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Tissue specificity in nerve regeneration

Lundborg, G LU ; Dahlin, L B LU ; Danielsen, N LU and Nachemson, A K (1986) In Scandinavian Journal of Plastic and Reconstructive Surgery 20(3). p.83-279
Abstract

In 1944 Weiss & Taylor presented experimental evidence against "neurotropism" in nerve regeneration. We used a silicone Y-chamber system to repeat some of those experiments. The proximal stump of transected rat sciatic nerve was introduced into the proximal inlet of the Y. One of the distal outlets was left empty, plugged or occupied by a tendon graft, the other outlet being occupied by a nerve graft. Analysis after 4 and 12 weeks showed in all cases a preferential or exclusive axonal growth towards the nerve piece. The results, indicating the existence of "tissue specificity", are contradictory to the results reported by Weiss & Taylor (30). The findings are discussed with respect to possible influence of humoral, cellular and... (More)

In 1944 Weiss & Taylor presented experimental evidence against "neurotropism" in nerve regeneration. We used a silicone Y-chamber system to repeat some of those experiments. The proximal stump of transected rat sciatic nerve was introduced into the proximal inlet of the Y. One of the distal outlets was left empty, plugged or occupied by a tendon graft, the other outlet being occupied by a nerve graft. Analysis after 4 and 12 weeks showed in all cases a preferential or exclusive axonal growth towards the nerve piece. The results, indicating the existence of "tissue specificity", are contradictory to the results reported by Weiss & Taylor (30). The findings are discussed with respect to possible influence of humoral, cellular and molecular factors associated with the distal nerve stump as well as the matrix, formed between both nerve segments.

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organization
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type
Contribution to journal
publication status
published
subject
keywords
Animals, Axons, Cytological Techniques, Nerve Regeneration, Organ Specificity, Rats, Sciatic Nerve, Tendons, Journal Article, Research Support, Non-U.S. Gov't
in
Scandinavian Journal of Plastic and Reconstructive Surgery
volume
20
issue
3
pages
83 - 279
publisher
Scandinavian University Press
external identifiers
  • scopus:0022878254
ISSN
0036-5556
language
English
LU publication?
yes
id
fd017e79-74ae-4fd3-8477-999fe36f3592
date added to LUP
2017-10-13 14:10:03
date last changed
2017-11-12 04:35:54
@article{fd017e79-74ae-4fd3-8477-999fe36f3592,
  abstract     = {<p>In 1944 Weiss &amp; Taylor presented experimental evidence against "neurotropism" in nerve regeneration. We used a silicone Y-chamber system to repeat some of those experiments. The proximal stump of transected rat sciatic nerve was introduced into the proximal inlet of the Y. One of the distal outlets was left empty, plugged or occupied by a tendon graft, the other outlet being occupied by a nerve graft. Analysis after 4 and 12 weeks showed in all cases a preferential or exclusive axonal growth towards the nerve piece. The results, indicating the existence of "tissue specificity", are contradictory to the results reported by Weiss &amp; Taylor (30). The findings are discussed with respect to possible influence of humoral, cellular and molecular factors associated with the distal nerve stump as well as the matrix, formed between both nerve segments.</p>},
  author       = {Lundborg, G and Dahlin, L B and Danielsen, N and Nachemson, A K},
  issn         = {0036-5556},
  keyword      = {Animals,Axons,Cytological Techniques,Nerve Regeneration,Organ Specificity,Rats,Sciatic Nerve,Tendons,Journal Article,Research Support, Non-U.S. Gov't},
  language     = {eng},
  number       = {3},
  pages        = {83--279},
  publisher    = {Scandinavian University Press},
  series       = {Scandinavian Journal of Plastic and Reconstructive Surgery},
  title        = {Tissue specificity in nerve regeneration},
  volume       = {20},
  year         = {1986},
}