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Ischemic stroke rates decline in patients with atrial fibrillation as anticoagulants uptake improves : A Swedish cohort study

Mochalina, Natalia LU ; Isma, Nazim LU ; Svensson, Peter J. LU ; Själander, Anders; Carlsson, Maj LU ; Juhlin, Tord LU and Wieloch, Mattias LU (2017) In Thrombosis Research 158. p.44-48
Abstract

Introduction The impact of the increased anticoagulants uptake on incidence rate of ischemic stroke is largely unknown. We assessed time trends in rates of ischemic stroke in patients with incident atrial fibrillation (AF) diagnosed between 2011 and 2013. Materials and methods Population-based retrospective registry study of all 11,500 adults diagnosed with incident non-valvular atrial fibrillation in 2011–2013 in primary and secondary care and receiving oral anticoagulants (n = 4847), aspirin (n = 2850) or no treatment (n = 3766) in Skåne County, Sweden. The primary outcome was the rate of ischemic stroke within 365 days after AF diagnosis. Results and conclusion Cumulative incidence of ischemic stroke decreased from 2.87% (95%... (More)

Introduction The impact of the increased anticoagulants uptake on incidence rate of ischemic stroke is largely unknown. We assessed time trends in rates of ischemic stroke in patients with incident atrial fibrillation (AF) diagnosed between 2011 and 2013. Materials and methods Population-based retrospective registry study of all 11,500 adults diagnosed with incident non-valvular atrial fibrillation in 2011–2013 in primary and secondary care and receiving oral anticoagulants (n = 4847), aspirin (n = 2850) or no treatment (n = 3766) in Skåne County, Sweden. The primary outcome was the rate of ischemic stroke within 365 days after AF diagnosis. Results and conclusion Cumulative incidence of ischemic stroke decreased from 2.87% (95% confidence interval (CI) 2.37–3.45%) to 1.93% (95% CI 1.54–2.41%) while the uptake of oral anticoagulants increased from 36.6% to 48.4% between 2011 and 2013 (regression coefficient − 0.08; 95% CI, − 0.09 to − 0.07, p < 0.001). The increased uptake of oral anticoagulants in the community is associated with decreased incidence of ischemic stroke in AF patients.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Anticoagulants, Atrial fibrillation, Cohort studies, Incidence, Stroke
in
Thrombosis Research
volume
158
pages
5 pages
publisher
Elsevier
external identifiers
  • scopus:85027528754
  • pmid:28822239
ISSN
0049-3848
DOI
10.1016/j.thromres.2017.08.004
language
English
LU publication?
yes
id
f07a65e2-22bb-4bc2-9cfa-6ab23553c6de
date added to LUP
2017-09-01 13:09:36
date last changed
2017-09-01 13:09:36
@article{f07a65e2-22bb-4bc2-9cfa-6ab23553c6de,
  abstract     = {<p>Introduction The impact of the increased anticoagulants uptake on incidence rate of ischemic stroke is largely unknown. We assessed time trends in rates of ischemic stroke in patients with incident atrial fibrillation (AF) diagnosed between 2011 and 2013. Materials and methods Population-based retrospective registry study of all 11,500 adults diagnosed with incident non-valvular atrial fibrillation in 2011–2013 in primary and secondary care and receiving oral anticoagulants (n = 4847), aspirin (n = 2850) or no treatment (n = 3766) in Skåne County, Sweden. The primary outcome was the rate of ischemic stroke within 365 days after AF diagnosis. Results and conclusion Cumulative incidence of ischemic stroke decreased from 2.87% (95% confidence interval (CI) 2.37–3.45%) to 1.93% (95% CI 1.54–2.41%) while the uptake of oral anticoagulants increased from 36.6% to 48.4% between 2011 and 2013 (regression coefficient − 0.08; 95% CI, − 0.09 to − 0.07, p &lt; 0.001). The increased uptake of oral anticoagulants in the community is associated with decreased incidence of ischemic stroke in AF patients.</p>},
  author       = {Mochalina, Natalia and Isma, Nazim and Svensson, Peter J. and Själander, Anders and Carlsson, Maj and Juhlin, Tord and Wieloch, Mattias},
  issn         = {0049-3848},
  keyword      = {Anticoagulants,Atrial fibrillation,Cohort studies,Incidence,Stroke},
  language     = {eng},
  month        = {10},
  pages        = {44--48},
  publisher    = {Elsevier},
  series       = {Thrombosis Research},
  title        = {Ischemic stroke rates decline in patients with atrial fibrillation as anticoagulants uptake improves : A Swedish cohort study},
  url          = {http://dx.doi.org/10.1016/j.thromres.2017.08.004},
  volume       = {158},
  year         = {2017},
}