinical laterality and correlations with motor severity (Unified Parkinson's Disease Rating Scale, Part III, UPDRS-III) were performed. Phase shifts (in radians) were compared between HVs and three PD subgroups divided according to UPDRS-III scores using analysis of covariance, adjusting for age and regional area. Results: Parkinson's disease patients had significantly (P < 0.001) higher radians than HVs bilaterally in the putamen, globus pallidus and substantia nigra (SN). The SN contralateral to the most affected side showed higher radians (P < 0.001) compared to the less affected side. SN radians positively correlated with UPDRS-III and bradykinesia-rigidity subscores, but not with tremor subscores. ancova followed by post hoc Bonferroni-adjusted pairwise comparisons revealed that SN radians were significantly greater in the PD subgroup with higher UPDRS-III scores compared to both lowest UPDRS-III PD and HV groups (P < 0.001). Conclusions: Increased nigral iron accumulation in PD appears to be stratified according to disease motor severity and correlates with symptoms related to dopaminergic neurodegeneration. This semi-quantitative in vivo iron assessment could prove useful for objectively monitoring PD progression, especially in clinical trials concerning iron chelation therapies.</p>}},
author = {{Martin-Bastida, A. and Lao-Kaim, N. P. and Loane, C. and Politis, M. and Roussakis, A. A. and Valle-Guzman, N. and Kefalopoulou, Z. and Paul-Visse, G. and Widner, H. and Xing, Y. and Schwarz, S. T. and Auer, D. P. and Foltynie, T. and Barker, R. A. and Piccini, P.}},
issn = {{1351-5101}},
keywords = {{Iron; Motor severity; Neurodegeneration; Parkinson's disease; SWI}},
language = {{eng}},
number = {{2}},
pages = {{357--365}},
publisher = {{Wiley-Blackwell}},
series = {{European Journal of Neurology}},
title = {{Motor associations of iron accumulation in deep grey matter nuclei in Parkinson's disease : A cross-sectional study of iron-related magnetic resonance imaging susceptibility}},
url = {{http://dx.doi.org/10.1111/ene.13208}},
doi = {{10.1111/ene.13208}},
volume = {{24}},
year = {{2017}},
}