C4b-binding protein (C4BP) activates B cells through the CD40 receptor
(2003) In Immunity 18(6). p.837-848- Abstract
- We demonstrate that the a. chain of human C4b binding protein (C4BP) binds directly to CD40 on human B cells at a site that differs from that used by CD40 ligand. C4BP induces proliferation, upregulation of CD54 and CD86 expression, and IL4-dependent IgE isotype switching in normal B cells but not in B cells from patients with CD40 or IKKgamma/NEMO deficiencies. Furthermore, C4BP colocalized with B cells in the germinal centers of human tonsils. These observations suggest that C4BP is an activating ligand for CD40 and establish a novel interface between complement and B cell activation.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/308125
- author
- organization
- publishing date
- 2003
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Immunity
- volume
- 18
- issue
- 6
- pages
- 837 - 848
- publisher
- Cell Press
- external identifiers
-
- pmid:12818164
- wos:000183767700013
- scopus:0038503986
- ISSN
- 1074-7613
- language
- English
- LU publication?
- yes
- id
- f8b64d40-ece0-4513-b242-003d3754cbaa (old id 308125)
- alternative location
- http://www.immunity.com/content/article/abstract?uid=PIIS1074761303001493
- date added to LUP
- 2016-04-01 11:51:16
- date last changed
- 2022-04-28 21:01:13
@article{f8b64d40-ece0-4513-b242-003d3754cbaa, abstract = {{We demonstrate that the a. chain of human C4b binding protein (C4BP) binds directly to CD40 on human B cells at a site that differs from that used by CD40 ligand. C4BP induces proliferation, upregulation of CD54 and CD86 expression, and IL4-dependent IgE isotype switching in normal B cells but not in B cells from patients with CD40 or IKKgamma/NEMO deficiencies. Furthermore, C4BP colocalized with B cells in the germinal centers of human tonsils. These observations suggest that C4BP is an activating ligand for CD40 and establish a novel interface between complement and B cell activation.}}, author = {{Brodeur, SR and Angelini, F and Bacharier, LB and Blom, Anna and Mizoguchi, E and Fujiwara, H and Plebani, A and Notarangelo, LD and Dahlbäck, Björn and Tsitsikov, E and Geha, RS}}, issn = {{1074-7613}}, language = {{eng}}, number = {{6}}, pages = {{837--848}}, publisher = {{Cell Press}}, series = {{Immunity}}, title = {{C4b-binding protein (C4BP) activates B cells through the CD40 receptor}}, url = {{http://www.immunity.com/content/article/abstract?uid=PIIS1074761303001493}}, volume = {{18}}, year = {{2003}}, }