Advanced

High levels of vitamin D associated with less ischemic heart disease – A nested case-control study among rural men in Sweden

Holmberg, Sara; Rignell-Hydbom, Anna LU ; Lindh, Christian H. LU ; Jönsson, Bo AG LU ; Thelin, Anders and Rylander, Lars LU (2017) In Annals of Agricultural and Environmental Medicine 24(2). p.288-293
Abstract

Introduction and objective. Low levels of serum vitamin D have been associated with increased occurrence of ischemic heart disease (IHD), but findings are inconsistent, e.g. seasonal variation is not always considered in the analyses. The aim of this study was to investigate whether vitamin D is associated with IHD among rural middle-aged men in Sweden when seasonal variation is taken into account. Materials and method. A nested case-control study was performed within a population-based cohort of Swedish farmers and rural residents followed for 20 years. Outcomes were from national health registers. For 276 cases (IHD at any time during follow-up), and for 276 aged-matched controls free of cardiovascular diseases or diabetes, serum... (More)

Introduction and objective. Low levels of serum vitamin D have been associated with increased occurrence of ischemic heart disease (IHD), but findings are inconsistent, e.g. seasonal variation is not always considered in the analyses. The aim of this study was to investigate whether vitamin D is associated with IHD among rural middle-aged men in Sweden when seasonal variation is taken into account. Materials and method. A nested case-control study was performed within a population-based cohort of Swedish farmers and rural residents followed for 20 years. Outcomes were from national health registers. For 276 cases (IHD at any time during follow-up), and for 276 aged-matched controls free of cardiovascular diseases or diabetes, serum levels of vitamin D (25-hydroxyvitamin D3) were analyzed with liquid chromatography/tandem mass spectrometry (LC/MS/MS), in stored blood samples drawn at the baseline survey in 1990–91. The odds ratio (OR) with 95% confidence intervals (CI) of IHD for vitamin D-quartiles (based on measured as well as adjusted for month of sampling) was evaluated in logistic regression models; potential confounders were taken into account. Results. The measured mean vitamin D levels were 27.6 ng/ml(standard deviation (sd)8.2 ng/ml) and 28.8 ng/ml (sd 9.0) among cases and controls, respectively. Compared to the quartile with the lowest month-adjusted vitamin D levels, the risk of IHD was significantly lower in the highest quartile (OR=0.46, 95% CI 0.25–0.84, p=0.012) in the fully-adjusted model. Conclusion. Rural Swedish men in the highest quartile of serum vitamin D had halved relative risk of IHD, compared to those in the lowest quartile.

(Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
25-hydroxyvitamin D, Agriculture, Coronary heart disease, Prospective study, Seasonal variation
in
Annals of Agricultural and Environmental Medicine
volume
24
issue
2
pages
6 pages
publisher
Institute of Agricultural Medicine in Lublin, Poland
external identifiers
  • scopus:85020986106
  • wos:000403506900025
ISSN
1232-1966
DOI
10.5604/12321966.1235176
language
English
LU publication?
yes
id
dada1263-e8fd-41dd-8c42-a5e338604e89
date added to LUP
2017-08-18 13:57:14
date last changed
2017-09-18 11:42:06
@article{dada1263-e8fd-41dd-8c42-a5e338604e89,
  abstract     = {<p>Introduction and objective. Low levels of serum vitamin D have been associated with increased occurrence of ischemic heart disease (IHD), but findings are inconsistent, e.g. seasonal variation is not always considered in the analyses. The aim of this study was to investigate whether vitamin D is associated with IHD among rural middle-aged men in Sweden when seasonal variation is taken into account. Materials and method. A nested case-control study was performed within a population-based cohort of Swedish farmers and rural residents followed for 20 years. Outcomes were from national health registers. For 276 cases (IHD at any time during follow-up), and for 276 aged-matched controls free of cardiovascular diseases or diabetes, serum levels of vitamin D (25-hydroxyvitamin D<sub>3</sub>) were analyzed with liquid chromatography/tandem mass spectrometry (LC/MS/MS), in stored blood samples drawn at the baseline survey in 1990–91. The odds ratio (OR) with 95% confidence intervals (CI) of IHD for vitamin D-quartiles (based on measured as well as adjusted for month of sampling) was evaluated in logistic regression models; potential confounders were taken into account. Results. The measured mean vitamin D levels were 27.6 ng/ml(standard deviation (sd)8.2 ng/ml) and 28.8 ng/ml (sd 9.0) among cases and controls, respectively. Compared to the quartile with the lowest month-adjusted vitamin D levels, the risk of IHD was significantly lower in the highest quartile (OR=0.46, 95% CI 0.25–0.84, p=0.012) in the fully-adjusted model. Conclusion. Rural Swedish men in the highest quartile of serum vitamin D had halved relative risk of IHD, compared to those in the lowest quartile.</p>},
  author       = {Holmberg, Sara and Rignell-Hydbom, Anna and Lindh, Christian H. and Jönsson, Bo AG and Thelin, Anders and Rylander, Lars},
  issn         = {1232-1966},
  keyword      = {25-hydroxyvitamin D,Agriculture,Coronary heart disease,Prospective study,Seasonal variation},
  language     = {eng},
  number       = {2},
  pages        = {288--293},
  publisher    = {Institute of Agricultural Medicine in Lublin, Poland},
  series       = {Annals of Agricultural and Environmental Medicine},
  title        = {High levels of vitamin D associated with less ischemic heart disease – A nested case-control study among rural men in Sweden},
  url          = {http://dx.doi.org/10.5604/12321966.1235176},
  volume       = {24},
  year         = {2017},
}