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In situ assembly of bioresorbable organic bioelectronics in the brain

Hjort, Martin LU orcid ; Mousa, Abdelrazek H. LU ; Bliman, David LU ; Shameem, Muhammad Anwar LU ; Hellman, Karin LU ; Yadav, Amit Singh LU ; Ekström, Peter LU ; Ek, Fredrik LU and Olsson, Roger LU orcid (2023) In Nature Communications 14(1).
Abstract

Bioelectronics can potentially complement classical therapies in nonchronic treatments, such as immunotherapy and cancer. In addition to functionality, minimally invasive implantation methods and bioresorbable materials are central to nonchronic treatments. The latter avoids the need for surgical removal after disease relief. Self-organizing substrate-free organic electrodes meet these criteria and integrate seamlessly into dynamic biological systems in ways difficult for classical rigid solid-state electronics. Here we place bioresorbable electrodes with a brain-matched shear modulus—made from water-dispersed nanoparticles in the brain—in the targeted area using a capillary thinner than a human hair. Thereafter, we show that an... (More)

Bioelectronics can potentially complement classical therapies in nonchronic treatments, such as immunotherapy and cancer. In addition to functionality, minimally invasive implantation methods and bioresorbable materials are central to nonchronic treatments. The latter avoids the need for surgical removal after disease relief. Self-organizing substrate-free organic electrodes meet these criteria and integrate seamlessly into dynamic biological systems in ways difficult for classical rigid solid-state electronics. Here we place bioresorbable electrodes with a brain-matched shear modulus—made from water-dispersed nanoparticles in the brain—in the targeted area using a capillary thinner than a human hair. Thereafter, we show that an optional auxiliary module grows dendrites from the installed conductive structure to seamlessly embed neurons and modify the electrode’s volume properties. We demonstrate that these soft electrodes set off a controlled cellular response in the brain when relaying external stimuli and that the biocompatible materials show no tissue damage after bioresorption. These findings encourage further investigation of temporary organic bioelectronics for nonchronic treatments assembled in vivo.

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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nature Communications
volume
14
issue
1
article number
4453
publisher
Nature Publishing Group
external identifiers
  • pmid:37488105
  • scopus:85165556967
ISSN
2041-1723
DOI
10.1038/s41467-023-40175-3
language
English
LU publication?
yes
additional info
Funding Information: This study was accomplished within the Lund University Strategic Research Areas MultiPark and NanoLund. We thank Dr. Xenofon Strakosas for assistance with interdigitated electrodes, Dr. Darcy Wagner for access to A549 cells, Dr. Sara Rolandsson Enes for HLF−1 cells, Dr. Bengt Mattsson for assistance with light sheet imaging, Dr. Yuriy Pomeshchik for access to fluorescence microscopes, and Dr. Cedric Dicko for assistance with mechanical testing. Equipment within Lund Nano Lab (LNL) and Lund University Bioimaging Centre (LBIC) was used to enable this research. R.O. acknowledges the financial support from Swedish Research Council (2018-05258, and 2018-06197), Swedish Foundation for Strategic Research (RMX18-0083), the Swedish Research Council 3 R, and MultiPark. M.H. acknowledges the financial support from The Swedish Research Council, the Crafoord Foundation, the Trygger Foundation, and the Royal Physiographic Society in Lund. Funding Information: This study was accomplished within the Lund University Strategic Research Areas MultiPark and NanoLund. We thank Dr. Xenofon Strakosas for assistance with interdigitated electrodes, Dr. Darcy Wagner for access to A549 cells, Dr. Sara Rolandsson Enes for HLF−1 cells, Dr. Bengt Mattsson for assistance with light sheet imaging, Dr. Yuriy Pomeshchik for access to fluorescence microscopes, and Dr. Cedric Dicko for assistance with mechanical testing. Equipment within Lund Nano Lab (LNL) and Lund University Bioimaging Centre (LBIC) was used to enable this research. R.O. acknowledges the financial support from Swedish Research Council (2018-05258, and 2018-06197), Swedish Foundation for Strategic Research (RMX18-0083), the Swedish Research Council 3 R, and MultiPark. M.H. acknowledges the financial support from The Swedish Research Council, the Crafoord Foundation, the Trygger Foundation, and the Royal Physiographic Society in Lund. Publisher Copyright: © 2023, The Author(s).
id
d9ae6374-5909-4f69-9259-855d696e0932
date added to LUP
2023-08-07 13:13:41
date last changed
2024-04-20 00:10:24
@article{d9ae6374-5909-4f69-9259-855d696e0932,
  abstract     = {{<p>Bioelectronics can potentially complement classical therapies in nonchronic treatments, such as immunotherapy and cancer. In addition to functionality, minimally invasive implantation methods and bioresorbable materials are central to nonchronic treatments. The latter avoids the need for surgical removal after disease relief. Self-organizing substrate-free organic electrodes meet these criteria and integrate seamlessly into dynamic biological systems in ways difficult for classical rigid solid-state electronics. Here we place bioresorbable electrodes with a brain-matched shear modulus—made from water-dispersed nanoparticles in the brain—in the targeted area using a capillary thinner than a human hair. Thereafter, we show that an optional auxiliary module grows dendrites from the installed conductive structure to seamlessly embed neurons and modify the electrode’s volume properties. We demonstrate that these soft electrodes set off a controlled cellular response in the brain when relaying external stimuli and that the biocompatible materials show no tissue damage after bioresorption. These findings encourage further investigation of temporary organic bioelectronics for nonchronic treatments assembled in vivo.</p>}},
  author       = {{Hjort, Martin and Mousa, Abdelrazek H. and Bliman, David and Shameem, Muhammad Anwar and Hellman, Karin and Yadav, Amit Singh and Ekström, Peter and Ek, Fredrik and Olsson, Roger}},
  issn         = {{2041-1723}},
  language     = {{eng}},
  number       = {{1}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Nature Communications}},
  title        = {{In situ assembly of bioresorbable organic bioelectronics in the brain}},
  url          = {{http://dx.doi.org/10.1038/s41467-023-40175-3}},
  doi          = {{10.1038/s41467-023-40175-3}},
  volume       = {{14}},
  year         = {{2023}},
}