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Oxidation of marine oils during in vitro gastrointestinal digestion with human digestive fluids - Role of oil origin, added tocopherols and lipolytic activity

Tullberg, Cecilia LU ; Vegarud, Gerd and Undeland, Ingrid (2019) In Food Chemistry 270. p.527-537
Abstract

The formation of malondialdehyde (MDA), 4-hydroxy-2-hexenal (HHE), 4-hydroxy-2-nonenal (HNE), and 4-oxo-2-nonenal (ONE) in cod liver-, anchovy-, krill-, and algae oil during in vitro digestion with human gastrointestinal fluids was investigated. Adding rabbit gastric lipase, lipase inhibitor (orlistat) and tocopherols to cod liver oil, lipolysis and oxidation was also studied. Among the marine oils, the highest aldehyde levels (18 µM MDA, 3 µM HHE and 0.2 µM HNE) were detected after digestion of cod liver oil, while the lowest levels were detected in krill and algae oils. Addition of rabbit gastric lipase significantly increased the release of HNE during the digestion. Orlistat significantly reduced lipolysis and MDA formation.... (More)

The formation of malondialdehyde (MDA), 4-hydroxy-2-hexenal (HHE), 4-hydroxy-2-nonenal (HNE), and 4-oxo-2-nonenal (ONE) in cod liver-, anchovy-, krill-, and algae oil during in vitro digestion with human gastrointestinal fluids was investigated. Adding rabbit gastric lipase, lipase inhibitor (orlistat) and tocopherols to cod liver oil, lipolysis and oxidation was also studied. Among the marine oils, the highest aldehyde levels (18 µM MDA, 3 µM HHE and 0.2 µM HNE) were detected after digestion of cod liver oil, while the lowest levels were detected in krill and algae oils. Addition of rabbit gastric lipase significantly increased the release of HNE during the digestion. Orlistat significantly reduced lipolysis and MDA formation. Formation of MDA and HHE was delayed by tocopherols, the tocopherol mix Covi-ox® T 70 EU being more effective than pure α-tocopherol.

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author
publishing date
type
Contribution to journal
publication status
published
keywords
Aldehydes/metabolism, Animals, Digestion, Fish Oils/analysis, Humans, Malondialdehyde/metabolism, Models, Biological, Oils, Oxidation-Reduction, Rabbits, Tocopherols
in
Food Chemistry
volume
270
pages
11 pages
publisher
Elsevier
external identifiers
  • scopus:85050332643
ISSN
1873-7072
DOI
10.1016/j.foodchem.2018.07.049
language
English
LU publication?
no
id
dc9268fd-f168-4766-85c9-72c308e53f5b
date added to LUP
2019-07-01 16:23:01
date last changed
2019-10-15 07:10:02
@article{dc9268fd-f168-4766-85c9-72c308e53f5b,
  abstract     = {<p>The formation of malondialdehyde (MDA), 4-hydroxy-2-hexenal (HHE), 4-hydroxy-2-nonenal (HNE), and 4-oxo-2-nonenal (ONE) in cod liver-, anchovy-, krill-, and algae oil during in vitro digestion with human gastrointestinal fluids was investigated. Adding rabbit gastric lipase, lipase inhibitor (orlistat) and tocopherols to cod liver oil, lipolysis and oxidation was also studied. Among the marine oils, the highest aldehyde levels (18 µM MDA, 3 µM HHE and 0.2 µM HNE) were detected after digestion of cod liver oil, while the lowest levels were detected in krill and algae oils. Addition of rabbit gastric lipase significantly increased the release of HNE during the digestion. Orlistat significantly reduced lipolysis and MDA formation. Formation of MDA and HHE was delayed by tocopherols, the tocopherol mix Covi-ox® T 70 EU being more effective than pure α-tocopherol.</p>},
  author       = {Tullberg, Cecilia and Vegarud, Gerd and Undeland, Ingrid},
  issn         = {1873-7072},
  keyword      = {Aldehydes/metabolism,Animals,Digestion,Fish Oils/analysis,Humans,Malondialdehyde/metabolism,Models, Biological,Oils,Oxidation-Reduction,Rabbits,Tocopherols},
  language     = {eng},
  month        = {01},
  pages        = {527--537},
  publisher    = {Elsevier},
  series       = {Food Chemistry},
  title        = {Oxidation of marine oils during in vitro gastrointestinal digestion with human digestive fluids - Role of oil origin, added tocopherols and lipolytic activity},
  url          = {http://dx.doi.org/10.1016/j.foodchem.2018.07.049},
  volume       = {270},
  year         = {2019},
}