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A study of size-selective renal elimination using a novel human model

Sigurjonsson, Johann LU ; Grubb, David LU ; Grubb, Anders LU orcid ; Christensson, Anders LU ; Öberg, Carl LU ; Ederoth, Per LU ; Koul, Sasha LU ; Götberg, Matthias LU ; Yndigegn, Troels LU and Tödt, Tim LU , et al. (2024) In Scandinavian Journal of Clinical & Laboratory Investigation p.1-6
Abstract
The recently discovered selective glomerular hypofiltration syndromes have increased interest in the actual elimination of molecules in the human kidney. In the present study, a novel human model was introduced to directly measure the single-pass renal elimination of molecules of increasing size. Plasma concentrations of urea, creatinine, C-peptide, insulin, pro-BNP, β2-microglobulin, cystatin C, troponin-T, orosomucoid, albumin, and IgG were analysed in arterial and renal venous blood from 45 patients
undergoing Transcatheter Aortic Valve Implantation (TA VI). The renal elimination ratio (RER) was calculated as the arteriovenous concentration difference divided by the arterial concentration. Estimated glomerular filtration rate (eGFR)... (More)
The recently discovered selective glomerular hypofiltration syndromes have increased interest in the actual elimination of molecules in the human kidney. In the present study, a novel human model was introduced to directly measure the single-pass renal elimination of molecules of increasing size. Plasma concentrations of urea, creatinine, C-peptide, insulin, pro-BNP, β2-microglobulin, cystatin C, troponin-T, orosomucoid, albumin, and IgG were analysed in arterial and renal venous blood from 45 patients
undergoing Transcatheter Aortic Valve Implantation (TA VI). The renal elimination ratio (RER) was calculated as the arteriovenous concentration difference divided by the arterial concentration. Estimated glomerular filtration rate (eGFR) was calculated by the CKD-EPI equations for both creatinine and cystatin C. Creatinine (0.11 kDa) showed the highest RER (21.0 ± 6.3%). With increasing molecular size, the RER gradually decreased, where the RER of cystatin C (13 kDa) was 14.4 ± 5.3% and troponin-T (36 kDa) was 11.3 ± 4.6%. The renal elimination threshold was found between 36 and 44 kDa as the RER of orosomucoid (44 kDa) was −0.2 ± 4.7%. The RER of creatinine and cystatin C showed a significant and moderate positive linear relationship with eGFR (r = 0.48 and 0.40). In conclusion, a novel human model was employed to demonstrate a decline in renal elimination with increasing molecularsize. Moreover, RERs of creatinine and cystatin C were found to correlate with eGFR, suggesting the potential of this model to study selective glomerular hypofiltration syndromes. (Less)
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organization
publishing date
type
Contribution to journal
publication status
epub
subject
in
Scandinavian Journal of Clinical & Laboratory Investigation
pages
1 - 6
publisher
Informa Healthcare
external identifiers
  • pmid:38587086
ISSN
1502-7686
DOI
10.1080/00365513.2024.2338742
language
English
LU publication?
yes
id
edd585e3-a90b-41b4-b3d2-9e63b77d6514
date added to LUP
2024-04-11 17:00:30
date last changed
2024-04-12 10:29:17
@article{edd585e3-a90b-41b4-b3d2-9e63b77d6514,
  abstract     = {{The recently discovered selective glomerular hypofiltration syndromes have increased interest in the actual elimination of molecules in the human kidney. In the present study, a novel human model was introduced to directly measure the single-pass renal elimination of molecules of increasing size. Plasma concentrations of urea, creatinine, C-peptide, insulin, pro-BNP, β2-microglobulin, cystatin C, troponin-T, orosomucoid, albumin, and IgG were analysed in arterial and renal venous blood from 45 patients<br/>undergoing Transcatheter Aortic Valve Implantation (TA VI). The renal elimination ratio (RER) was calculated as the arteriovenous concentration difference divided by the arterial concentration. Estimated glomerular filtration rate (eGFR) was calculated by the CKD-EPI equations for both creatinine and cystatin C. Creatinine (0.11 kDa) showed the highest RER (21.0 ± 6.3%). With increasing molecular size, the RER gradually decreased, where the RER of cystatin C (13 kDa) was 14.4 ± 5.3% and troponin-T (36 kDa) was 11.3 ± 4.6%. The renal elimination threshold was found between 36 and 44 kDa as the RER of orosomucoid (44 kDa) was −0.2 ± 4.7%. The RER of creatinine and cystatin C showed a significant and moderate positive linear relationship with eGFR (r = 0.48 and 0.40). In conclusion, a novel human model was employed to demonstrate a decline in renal elimination with increasing molecularsize. Moreover, RERs of creatinine and cystatin C were found to correlate with eGFR, suggesting the potential of this model to study selective glomerular hypofiltration syndromes.}},
  author       = {{Sigurjonsson, Johann and Grubb, David and Grubb, Anders and Christensson, Anders and Öberg, Carl and Ederoth, Per and Koul, Sasha and Götberg, Matthias and Yndigegn, Troels and Tödt, Tim and Viterius, Benedicte and Bjursten, Henrik}},
  issn         = {{1502-7686}},
  language     = {{eng}},
  month        = {{04}},
  pages        = {{1--6}},
  publisher    = {{Informa Healthcare}},
  series       = {{Scandinavian Journal of Clinical & Laboratory Investigation}},
  title        = {{A study of size-selective renal elimination using a novel human model}},
  url          = {{http://dx.doi.org/10.1080/00365513.2024.2338742}},
  doi          = {{10.1080/00365513.2024.2338742}},
  year         = {{2024}},
}