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Critical review on anti-obesity effects of phytochemicals through Wnt/β-catenin signaling pathway

Luo, Jinhai ; Yu, Zhiling ; Tovar, Juscelino LU ; Nilsson, Anne LU and Xu, Baojun (2022) In Pharmacological Research 184.
Abstract

Phytochemicals have been used as one of the sources for the development of anti-obesity drugs. Plants are rich in a variety of bioactive compounds including polyphenols, saponins and terpenes. Phytochemicals inhibit adipocyte differentiation by inhibiting the transcription and translation of adipogenesis transcription factors such as C/EBPα and PPARγ. It has been proved that phytochemicals inhibit the genes and proteins associated with adipogenesis and lipid accumulation by activating Wnt/β-catenin signaling pathway. The activation of Wnt/β-catenin signaling pathway by phytochemicals is multi-target regulation, including the regulation of pathway critical factor β-catenin and its target gene, the downregulation of destruction complex,... (More)

Phytochemicals have been used as one of the sources for the development of anti-obesity drugs. Plants are rich in a variety of bioactive compounds including polyphenols, saponins and terpenes. Phytochemicals inhibit adipocyte differentiation by inhibiting the transcription and translation of adipogenesis transcription factors such as C/EBPα and PPARγ. It has been proved that phytochemicals inhibit the genes and proteins associated with adipogenesis and lipid accumulation by activating Wnt/β-catenin signaling pathway. The activation of Wnt/β-catenin signaling pathway by phytochemicals is multi-target regulation, including the regulation of pathway critical factor β-catenin and its target gene, the downregulation of destruction complex, and the up-regulation of Wnt ligands, its cell surface receptor and Wnt antagonist. In this review, the literature on the anti-obesity effect of phytochemicals through Wnt/β-catenin signaling pathway is collected from Google Scholar, Scopus, PubMed, and Web of Science, and summarizes the regulation mechanism of phytochemicals in this pathway. As one of the alternative methods of weight loss drugs, Phytochemicals inhibit adipogenesis through Wnt/β-catenin signaling pathway. More progress in relevant fields may pose phytochemicals as the main source of anti-obesity treatment.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Phytochemicals, Anti-obesity, Wnt/β-catenin signaling pathway, C/EBPα, PPARγ, β-catenin
in
Pharmacological Research
volume
184
article number
106461
pages
12 pages
publisher
Academic Press
external identifiers
  • pmid:36152739
  • scopus:85138786196
  • pmid:36152739
ISSN
1096-1186
DOI
10.1016/j.phrs.2022.106461
language
English
LU publication?
yes
id
f132103d-1c7f-49a4-889a-530b89bc9591
date added to LUP
2022-09-30 15:46:25
date last changed
2024-02-18 09:00:33
@article{f132103d-1c7f-49a4-889a-530b89bc9591,
  abstract     = {{<p>Phytochemicals have been used as one of the sources for the development of anti-obesity drugs. Plants are rich in a variety of bioactive compounds including polyphenols, saponins and terpenes. Phytochemicals inhibit adipocyte differentiation by inhibiting the transcription and translation of adipogenesis transcription factors such as C/EBPα and PPARγ. It has been proved that phytochemicals inhibit the genes and proteins associated with adipogenesis and lipid accumulation by activating Wnt/β-catenin signaling pathway. The activation of Wnt/β-catenin signaling pathway by phytochemicals is multi-target regulation, including the regulation of pathway critical factor β-catenin and its target gene, the downregulation of destruction complex, and the up-regulation of Wnt ligands, its cell surface receptor and Wnt antagonist. In this review, the literature on the anti-obesity effect of phytochemicals through Wnt/β-catenin signaling pathway is collected from Google Scholar, Scopus, PubMed, and Web of Science, and summarizes the regulation mechanism of phytochemicals in this pathway. As one of the alternative methods of weight loss drugs, Phytochemicals inhibit adipogenesis through Wnt/β-catenin signaling pathway. More progress in relevant fields may pose phytochemicals as the main source of anti-obesity treatment.</p>}},
  author       = {{Luo, Jinhai and Yu, Zhiling and Tovar, Juscelino and Nilsson, Anne and Xu, Baojun}},
  issn         = {{1096-1186}},
  keywords     = {{Phytochemicals; Anti-obesity; Wnt/β-catenin signaling pathway; C/EBPα; PPARγ; β-catenin}},
  language     = {{eng}},
  month        = {{09}},
  publisher    = {{Academic Press}},
  series       = {{Pharmacological Research}},
  title        = {{Critical review on anti-obesity effects of phytochemicals through Wnt/β-catenin signaling pathway}},
  url          = {{http://dx.doi.org/10.1016/j.phrs.2022.106461}},
  doi          = {{10.1016/j.phrs.2022.106461}},
  volume       = {{184}},
  year         = {{2022}},
}