Monoamines' role in islet cell function and type 2 diabetes risk
Roberts, Fiona Louise LU ; Cataldo, Luis Rodrigo LU
and Fex, Malin
LU
(2023)
In Trends in Molecular Medicine
29(12).
p.1045-1058
- Abstract
The two monoamines serotonin and melatonin have recently been highlighted as potent regulators of islet hormone secretion and overall glucose homeostasis in the body. In fact, dysregulated signaling of both amines are implicated in β-cell dysfunction and development of type 2 diabetes mellitus (T2DM). Serotonin is a key player in β-cell physiology and plays a role in expansion of β-cell mass. Melatonin regulates circadian rhythm and nutrient metabolism and reduces insulin release in human and rodent islets in vitro. Herein, we focus on the role of serotonin and melatonin in islet physiology and the pathophysiology of T2DM. This includes effects on hormone secretion, receptor expression, genetic variants influencing β-cell function,... (More)
The two monoamines serotonin and melatonin have recently been highlighted as potent regulators of islet hormone secretion and overall glucose homeostasis in the body. In fact, dysregulated signaling of both amines are implicated in β-cell dysfunction and development of type 2 diabetes mellitus (T2DM). Serotonin is a key player in β-cell physiology and plays a role in expansion of β-cell mass. Melatonin regulates circadian rhythm and nutrient metabolism and reduces insulin release in human and rodent islets in vitro. Herein, we focus on the role of serotonin and melatonin in islet physiology and the pathophysiology of T2DM. This includes effects on hormone secretion, receptor expression, genetic variants influencing β-cell function, melatonin treatment, and compounds that alter serotonin availability and signaling.
(Less)
- author
- Roberts, Fiona Louise
LU
; Cataldo, Luis Rodrigo
LU
and Fex, Malin
LU
- organization
- publishing date
- 2023-12
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- G protein-coupled receptors, insulin secretion, type 2 diabetes mellitus, β-cell dysfunction
- in
- Trends in Molecular Medicine
- volume
- 29
- issue
- 12
- pages
- 14 pages
- publisher
- Elsevier
- external identifiers
-
- pmid:37722934
- scopus:85171279422
- ISSN
- 1471-4914
- DOI
- 10.1016/j.molmed.2023.08.009
- language
- English
- LU publication?
- yes
- id
- f6fbe867-2fcb-42dd-b5aa-1d36ffc38833
- date added to LUP
- 2023-12-28 09:25:52
- date last changed
- 2024-04-26 17:37:28
@article{f6fbe867-2fcb-42dd-b5aa-1d36ffc38833,
abstract = {{<p>The two monoamines serotonin and melatonin have recently been highlighted as potent regulators of islet hormone secretion and overall glucose homeostasis in the body. In fact, dysregulated signaling of both amines are implicated in β-cell dysfunction and development of type 2 diabetes mellitus (T2DM). Serotonin is a key player in β-cell physiology and plays a role in expansion of β-cell mass. Melatonin regulates circadian rhythm and nutrient metabolism and reduces insulin release in human and rodent islets in vitro. Herein, we focus on the role of serotonin and melatonin in islet physiology and the pathophysiology of T2DM. This includes effects on hormone secretion, receptor expression, genetic variants influencing β-cell function, melatonin treatment, and compounds that alter serotonin availability and signaling.</p>}},
author = {{Roberts, Fiona Louise and Cataldo, Luis Rodrigo and Fex, Malin}},
issn = {{1471-4914}},
keywords = {{G protein-coupled receptors; insulin secretion; type 2 diabetes mellitus; β-cell dysfunction}},
language = {{eng}},
number = {{12}},
pages = {{1045--1058}},
publisher = {{Elsevier}},
series = {{Trends in Molecular Medicine}},
title = {{Monoamines' role in islet cell function and type 2 diabetes risk}},
url = {{http://dx.doi.org/10.1016/j.molmed.2023.08.009}},
doi = {{10.1016/j.molmed.2023.08.009}},
volume = {{29}},
year = {{2023}},
}