A new brain tumour therapy combining bleomycin with in vivo electropermeabilization
Salford, Leif LU ; Persson, Bertil R LU
; Brun, Arne
LU
; Ceberg, Crister
LU
; Kongstad, Poul
LU
and Mir, Lluis M
(1993)
In Biochemical and Biophysical Research Communications
194(2).
p.938-943
- Abstract
- The potentials of in vivo electropermeabilization in combination with bleomycin in brain tumor treatment have been explored. In the brain of normal Fischer 344 rats, 2 electrodes were placed 5 mm apart. Electropermeabilization was performed with 8 to 12 exponential 400 V pulses with a time constant of 325 microseconds. Some animals were given bleomycin i.v., 1mg/kg b.w., 4 minutes before electric pulses delivery. No adverse effects were recorded during the observation of the animals during the following month. The effect of bleomycin and electropermeabilization upon tumour growth was studied in rats with glioma cells (RG2) implanted in the head of the right caudate nucleus. Treatment was given at different time intervals after the... (More)
- The potentials of in vivo electropermeabilization in combination with bleomycin in brain tumor treatment have been explored. In the brain of normal Fischer 344 rats, 2 electrodes were placed 5 mm apart. Electropermeabilization was performed with 8 to 12 exponential 400 V pulses with a time constant of 325 microseconds. Some animals were given bleomycin i.v., 1mg/kg b.w., 4 minutes before electric pulses delivery. No adverse effects were recorded during the observation of the animals during the following month. The effect of bleomycin and electropermeabilization upon tumour growth was studied in rats with glioma cells (RG2) implanted in the head of the right caudate nucleus. Treatment was given at different time intervals after the implantation of tumor cells and the effect upon survival was studied. Bleomycin alone did not prolong the survival of the animals. On the contrary, bleomycin plus electropermeabilization on the 10th, 11th or 12th day after inoculation increased the survival time to almost double that of untreated animals. We conclude that this treatment may be of value in brain tumour therapy. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1107450
- author
- Salford, Leif
LU
; Persson, Bertil R
LU
; Brun, Arne
LU
; Ceberg, Crister
LU
; Kongstad, Poul
LU
and Mir, Lluis M
- organization
- publishing date
- 1993
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Biochemical and Biophysical Research Communications
- volume
- 194
- issue
- 2
- pages
- 938 - 943
- publisher
- Elsevier
- external identifiers
-
- pmid:7688229
- scopus:0027163607
- ISSN
- 1090-2104
- DOI
- 10.1006/bbrc.1993.1911
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pathology, (Lund) (013030000), Neurosurgery (013026000), Radiation Physics, Lund (013034000)
- id
- ef573b65-e83c-485a-a809-1ada755355d6 (old id 1107450)
- date added to LUP
- 2016-04-01 16:23:47
- date last changed
- 2021-09-12 04:23:30
@article{ef573b65-e83c-485a-a809-1ada755355d6,
abstract = {{The potentials of in vivo electropermeabilization in combination with bleomycin in brain tumor treatment have been explored. In the brain of normal Fischer 344 rats, 2 electrodes were placed 5 mm apart. Electropermeabilization was performed with 8 to 12 exponential 400 V pulses with a time constant of 325 microseconds. Some animals were given bleomycin i.v., 1mg/kg b.w., 4 minutes before electric pulses delivery. No adverse effects were recorded during the observation of the animals during the following month. The effect of bleomycin and electropermeabilization upon tumour growth was studied in rats with glioma cells (RG2) implanted in the head of the right caudate nucleus. Treatment was given at different time intervals after the implantation of tumor cells and the effect upon survival was studied. Bleomycin alone did not prolong the survival of the animals. On the contrary, bleomycin plus electropermeabilization on the 10th, 11th or 12th day after inoculation increased the survival time to almost double that of untreated animals. We conclude that this treatment may be of value in brain tumour therapy.}},
author = {{Salford, Leif and Persson, Bertil R and Brun, Arne and Ceberg, Crister and Kongstad, Poul and Mir, Lluis M}},
issn = {{1090-2104}},
language = {{eng}},
number = {{2}},
pages = {{938--943}},
publisher = {{Elsevier}},
series = {{Biochemical and Biophysical Research Communications}},
title = {{A new brain tumour therapy combining bleomycin with in vivo electropermeabilization}},
url = {{http://dx.doi.org/10.1006/bbrc.1993.1911}},
doi = {{10.1006/bbrc.1993.1911}},
volume = {{194}},
year = {{1993}},
}