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Persistent production of neurons from adult brain stem cells during recovery after stroke.

Thored, Per ; Arvidsson, Andreas LU ; Cacci, Emanuele LU ; Ahlenius, Henrik LU ; Kallur, Therese LU ; Darsalia, Vladimer LU ; Ekdahl Clementson, Christine LU ; Kokaia, Zaal LU and Lindvall, Olle LU (2006) In Stem Cells 24(3). p.739-747
Abstract
Neural stem cells in the subventricular zone of adult rodents produce new striatal neurons that may replace those that have died after stroke; however, the neurogenic response has been considered acute and transient, yielding only small numbers of neurons. In contrast, we show herein that striatal neuroblasts are generated without decline at least for 4 months after stroke in adult rats. Neuroblasts formed early or late after stroke either differentiate into mature neurons, which survive for several months, or die through caspase-mediated apoptosis. The directed migration of the new neurons toward the ischemic damage is regulated by stromal cell-derived factor-la and its receptor CXCR4. These results show that endogenous neural stem cells... (More)
Neural stem cells in the subventricular zone of adult rodents produce new striatal neurons that may replace those that have died after stroke; however, the neurogenic response has been considered acute and transient, yielding only small numbers of neurons. In contrast, we show herein that striatal neuroblasts are generated without decline at least for 4 months after stroke in adult rats. Neuroblasts formed early or late after stroke either differentiate into mature neurons, which survive for several months, or die through caspase-mediated apoptosis. The directed migration of the new neurons toward the ischemic damage is regulated by stromal cell-derived factor-la and its receptor CXCR4. These results show that endogenous neural stem cells continuously supply the injured adult brain with new neurons, which suggests novel self-repair strategies to improve recovery after stroke. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
striatum, neurogenesis, stroke, stem cells
in
Stem Cells
volume
24
issue
3
pages
739 - 747
publisher
AlphaMed Press
external identifiers
  • wos:000240636200030
  • pmid:16210404
  • scopus:33745001464
  • pmid:16210404
ISSN
1549-4918
DOI
10.1634/stemcells.2005-0281
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Restorative Neurology (0131000160), Stem Cell Center (013041110), Neurology, Lund (013027000)
id
db1cef74-a259-466a-9ccc-5916acc59d40 (old id 144781)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16210404&dopt=Abstract
date added to LUP
2016-04-01 16:28:01
date last changed
2020-02-19 03:34:10
@article{db1cef74-a259-466a-9ccc-5916acc59d40,
  abstract     = {Neural stem cells in the subventricular zone of adult rodents produce new striatal neurons that may replace those that have died after stroke; however, the neurogenic response has been considered acute and transient, yielding only small numbers of neurons. In contrast, we show herein that striatal neuroblasts are generated without decline at least for 4 months after stroke in adult rats. Neuroblasts formed early or late after stroke either differentiate into mature neurons, which survive for several months, or die through caspase-mediated apoptosis. The directed migration of the new neurons toward the ischemic damage is regulated by stromal cell-derived factor-la and its receptor CXCR4. These results show that endogenous neural stem cells continuously supply the injured adult brain with new neurons, which suggests novel self-repair strategies to improve recovery after stroke.},
  author       = {Thored, Per and Arvidsson, Andreas and Cacci, Emanuele and Ahlenius, Henrik and Kallur, Therese and Darsalia, Vladimer and Ekdahl Clementson, Christine and Kokaia, Zaal and Lindvall, Olle},
  issn         = {1549-4918},
  language     = {eng},
  number       = {3},
  pages        = {739--747},
  publisher    = {AlphaMed Press},
  series       = {Stem Cells},
  title        = {Persistent production of neurons from adult brain stem cells during recovery after stroke.},
  url          = {http://dx.doi.org/10.1634/stemcells.2005-0281},
  doi          = {10.1634/stemcells.2005-0281},
  volume       = {24},
  year         = {2006},
}