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The association between the intake of specific dietary components and lifestyle factors and microscopic colitis

Larsson, J. K. LU ; Sonestedt, E. LU ; Ohlsson, B. LU ; Manjer, J. LU and Sjöberg, K. LU (2016) In European Journal of Clinical Nutrition 70(11). p.1309-1317
Abstract

Background/Objectives:The incidence of microscopic colitis (MC) has increased over the previous decades. In addition to smoking and drugs, currently unidentified environmental factors may have a role. The aim of this study was to determine whether specific dietary or other lifestyle factors were associated with the development of MC.Subject/Methods:The population-based cohort Malmö Diet and Cancer Study of 28 095 individuals was examined. Information about dietary habits was collected by a modified diet history method. Data on anthropometry were measured, and socio-economic and lifestyle factors were collected by questionnaires. Cases of MC were identified in medical registers. Associations were estimated using Cox regression... (More)

Background/Objectives:The incidence of microscopic colitis (MC) has increased over the previous decades. In addition to smoking and drugs, currently unidentified environmental factors may have a role. The aim of this study was to determine whether specific dietary or other lifestyle factors were associated with the development of MC.Subject/Methods:The population-based cohort Malmö Diet and Cancer Study of 28 095 individuals was examined. Information about dietary habits was collected by a modified diet history method. Data on anthropometry were measured, and socio-economic and lifestyle factors were collected by questionnaires. Cases of MC were identified in medical registers. Associations were estimated using Cox regression analysis.Results:During a 22-year period, 135 patients were diagnosed with MC. Intakes of protein, carbohydrates, sucrose, saturated fat, monounsaturated fat, polyunsaturated fat, omega-3 or omega-6 fatty acids, fibre and zinc were not associated with MC. We could verify the previously reported association between MC and smoking (hazard ratio (HR): 2.29; 95% confidence interval (CI): 1.66–3.84) and the female gender (HR: 3.57; 95% CI: 2.22–5.74). High alcohol consumption was associated with an increased risk for MC (HR: 1.89 for the highest quartile; 95% CI: 0.82–4.33, P for trend=0.032). In a post hoc analysis, alcohol intake including all patients independently of consumption seemed to reduce the smoking-related risk.Conclusions:Despite a large cohort and a long follow-up period, we could not detect any dietary risk factors for MC. The aetiological mechanisms behind the positive impact of smoking and alcohol on MC risk should be investigated.European Journal of Clinical Nutrition advance online publication, 27 July 2016; doi:10.1038/ejcn.2016.130.

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author
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type
Contribution to journal
publication status
published
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in
European Journal of Clinical Nutrition
volume
70
issue
11
pages
1309 - 1317
publisher
Nature Publishing Group
external identifiers
  • Scopus:84979609033
ISSN
0954-3007
DOI
10.1038/ejcn.2016.130
language
English
LU publication?
yes
id
dfdfc2b6-2bd5-43a5-82ef-00dacede8882
date added to LUP
2016-08-29 14:42:31
date last changed
2017-01-18 09:52:52
@article{dfdfc2b6-2bd5-43a5-82ef-00dacede8882,
  abstract     = {<p>Background/Objectives:The incidence of microscopic colitis (MC) has increased over the previous decades. In addition to smoking and drugs, currently unidentified environmental factors may have a role. The aim of this study was to determine whether specific dietary or other lifestyle factors were associated with the development of MC.Subject/Methods:The population-based cohort Malmö Diet and Cancer Study of 28 095 individuals was examined. Information about dietary habits was collected by a modified diet history method. Data on anthropometry were measured, and socio-economic and lifestyle factors were collected by questionnaires. Cases of MC were identified in medical registers. Associations were estimated using Cox regression analysis.Results:During a 22-year period, 135 patients were diagnosed with MC. Intakes of protein, carbohydrates, sucrose, saturated fat, monounsaturated fat, polyunsaturated fat, omega-3 or omega-6 fatty acids, fibre and zinc were not associated with MC. We could verify the previously reported association between MC and smoking (hazard ratio (HR): 2.29; 95% confidence interval (CI): 1.66–3.84) and the female gender (HR: 3.57; 95% CI: 2.22–5.74). High alcohol consumption was associated with an increased risk for MC (HR: 1.89 for the highest quartile; 95% CI: 0.82–4.33, P for trend=0.032). In a post hoc analysis, alcohol intake including all patients independently of consumption seemed to reduce the smoking-related risk.Conclusions:Despite a large cohort and a long follow-up period, we could not detect any dietary risk factors for MC. The aetiological mechanisms behind the positive impact of smoking and alcohol on MC risk should be investigated.European Journal of Clinical Nutrition advance online publication, 27 July 2016; doi:10.1038/ejcn.2016.130.</p>},
  author       = {Larsson, J. K. and Sonestedt, E. and Ohlsson, B. and Manjer, J. and Sjöberg, K.},
  issn         = {0954-3007},
  language     = {eng},
  number       = {11},
  pages        = {1309--1317},
  publisher    = {Nature Publishing Group},
  series       = {European Journal of Clinical Nutrition},
  title        = {The association between the intake of specific dietary components and lifestyle factors and microscopic colitis},
  url          = {http://dx.doi.org/10.1038/ejcn.2016.130},
  volume       = {70},
  year         = {2016},
}