Posterior laryngitis: a disease with different aetiologies affecting health-related quality of life:a prospective case–control study
(2013) In BMC Ear, Nose and Throat Disorders 13(11).- Abstract
- Background: Laryngo-pharyngeal reflux (LPR) is assumed to be the most common cause of posterior laryngitis (PL).
Since LPR is found in healthy subjects, and PL patients are not improved by acid-reducing therapy, other
aetiologies to PL must be considered. The aims of this study in PL were to investigate the prevalence of acid reflux
in the proximal oesophagus and functional gastrointestinal symptoms, to analyse motilin levels in plasma, and to
assess health-related quality of life (HRQOL) before and after treatment.
Methods: Forty-six patients (26 women), with verified PL, median age 55 (IQR 41–68) years, were referred to
oesophago-gastro-duodenoscopy and 24-h pH monitoring. Plasma... (More) - Background: Laryngo-pharyngeal reflux (LPR) is assumed to be the most common cause of posterior laryngitis (PL).
Since LPR is found in healthy subjects, and PL patients are not improved by acid-reducing therapy, other
aetiologies to PL must be considered. The aims of this study in PL were to investigate the prevalence of acid reflux
in the proximal oesophagus and functional gastrointestinal symptoms, to analyse motilin levels in plasma, and to
assess health-related quality of life (HRQOL) before and after treatment.
Methods: Forty-six patients (26 women), with verified PL, median age 55 (IQR 41–68) years, were referred to
oesophago-gastro-duodenoscopy and 24-h pH monitoring. Plasma motilin was analysed. The 36-item Short-Form
questionnaire was completed at inclusion and at follow-up after 43±14 months, when also the Visual Analogue
Scale for Irritable Bowel Syndrome was completed. Values were compared to controls. Treatment and relief of
symptoms were noted from medical records.
Results: Thirty-four percent had proximal acid reflux and 40% showed signs of distal reflux. Ninety-four percent received
acid-reducing treatment, with total relief of symptoms in 17%. Patients with reflux symptoms had lower plasma motilin
levels compared to patients without reflux symptoms (p = 0.021). The HRQOL was impaired at inclusion, but improved
over time. Patients, especially men, had more functional gastrointestinal symptoms than controls.
Conclusions: This study indicates that a minority of patients with PL has LPR and is cured by acid-reducing therapy.
Disturbed plasma motilin levels and presence of functional gastrointestinal symptoms are found in PL. The impaired
HRQOL improves over time. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/5150252
- author
- Pendleton, Hillevi LU ; Ahlner-Elmqvist, Marianne LU ; Olsson, Rolf LU ; Thorsson, Ola LU ; Hammar, Oskar LU ; Jannert, Magnus LU and Ohlsson, Bodil LU
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Posterior laryngitis, Laryngo-pharyngeal reflux, Motilin, Functional gastrointestinal disorder, Health-related quality of life
- in
- BMC Ear, Nose and Throat Disorders
- volume
- 13
- issue
- 11
- publisher
- BioMed Central (BMC)
- external identifiers
-
- scopus:84885044790
- pmid:24015952
- ISSN
- 1472-6815
- DOI
- 10.1186/1472-6815-13-11
- language
- English
- LU publication?
- yes
- id
- d8dbb07d-e072-42b1-9cb7-062d655976bc (old id 5150252)
- date added to LUP
- 2016-04-01 14:37:55
- date last changed
- 2023-09-17 17:18:45
@article{d8dbb07d-e072-42b1-9cb7-062d655976bc,
abstract = {{Background: Laryngo-pharyngeal reflux (LPR) is assumed to be the most common cause of posterior laryngitis (PL).<br/><br>
Since LPR is found in healthy subjects, and PL patients are not improved by acid-reducing therapy, other<br/><br>
aetiologies to PL must be considered. The aims of this study in PL were to investigate the prevalence of acid reflux<br/><br>
in the proximal oesophagus and functional gastrointestinal symptoms, to analyse motilin levels in plasma, and to<br/><br>
assess health-related quality of life (HRQOL) before and after treatment.<br/><br>
Methods: Forty-six patients (26 women), with verified PL, median age 55 (IQR 41–68) years, were referred to<br/><br>
oesophago-gastro-duodenoscopy and 24-h pH monitoring. Plasma motilin was analysed. The 36-item Short-Form<br/><br>
questionnaire was completed at inclusion and at follow-up after 43±14 months, when also the Visual Analogue<br/><br>
Scale for Irritable Bowel Syndrome was completed. Values were compared to controls. Treatment and relief of<br/><br>
symptoms were noted from medical records.<br/><br>
Results: Thirty-four percent had proximal acid reflux and 40% showed signs of distal reflux. Ninety-four percent received<br/><br>
acid-reducing treatment, with total relief of symptoms in 17%. Patients with reflux symptoms had lower plasma motilin<br/><br>
levels compared to patients without reflux symptoms (p = 0.021). The HRQOL was impaired at inclusion, but improved<br/><br>
over time. Patients, especially men, had more functional gastrointestinal symptoms than controls.<br/><br>
Conclusions: This study indicates that a minority of patients with PL has LPR and is cured by acid-reducing therapy.<br/><br>
Disturbed plasma motilin levels and presence of functional gastrointestinal symptoms are found in PL. The impaired<br/><br>
HRQOL improves over time.}},
author = {{Pendleton, Hillevi and Ahlner-Elmqvist, Marianne and Olsson, Rolf and Thorsson, Ola and Hammar, Oskar and Jannert, Magnus and Ohlsson, Bodil}},
issn = {{1472-6815}},
keywords = {{Posterior laryngitis; Laryngo-pharyngeal reflux; Motilin; Functional gastrointestinal disorder; Health-related quality of life}},
language = {{eng}},
number = {{11}},
publisher = {{BioMed Central (BMC)}},
series = {{BMC Ear, Nose and Throat Disorders}},
title = {{Posterior laryngitis: a disease with different aetiologies affecting health-related quality of life:a prospective case–control study}},
url = {{https://lup.lub.lu.se/search/files/4074265/5150266.pdf}},
doi = {{10.1186/1472-6815-13-11}},
volume = {{13}},
year = {{2013}},
}