A study of size-selective renal elimination using a novel human model
(2024) In Scandinavian Journal of Clinical & Laboratory Investigation p.1-6- Abstract
- The recently discovered selective glomerular hypofiltration syndromes have increased interest in the actual elimination of molecules in the human kidney. In the present study, a novel human model was introduced to directly measure the single-pass renal elimination of molecules of increasing size. Plasma concentrations of urea, creatinine, C-peptide, insulin, pro-BNP, β2-microglobulin, cystatin C, troponin-T, orosomucoid, albumin, and IgG were analysed in arterial and renal venous blood from 45 patients
undergoing Transcatheter Aortic Valve Implantation (TA VI). The renal elimination ratio (RER) was calculated as the arteriovenous concentration difference divided by the arterial concentration. Estimated glomerular filtration rate (eGFR)... (More) - The recently discovered selective glomerular hypofiltration syndromes have increased interest in the actual elimination of molecules in the human kidney. In the present study, a novel human model was introduced to directly measure the single-pass renal elimination of molecules of increasing size. Plasma concentrations of urea, creatinine, C-peptide, insulin, pro-BNP, β2-microglobulin, cystatin C, troponin-T, orosomucoid, albumin, and IgG were analysed in arterial and renal venous blood from 45 patients
undergoing Transcatheter Aortic Valve Implantation (TA VI). The renal elimination ratio (RER) was calculated as the arteriovenous concentration difference divided by the arterial concentration. Estimated glomerular filtration rate (eGFR) was calculated by the CKD-EPI equations for both creatinine and cystatin C. Creatinine (0.11 kDa) showed the highest RER (21.0 ± 6.3%). With increasing molecular size, the RER gradually decreased, where the RER of cystatin C (13 kDa) was 14.4 ± 5.3% and troponin-T (36 kDa) was 11.3 ± 4.6%. The renal elimination threshold was found between 36 and 44 kDa as the RER of orosomucoid (44 kDa) was −0.2 ± 4.7%. The RER of creatinine and cystatin C showed a significant and moderate positive linear relationship with eGFR (r = 0.48 and 0.40). In conclusion, a novel human model was employed to demonstrate a decline in renal elimination with increasing molecularsize. Moreover, RERs of creatinine and cystatin C were found to correlate with eGFR, suggesting the potential of this model to study selective glomerular hypofiltration syndromes. (Less)
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- author
- organization
-
- Thoracic Surgery
- Pediatric anesthesia and intensive care (research group)
- Cystatin C, renal disease, amyloidosis and antibiotics (research group)
- Internal Medicine - Epidemiology (research group)
- EpiHealth: Epidemiology for Health
- Renal physiology and peritoneal dialysis (research group)
- Cardiothoracic anesthesia and intensive care (research group)
- Less invasive cardiac surgery (research group)
- Molecular Cardiology (research group)
- Cardiology
- Cardiac Inflammation Research Group (research group)
- Artificial Intelligence and Bioinformatics in Cardiothoracic Sciences (AIBCTS) (research group)
- publishing date
- 2024-04-08
- type
- Contribution to journal
- publication status
- epub
- subject
- in
- Scandinavian Journal of Clinical & Laboratory Investigation
- pages
- 1 - 6
- publisher
- Informa Healthcare
- external identifiers
-
- pmid:38587086
- ISSN
- 1502-7686
- DOI
- 10.1080/00365513.2024.2338742
- language
- English
- LU publication?
- yes
- id
- edd585e3-a90b-41b4-b3d2-9e63b77d6514
- date added to LUP
- 2024-04-11 17:00:30
- date last changed
- 2024-04-12 10:29:17
@article{edd585e3-a90b-41b4-b3d2-9e63b77d6514, abstract = {{The recently discovered selective glomerular hypofiltration syndromes have increased interest in the actual elimination of molecules in the human kidney. In the present study, a novel human model was introduced to directly measure the single-pass renal elimination of molecules of increasing size. Plasma concentrations of urea, creatinine, C-peptide, insulin, pro-BNP, β2-microglobulin, cystatin C, troponin-T, orosomucoid, albumin, and IgG were analysed in arterial and renal venous blood from 45 patients<br/>undergoing Transcatheter Aortic Valve Implantation (TA VI). The renal elimination ratio (RER) was calculated as the arteriovenous concentration difference divided by the arterial concentration. Estimated glomerular filtration rate (eGFR) was calculated by the CKD-EPI equations for both creatinine and cystatin C. Creatinine (0.11 kDa) showed the highest RER (21.0 ± 6.3%). With increasing molecular size, the RER gradually decreased, where the RER of cystatin C (13 kDa) was 14.4 ± 5.3% and troponin-T (36 kDa) was 11.3 ± 4.6%. The renal elimination threshold was found between 36 and 44 kDa as the RER of orosomucoid (44 kDa) was −0.2 ± 4.7%. The RER of creatinine and cystatin C showed a significant and moderate positive linear relationship with eGFR (r = 0.48 and 0.40). In conclusion, a novel human model was employed to demonstrate a decline in renal elimination with increasing molecularsize. Moreover, RERs of creatinine and cystatin C were found to correlate with eGFR, suggesting the potential of this model to study selective glomerular hypofiltration syndromes.}}, author = {{Sigurjonsson, Johann and Grubb, David and Grubb, Anders and Christensson, Anders and Öberg, Carl and Ederoth, Per and Koul, Sasha and Götberg, Matthias and Yndigegn, Troels and Tödt, Tim and Viterius, Benedicte and Bjursten, Henrik}}, issn = {{1502-7686}}, language = {{eng}}, month = {{04}}, pages = {{1--6}}, publisher = {{Informa Healthcare}}, series = {{Scandinavian Journal of Clinical & Laboratory Investigation}}, title = {{A study of size-selective renal elimination using a novel human model}}, url = {{http://dx.doi.org/10.1080/00365513.2024.2338742}}, doi = {{10.1080/00365513.2024.2338742}}, year = {{2024}}, }