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Human iPSC-Derived Hippocampal Spheroids : An Innovative Tool for Stratifying Alzheimer Disease Patient-Specific Cellular Phenotypes and Developing Therapies

Pomeshchik, Yuriy LU orcid ; Klementieva, Oxana LU orcid ; Gil, Jeovanis LU ; Martinsson, Isak LU ; Hansen, Marita Grønning LU ; de Vries, Tessa LU ; Sancho-Balsells, Anna LU ; Russ, Kaspar LU ; Savchenko, Ekaterina LU and Collin, Anna LU , et al. (2020) In Stem Cell Reports 15(1). p.256-273
Abstract

In this article, Roybon and colleagues developed a protocol to efficiently and rapidly generate hippocampus neurons from human induced pluripotent stem cells, which they used to model Alzheimer disease and develop a gene therapy approach to modulate the expression of genes involved in synaptic transmission.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Alzheimer disease, hippocampus, iPSC, NeuroD1, protein aggregation, proteomics, spheroids, transcriptomics, viral-mediated gene therapy
in
Stem Cell Reports
volume
15
issue
1
pages
18 pages
publisher
Cell Press
external identifiers
  • scopus:85087499545
  • pmid:32589876
ISSN
2213-6711
DOI
10.1016/j.stemcr.2020.06.001
language
English
LU publication?
yes
id
fd37f0d1-d452-414a-ba0c-38b395cdbffc
date added to LUP
2020-07-15 11:48:19
date last changed
2023-04-10 16:46:00
@article{fd37f0d1-d452-414a-ba0c-38b395cdbffc,
  abstract     = {{<p>In this article, Roybon and colleagues developed a protocol to efficiently and rapidly generate hippocampus neurons from human induced pluripotent stem cells, which they used to model Alzheimer disease and develop a gene therapy approach to modulate the expression of genes involved in synaptic transmission.</p>}},
  author       = {{Pomeshchik, Yuriy and Klementieva, Oxana and Gil, Jeovanis and Martinsson, Isak and Hansen, Marita Grønning and de Vries, Tessa and Sancho-Balsells, Anna and Russ, Kaspar and Savchenko, Ekaterina and Collin, Anna and Vaz, Ana Rita and Bagnoli, Silvia and Nacmias, Benedetta and Rampon, Claire and Sorbi, Sandro and Brites, Dora and Marko-Varga, György and Kokaia, Zaal and Rezeli, Melinda and Gouras, Gunnar K. and Roybon, Laurent}},
  issn         = {{2213-6711}},
  keywords     = {{Alzheimer disease; hippocampus; iPSC; NeuroD1; protein aggregation; proteomics; spheroids; transcriptomics; viral-mediated gene therapy}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{256--273}},
  publisher    = {{Cell Press}},
  series       = {{Stem Cell Reports}},
  title        = {{Human iPSC-Derived Hippocampal Spheroids : An Innovative Tool for Stratifying Alzheimer Disease Patient-Specific Cellular Phenotypes and Developing Therapies}},
  url          = {{http://dx.doi.org/10.1016/j.stemcr.2020.06.001}},
  doi          = {{10.1016/j.stemcr.2020.06.001}},
  volume       = {{15}},
  year         = {{2020}},
}