Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Quantitative trait loci mapping of functional traits in the german Holstein cattle population

Kühn, Ch ; Bennewitz, J. ; Reinsch, N. ; Xu, N. ; Thomsen, H. LU orcid ; Looft, C. ; Brockmann, G. A. ; Schwerin, M. ; Weimann, C. and Hiendleder, S. , et al. (2003) In Journal of Dairy Science 86(1). p.360-368
Abstract

A whole-genome scan to detect quantitative trait loci (QTL) for functional traits was performed in the German Holstein cattle population. For this purpose, 263 genetic markers across all autosomes and the pseudoautosomal region of the sex chromosomes were genotyped in 16 granddaughter-design families with 872 sons. The traits investigated were deregressed breeding values for maternal and direct effects on dystocia (DYSm, DYSd) and still-birth (STIm, STId) as well as maternal and paternal effects on nonreturn rates of 90 d (NR90m, NR90p). Furthermore, deregressed breeding values for functional herd life (FHL) and daughter yield deviation for somatic cell count (SCC) were... (More)

A whole-genome scan to detect quantitative trait loci (QTL) for functional traits was performed in the German Holstein cattle population. For this purpose, 263 genetic markers across all autosomes and the pseudoautosomal region of the sex chromosomes were genotyped in 16 granddaughter-design families with 872 sons. The traits investigated were deregressed breeding values for maternal and direct effects on dystocia (DYSm, DYSd) and still-birth (STIm, STId) as well as maternal and paternal effects on nonreturn rates of 90 d (NR90m, NR90p). Furthermore, deregressed breeding values for functional herd life (FHL) and daughter yield deviation for somatic cell count (SCC) were investigated. Weighted multimarker regression analyses across families and permutation tests were applied for the detection of QTL and the calculation of statistical significance. A ten percent genomewise significant QTL was localized for DYSm on chromosome 8 and for SCC on chromosome 18. A further 24 putative QTL exceeding the 5% chromosomewise threshold were detected. On chromosomes 7, 8, 10, 18, and X/Yps, coincidence of QTL for several traits was observed. Our results suggest that loci with influence on udder health may also contribute to genetic variance of longevity. Prior to implementation of these QTL in marker assisted selection programs for functional traits, information about direct and correlated effects of these QTL as well as fine mapping of their chromosomal positions is required.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; ; and , et al. (More)
; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; and (Less)
publishing date
type
Contribution to journal
publication status
published
keywords
Functional traits, Holstein cattle, Quantitative trait loci
in
Journal of Dairy Science
volume
86
issue
1
pages
9 pages
publisher
American Dairy Science Association
external identifiers
  • scopus:4043162145
  • pmid:12613879
ISSN
0022-0302
DOI
10.3168/jds.S0022-0302(03)73614-5
language
English
LU publication?
no
id
eebc3e4a-ee52-468c-beff-5dd5bf55db2d
date added to LUP
2018-10-10 13:38:45
date last changed
2024-06-10 19:28:02
@article{eebc3e4a-ee52-468c-beff-5dd5bf55db2d,
  abstract     = {{<p>A whole-genome scan to detect quantitative trait loci (QTL) for functional traits was performed in the German Holstein cattle population. For this purpose, 263 genetic markers across all autosomes and the pseudoautosomal region of the sex chromosomes were genotyped in 16 granddaughter-design families with 872 sons. The traits investigated were deregressed breeding values for maternal and direct effects on dystocia (DYS<sub>m</sub>, DYS<sub>d</sub>) and still-birth (STI<sub>m</sub>, STI<sub>d</sub>) as well as maternal and paternal effects on nonreturn rates of 90 d (NR90<sub>m</sub>, NR90<sub>p</sub>). Furthermore, deregressed breeding values for functional herd life (FHL) and daughter yield deviation for somatic cell count (SCC) were investigated. Weighted multimarker regression analyses across families and permutation tests were applied for the detection of QTL and the calculation of statistical significance. A ten percent genomewise significant QTL was localized for DYS<sub>m</sub> on chromosome 8 and for SCC on chromosome 18. A further 24 putative QTL exceeding the 5% chromosomewise threshold were detected. On chromosomes 7, 8, 10, 18, and X/Y<sub>ps</sub>, coincidence of QTL for several traits was observed. Our results suggest that loci with influence on udder health may also contribute to genetic variance of longevity. Prior to implementation of these QTL in marker assisted selection programs for functional traits, information about direct and correlated effects of these QTL as well as fine mapping of their chromosomal positions is required.</p>}},
  author       = {{Kühn, Ch and Bennewitz, J. and Reinsch, N. and Xu, N. and Thomsen, H. and Looft, C. and Brockmann, G. A. and Schwerin, M. and Weimann, C. and Hiendleder, S. and Erhardt, G. and Medjugorac, I. and Förster, M. and Brenig, B. and Reinhardt, F. and Reents, R. and Russ, I. and Averdunk, G. and Blümel, J. and Kalm, E.}},
  issn         = {{0022-0302}},
  keywords     = {{Functional traits; Holstein cattle; Quantitative trait loci}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{1}},
  pages        = {{360--368}},
  publisher    = {{American Dairy Science Association}},
  series       = {{Journal of Dairy Science}},
  title        = {{Quantitative trait loci mapping of functional traits in the german Holstein cattle population}},
  url          = {{http://dx.doi.org/10.3168/jds.S0022-0302(03)73614-5}},
  doi          = {{10.3168/jds.S0022-0302(03)73614-5}},
  volume       = {{86}},
  year         = {{2003}},
}