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Dynamics of the blood plasma proteome during hyperacute HIV-1 infection

Nazziwa, Jamirah LU orcid ; Freyhult, Eva ; Hong, Mun Gwan ; Johansson, Emil LU orcid ; Årman, Filip LU ; Hare, Jonathan ; Gounder, Kamini ; Rezeli, Melinda LU orcid ; Mohanty, Tirthankar LU and Kjellström, Sven LU , et al. (2024) In Nature Communications 15(1).
Abstract

The complex dynamics of protein expression in plasma during hyperacute HIV-1 infection and its relation to acute retroviral syndrome, viral control, and disease progression are largely unknown. Here, we quantify 1293 blood plasma proteins from 157 longitudinally linked plasma samples collected before, during, and after hyperacute HIV-1 infection of 54 participants from four sub-Saharan African countries. Six distinct longitudinal expression profiles are identified, of which four demonstrate a consistent decrease in protein levels following HIV-1 infection. Proteins involved in inflammatory responses, immune regulation, and cell motility are significantly altered during the transition from pre-infection to one month post-infection.... (More)

The complex dynamics of protein expression in plasma during hyperacute HIV-1 infection and its relation to acute retroviral syndrome, viral control, and disease progression are largely unknown. Here, we quantify 1293 blood plasma proteins from 157 longitudinally linked plasma samples collected before, during, and after hyperacute HIV-1 infection of 54 participants from four sub-Saharan African countries. Six distinct longitudinal expression profiles are identified, of which four demonstrate a consistent decrease in protein levels following HIV-1 infection. Proteins involved in inflammatory responses, immune regulation, and cell motility are significantly altered during the transition from pre-infection to one month post-infection. Specifically, decreased ZYX and SCGB1A1 levels, and increased LILRA3 levels are associated with increased risk of acute retroviral syndrome; increased NAPA and RAN levels, and decreased ITIH4 levesls with viral control; and increased HPN, PRKCB, and ITGB3 levels with increased risk of disease progression. Overall, this study provides insight into early host responses in hyperacute HIV-1 infection, and present potential biomarkers and mechanisms linked to HIV-1 disease progression and viral load.

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publishing date
type
Contribution to journal
publication status
published
subject
in
Nature Communications
volume
15
issue
1
article number
10593
publisher
Nature Publishing Group
external identifiers
  • pmid:39632834
  • scopus:85210933875
ISSN
2041-1723
DOI
10.1038/s41467-024-54848-0
language
English
LU publication?
yes
id
ed859e36-d704-40d3-81bc-f3ae27714464
date added to LUP
2025-01-20 13:29:07
date last changed
2025-07-08 03:01:31
@article{ed859e36-d704-40d3-81bc-f3ae27714464,
  abstract     = {{<p>The complex dynamics of protein expression in plasma during hyperacute HIV-1 infection and its relation to acute retroviral syndrome, viral control, and disease progression are largely unknown. Here, we quantify 1293 blood plasma proteins from 157 longitudinally linked plasma samples collected before, during, and after hyperacute HIV-1 infection of 54 participants from four sub-Saharan African countries. Six distinct longitudinal expression profiles are identified, of which four demonstrate a consistent decrease in protein levels following HIV-1 infection. Proteins involved in inflammatory responses, immune regulation, and cell motility are significantly altered during the transition from pre-infection to one month post-infection. Specifically, decreased ZYX and SCGB1A1 levels, and increased LILRA3 levels are associated with increased risk of acute retroviral syndrome; increased NAPA and RAN levels, and decreased ITIH4 levesls with viral control; and increased HPN, PRKCB, and ITGB3 levels with increased risk of disease progression. Overall, this study provides insight into early host responses in hyperacute HIV-1 infection, and present potential biomarkers and mechanisms linked to HIV-1 disease progression and viral load.</p>}},
  author       = {{Nazziwa, Jamirah and Freyhult, Eva and Hong, Mun Gwan and Johansson, Emil and Årman, Filip and Hare, Jonathan and Gounder, Kamini and Rezeli, Melinda and Mohanty, Tirthankar and Kjellström, Sven and Kamali, Anatoli and Karita, Etienne and Kilembe, William and Price, Matt A. and Kaleebu, Pontiano and Allen, Susan and Hunter, Eric and Ndung’u, Thumbi and Gilmour, Jill and Rowland-Jones, Sarah L. and Sanders, Eduard and Hassan, Amin S. and Esbjörnsson, Joakim}},
  issn         = {{2041-1723}},
  language     = {{eng}},
  number       = {{1}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Nature Communications}},
  title        = {{Dynamics of the blood plasma proteome during hyperacute HIV-1 infection}},
  url          = {{http://dx.doi.org/10.1038/s41467-024-54848-0}},
  doi          = {{10.1038/s41467-024-54848-0}},
  volume       = {{15}},
  year         = {{2024}},
}