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- 2020
-
Shrunken pore syndrome and mortality : a cohort study of patients with measured GFR and known comorbidities
Åkesson, Anna LU
; Lindström, Veronica
LU
; Nyman, Ulf
LU
; Jonsson, Magnus
LU
; Abrahamson, Magnus
LU
; Christensson, Anders
LU
; Björk, Jonas
LU
and Grubb, Anders
LU
(2020)
In Scandinavian Journal of Clinical and Laboratory Investigation
80(5).
p.412-422
Mark
- Insufficient mixing of thawed serum samples leading to erroneous results–experience from a field study and use of a correction procedure
- Secreted cystatins decrease proliferation and enhance apoptosis of human leukemic cells
- 2019
-
Shrunken Pore Syndrome Is Associated With Increased Levels of Atherosclerosis-Promoting Proteins
Sällman Almén, Markus ; Björk, Jonas LU ; Nyman, Ulf LU ; Lindström, Veronica LU
; Jonsson, Magnus
LU
; Abrahamson, Magnus
LU
; Schiller Vestergren, AnnaLotta
; Lindhe, Örjan
; Franklin, Gary
and Christensson, Anders
LU
, et al.
(2019)
In Kidney International Reports
4(1).
p.67-79
Mark
- 2017
- Inhibition of lipopolysaccharide-induced osteoclast formation and bone resorption in vitro and in vivo by cysteine proteinase inhibitors
-
Estimating glomerular filtration rate (GFR) in children. The average between a cystatin C- and a creatinine-based equation improves estimation of GFR in both children and adults and enables diagnosing Shrunken Pore Syndrome
Leion, Felicia ; Hegbrant, Josefine ; den Bakker, Emil ; Jonsson, Magnus LU
; Abrahamson, Magnus
LU
; Nyman, Ulf
LU
; Björk, Jonas
LU
; Lindström, Veronica
LU
; Larsson, Anders
and Bökenkamp, Arend
, et al.
(2017)
In Scandinavian Journal of Clinical and Laboratory Investigation
77(5).
p.338-344
Mark
-
Low-level internalization of cystatin E/M affects legumain activity and migration of melanoma cells
Wallin, Hanna LU ; Apelqvist, Jenny LU ; Andersson, Freddi LU
; Ekström, Ulf
LU
and Abrahamson, Magnus
LU
(2017)
In Journal of Biological Chemistry
292(35).
p.14413-14424
Mark
- 2015
- Calcium Regulates the Activity and Structural Stability of Tpr, a Bacterial Calpain-like Peptidase.
- 2014
-
Fertility Defects in Mice Expressing the L68Q Variant of Human Cystatin C A ROLE FOR AMYLOID IN MALE INFERTILITY
Whelly, Sandra ; Serobian, Gaiane ; Borchardt, Clinton ; Powell, Jonathan ; Johnson, Seethal ; Håkansson, Katarina LU ; Lindström, Veronica LU
; Abrahamson, Magnus
LU
; Grubb, Anders
LU
and Cornwall, Gail A.
(2014)
In Journal of Biological Chemistry
289(11).
p.7718-7729
Mark
- 2013
- Cysteine proteinase inhibitors regulate human and mouse osteoclastogenesis by interfering with RANK signaling
-
Stabilization, Characterization and Selective Removal of Cystatin C Amyloid Oligomers.
Ranheimer Östner, Gustav ; Lindström, Veronica LU
; Hjort Christensen, Per
; Kozak, Maciej
; Abrahamson, Magnus
LU
and Grubb, Anders
LU
(2013)
In Journal of Biological Chemistry
288(23).
p.16438-16450
Mark
- Cleavage of IgG1 in gingival crevicular fluid is associated with the presence of Porphyromonas gingivalis
- Cystatin C properties crucial for uptake and inhibition of intracellular target enzymes.
- 2012
- Proteolysis of cystatin C by cathepsin D in the breast cancer microenvironment
- Intra- and extracellular regulation of activity and processing of legumain by cystatin E/M
- 2011
- Cleavage of IgG1 and IgG3 by gingipain K from Porphyromonas gingivalis may compromise host defense in progressive periodontitis.
- 2010
- Cystatin E/M suppresses legumain activity and invasion of human melanoma
-
Streptococcal inhibitor of complement-mediated lysis (SIC): an anti-inflammatory virulence determinant
Åkesson, Per LU ; Herwald, Heiko LU
; Rasmussen, Magnus
LU
; Håkansson, Katarina
LU
; Abrahamson, Magnus
LU
; Hasan, Ahmed A. K.
; Schmaier, Alvin H.
; Mueller-Ester, Werner
and Björck, Lars
LU
(2010)
In Microbiology
156.
p.3660-3668
Mark
- Cystatins - Extra- and Intracellular Cysteine Protease Inhibitors: High-level Secretion and Uptake of Cystatin C in Human Neuroblastoma Cells.
- Phenotype associated with mutation in the recently identified autosomal dominant retinitis pigmentosa KLHL7 gene.
- 2009
- Mutations in a BTB-Kelch Protein, KLHL7, Cause Autosomal-Dominant Retinitis Pigmentosa
- Crystal structure of the parasite inhibitor chagasin in complex with papain allows identification of structural requirements for broad reactivity and specificity determinants for target proteases
- Cystatin C is downregulated in prostate cancer and modulates invasion of prostate cancer cells via MAPK/Erk and androgen receptor pathways.
- Macrophage Responses to Interferon-gamma are Dependent on Cystatin C Levels.
- Physiopathology of retinal degeneration in rd1 mouse model of retinitis pigmentosa : TGF-Β1, proteinases and oxidative stress mechanisms
- 2008
- Displacement of the occluding loop by the parasite protein, chagasin, results in efficient inhibition of human cathepsin
- Internalization of cystatin C in human cell lines.
- rd1 Mouse retina shows an imbalance in the activity of cysteine protease cathepsins and their endogenous inhibitor cystatin C.
- The Human Protease Inhibitor Cystatin C Is an Activating Cofactor for the Streptococcal Cysteine Protease IdeS.
- 2007
- Cystatin C binds serum amyloid A, downregulating its cytokine-generating properties
- Low glutathione peroxidase in rdl mouse retina increases oxidative stress and proteases
- The structure of chagasin in complex with a cysteine protease clarifies the binding mode and evolution of an inhibitor family
-
Down-regulation of human extracellular cysteine protease inhibitors by the secreted staphylococcal cysteine proteases, staphopain A and B.
Vincents, Bjarne LU ; Önnerfjord, Patrik LU
; Gruca, Milosz
; Potempa, Jan
and Abrahamson, Magnus
LU
(2007)
In Biological Chemistry
388(4).
p.437-446
Mark
- The cysteine protease inhibitors cystatins inhibit herpes simplex virus type 1-induced apoptosis and virus yield in HEp-2 cells
- Crystal Structure of the Parasite Protease Inhibitor Chagasin in Complex with a Host Target Cysteine Protease.
- 2006
- rd1 Mouse Retina Shows Imbalance in Cellular Distribution and Levels of TIMP-1/MMP-9, TIMP-2/MMP-2 and Sulfated Glycosaminoglycans.
- Aberrant expression of cystatin C in prostate cancer is associated with neuroendocrine differentiation.
- Cystatins in non-small cell lung cancer: Tissue levels, localization and relation to prognosis
- Human cystatins - similarities, diversity and classification
- Structural and protease inhibitory features of cystatins
- 2005
- In search of selective inhibitors of cysteine protease, cathepsin K
- Cystatin C modulates neurodegeneration and neurogenesis following status epilepticus in mouse
- Crystal structure of human cystatin D, a cysteine peptidase inhibitor with restricted inhibition profile.
-
Clinical phenotype in a Swedish family with a mutation in the IMPDH1 gene.
Schatz, Patrik LU
; Ponjavic, Vesna
LU
; Andréasson, Sten
LU
; McGee, Terri L
; Dryja, Thaddeus P
and Abrahamson, Magnus
LU
(2005)
In Ophthalmic Genetics
26(3).
p.24-119
Mark
- Cystatin C uptake in the eye.
- Juvenile X-linked retinoschisis with normal scotopic b-wave in the electroretinogram at an early stage of the disease.
-
Different cysteine proteinases involved in bone resorption and osteoclast formation
Brage, M ; Abrahamson, Magnus LU ; Lindström, Veronica LU
; Grubb, Anders
LU
and Lerner, U H
(2005)
In Calcified Tissue International
76(6).
p.439-447
Mark
- 3D domain-swapped human cystatin c with amyloidlike intermolecular beta-sheets
- Inhibitory properties of cystatin F and its localization in U937 promonocyte cells
- Novel azapeptide inhibitors of cathepsins B and K. Structural background to increased specificity for cathepsin B
- 2004
- Enzymatic characterization of the streptococcal endopeptidase, IdeS, reveals that it is a cysteine protease with strict specificity for igg cleavage due to exosite binding.
- Engineered multidomain cysteine protease inhibitors yield resistance against western flower thrips (Franklinielia occidentalis) in greenhouse trials
- Specific cysteine protease inhibitors act as deterrents of western flower thrips, Frankliniella occidentalis (Pergande), in transgenic potato
- Glutathione S-transferase µ(GST) modifies activities of proteases and levels of cystatin C secreted by mouse retinal explants
- Domain swapping in N-truncated human cystatin C
- Osteoclastogenesis is decreased by cysteine proteinase inhibitors
- Cystatin C is highly expressed in the human male reproductive system.
- Cystatin C in the anterior segment of rat and mouse eyes.
- Cysteine proteinases in osteoclast function and recruitment
- 2003
- Cystatins C, E/M and F in human pleural fluids of patients with neoplastic and inflammatory lung disorders
- Cystatins.
-
Macular appearance by means of OCT and electrophysiology in members of two families with different mutations in RDS (the peripherin/RDS gene).
Schatz, Patrik LU
; Abrahamson, Magnus
LU
; Eksandh, Louise
LU
; Ponjavic, Vesna
LU
and Andréasson, Sten
LU
(2003)
In Acta Ophthalmologica Scandinavica
81(5).
p.500-507
Mark
- Cathepsin B in the rat eye.
- Growth of the postnatal rat retina in vitro: Quantitative RT-PCR analyses of mRNA expression for photoreceptor proteins
- 2002
- Physico-chemical properties of the N-terminally truncated L68Q cystatin C found in amyloid deposits of brain haemorrhage patients.
- Regulated expression and intracellular localization of cystatin F in human U937 cells.
- Azapeptides structurally based upon inhibitory sites of cystatins as potent and selective inhibitors of cysteine proteases
- Structure-based design and synthesis of cathepsin K inhibitors
- 2001
- Lysosomal protease pathways to apoptosis - Cleavage of Bid, not pro-caspases, is the most likely route
- Identification, characterization and localization of chagasin, a tight-binding cysteine protease inhibitor in Trypanosoma cruzi
- Peptidyl diazomethylketones as cysteine protease inhibitors structurally based upon the inhibitory centers of cystatins
- Identification and localization of retinal cystatin C
- Electrophysiologic findings in two young patients with Bothnia dystrophy and a mutation in the RLBP1 gene
- Peptidyl aldehydes based on N-terminal binding fragments of cystatins as thioprotease inhibitors
- Different clinical expressions in two families with Stargardt's macular dystrophy (STGD1)
- Human cystatin C, an amyloidogenic protein, dimerizes through three-dimensional domain swapping
- 2000
- Functional effects of the inhibition of the cysteine protease activity of the major house dust mite allergen Der p 1 by a novel peptide-based inhibitor
- Expression of an LDL receptor allele with two different mutations (E256K and I402T)
- A peptidyl derivative structurally based on the inhibitory center of cystatin C inhibits bone resorption in vitro
- Cystatin inhibition of cathepsin B requires dislocation of the proteinase occluding loop. Demonstration by release of loop anchoring through mutation of His110
- 1999
- An individual with a healthy phenotype in spite of a pathogenic LDL receptor mutation (C240F)
- Inhibition of mammalian legumain by some cystatins is due to a novel second reactive site
- Modulation of invasive properties of murine squamous carcinoma cells by heterologous expression of cathepsin B and cystatin C
- Digenic inheritance of a ROM1 gene mutation with a peripherin/RDS or rhodopsin mutation in families with retinitis pigmentosa
- Decreased metastatic spread in mice homozygous for a null allele of the cystatin C protease inhibitor gene
- Expression of a selenomethionine derivative and preliminary crystallographic studies of human cystatin C
- 1998
- Mutations in the low-density lipoprotein receptor gene in Swedish familial hypercholesterolaemia patients: clinical expression and treatment response
- Cystatin F is a glycosylated human low molecular weight cysteine proteinase inhibitor
- Two stable unfolding intermediates of the disease-causing L68Q variant of human cystatin C
- Structural basis for different inhibitory specificities of human cystatins C and D
- Intracellular accumulation of the amyloidogenic L68Q variant of cystatin C in NIH/3T3 cells
- A Swedish family with a mutation in the peripherin/RDS gene (Arg-172-Trp) associated with a progressive retinal degeneration
- Clinical expression of X-linked retinitis pigmentosa in a Swedish family with the RP2 genotype
- Detection of alterations in all three exons of the peripherin/RDS gene in Swedish patients with retinitis pigmentosa using an efficient DGGE system
- Amino acid substitutions in the N-terminal segment of cystatin C create selective inhibitors of lysosomal cysteine proteinases
- Phenotypic expression of autosomal dominant retinitis pigmentosa in a Swedish family expressing a Phe-211-Leu variant of peripherin/RDS
- Two-step mechanism of inhibition of cathepsin B by cystatin C, due to the inhibitor displacing the occluding loop of the enzyme
-
A 50-year perspective of a family with chromosome 14-linked Alzheimer’s disease
Gustafson, Lars LU ; Brun, Arne LU ; Hagnell, Olle ; Nilsson, Karin ; Stensmyr, Maria ; Öhlin, Ann-Kristin LU ; Abrahamson, Magnus LU and Englund, Elisabet LU
(1998)
In Human Genetics
102(3).
p.253-257
Mark
- Phenotype in a Swedish family with X-linked retinitis pigmentosa caused by a novel splice defect in the RPGR gene
- 1997
- Analysis of the RPGR gene in 11 pedigrees with the retinitis pigmentosa type 3 genotype: Paucity of mutations in the coding region, but splice defects in two families
- Cathepsin B and cysteine proteinase inhibitors in human lung cancer cell lines
- Apolipoprotein E genotyping in Alzheimer’s disease and frontotemporal dementia
- Cystatin E is a novel human cysteine proteinase inhibitor with structural resemblance to family 2 cystatins
- A mild phenotype of autosomal dominant retinitis pigmentosa is associated with the rhodopsin mutation Pro-267–Leu
- Modification of cystatin C activity by bacterial proteinases and neutrophil elastase in periodontitis
- Expression of cysteine proteinase inhibitors stefin A, stefin B, and cystatin C in human lung tumor tissue
- Phenotypes in three Swedish families with X-linked retinitis pigmentosa caused by different mutations in the RPGR gene
- Affinity purification and elimination of methionine oxidation in recombinant human cystatin C
- NMR structural studies of human cystatin C dimers and monomers
- Autosomal dominant retinitis pigmentosa with a rhodopsin mutation (Arg-135–Trp): Disease phenotype in a Swedish family
- 1996
- Folding related dimerization of human cystatin C
-
Mouse and rat cystatin C: Escherichia coli production, characterization and tissue distribution
Håkansson, Katarina LU ; Huh, Changgoo ; Grubb, Anders LU ; Karlsson, Stefan LU
and Abrahamson, Magnus
LU
(1996)
In Comparative Biochemistry and Physiology - Part B: Biochemistry & Molecular Biology
114(3).
p.303-311
Mark
- Lack of relationship between insertion/deletion polymorphism in the angiotensin converting enzyme gene and severe retinopathy in insulin-dependent diabetes mellitus
- The importance of the second hairpin loop of cystatin C for proteinase binding. Characterization of the interaction of Trp-106 variants of the inhibitor with cysteine proteinases
- Molecular basis for amyloidosis related to hereditary brain hemorrhage
- 1995
- Structural basis for the biological specificity of cystatin C. Identification of leucine 9 in the N-terminal binding region as a selectivity-conferring residue in the inhibition of mammalian cysteine peptidases
- Phenotype variation within a choroideremia family lacking the entire CHM gene
- Probing the functional role of the N-terminal region of cystatins by equilibrium and kinetic studies of the binding of Gly-11 variants of recombinant human cystatin C to target proteinases
- Synthesis and secretion of procathepsin B and cystatin C by human bronchial epithelial cells in vitro: modulation of cathepsin B activity by neutrophil elastase
- Antigenicity of cystatin-binding proteins from parasitic protozoan. Detection by a proteinase inhibitor based capture immunoassay (PINC-ELISA)
- Structural organization, expression and chromosomal mapping of the mouse cystatin C gene (Cst3)
- An efficient screening procedure detecting six novel mutations in the LDL receptor gene in Swedish children with hypercholesterolemia
- 1994
- Evidence for the interaction of valine-10 in cystatin C with the S2 subsite of cathepsin B
- Secretion of cathepsin B and tumor invasion
- Structural and functional characterization of two allelic variants of human cystatin D sharing a characteristic inhibition spectrum against mammalian cysteine proteinases
- Increased body temperature accelerates aggregation of the (Leu-68–>Gln) mutant cystatin C, the amyloid-forming protein in hereditary cystatin C amyloid angiopathy
- Latency of cathepsin B secreted by human colon carcinoma cells is not linked to secretion of cystatin C and is relieved by neutrophil elastase
- Differential changes in the association and dissociation rate constants for binding of cystatins to target proteinases occurring on N-terminal truncation of the inhibitors indicate that the interaction mechanism varies with different enzymes
- Cystatins
- 1993
- Human cystatin D: cDNA cloning, characterization of the E. coli expressed inhibitor, and identification of the native protein in saliva
- Cystatin C (CST3), the candidate gene for hereditary cystatin C amyloid angiopathy (HCCAA), and other members of the cystatin gene family are clustered on chromosome 20p11.2
- An Ala/Thr variation in the coding region of the human cystatin C gene (CST3) detected as a Sst II polymorphism
- Cystatins - Protein inhibitors of papain-like cysteine proteinases
- Importance of the evolutionarily conserved glycine residue in the N-terminal region of cystatin C (Gly-11) for cysteine endopeptidase inhibition
- Localization of the human cystatin D gene (CST5) to chromosome 20p11.21 by in situ hybridization
- A sequence variation in the human cystatin D gene resulting in an amino acid (Cys/Arg) polymorphism at the protein level
- 1992
- Cystatin C based peptidyl diazomethanes as cysteine proteinase inhibitors: Influence of the peptidyl chain length
- A novel mutation in the β-protein coding region of the amyloid β-protein precursor (APP) gene
- PCR assay for a polymorphic Dde I site in the promoter region of the human cystatin C gene (CST3)
- Demonstration of sequence variations in the promoter region of the human cystatin C gene
- Interaction of recombinant human cystatin C with the cysteine proteinases papain and actinidin
- A six generation family with autosomal dominant retinitis pigmentosa and a rhodopsin gene mutation (arginine-135–leucine)
- Hereditary cystatin C amyloid angiopathy: Identification of the disease causing mutation and specific diagnosis by polymerase chain reaction based analysis
- Cystatin C and cathepsin B in human colon carcinoma: Expression in cell lines and matrix degradation
- 1991
- Structure and expression of the gene encoding cystatin D, a novel human cysteine proteinase inhibitor
-
Human monoclonal antibodies with different fine-specificity for digoxin derivatives: Cloning of heavy and light chain variable region sequences
Danielsson, L ; Furebring, Christina LU ; Ohlin, Mats LU
; Hultman, L
; Abrahamson, Magnus
LU
; Carlsson, Roland
LU
and Borrebaeck, Carl
LU
(1991)
In Immunology
74(1).
p.50-54
Mark
- Sst II polymorphic sites in the promoter region of the human cystatin C gene
- Determination of allotypes G1m(f) and G1m(z) at the genomic level by subclass specific amplification of DNA and use of allele specific probes
- Human cystatin C: Role of the N-terminal segment in the inhibition of human cysteine proteinases and in its inactivation by leucocyte elastase
- Human sputum cathepsin B degrades proteoglycan, is inhibited by a2-macroglobulin and modulated by neutrophil elastase cleavage of cathepsin B precursor and cystatin C
- Regulation of cystatin C activity by serine proteinases
- 1990
- Three RFLP's at the 3' end of the cystatin C gene, the disease gene in hereditary cystatin C amyloid angiopathy (HCCAA) in Iceland
- Interactions of papaya proteinase IV with inhibitors
- Cystatin C mutation causing amyloid angiopathy and brain hemorrhage
- Levels of neutrophil elastase and cathepsin B activities, and cystatins in human sputum: relationship to inflammation
- Structure and expression of the human cystatin C gene
- Assignment of allotypes G1m(a+) and G1m(a-) at the genomic level by polymerase chain reaction analysis
- The aminoterminal portion of cerebrospinal fluid cystatin C in hereditary cystatin C amyloid angiopathy is not truncated. Direct sequence analysis from agarose gel electropherograms
- Synthesis of cysteine proteinase inhibitors structurally based on the proteinase interacting N-terminal region of human cystatin C
- Human cystatin C. An overview of a cysteine proteinase inhibitor in health and disease
- Secreted active forms of cathepsin B
- 1989
- Bacterial growth inhibited by a synthetic inhibitor based upon the structure of a human proteinase inhibitor
- High-level expression of active human cystatin C in Escherichia coli
- Study of restriction fragment length polymorphism in the cystatin C gene of elderly patients with dementia and aged Down's syndrome patients
- The human cystatin C gene (CST3), mutated in hereditary cystatin C amyloid angiopathy, is located on chromosome 20
- Polymemse chain reaction using mixed primers. Cloning of human monoclonal antibody variable region genes from single hybridoma cells
- Mutation in the cystatin C gene causes hereditary brain hemorrhage
- Rapid cloning of rearranged immunoglobulin genes from human hybridoma cells using mixed primers and the polymerase chain reaction
- An efficient E. coli expression system for human cystatin C: Production and characterization of the native and N-terminally Ala-Met-Glu-Ala-Glu-extended inhibitor
- 1988
- Mutation in cystatin C gene causes hereditary brain haemorrhage
- Efficient production of native, biologically active human cystatin C by Escherichia coli
- Human cysteine proteinase inhibitors. Isolation, physiological importance, inhibitory mechanism, gene structure and relation to hereditary cerebral hemorrhage
- Production, characterization and use of monoclonal antibodies against the major extracellular human cysteine proteinase inhibitors cystatin C and kininogen
- Studies on the cystatin C gene in patients with hereditary cystatin C amyloid angiopathy (HCCAA) with cerebral haemorrhage
- An isolate of families with hereditary cystatin C amyloid angiopathy and cerebral haemorrhage in the south of Iceland
- 1987
- Identification of the probable inhibitory reactive sites of the cysteine proteinase inhibitors human cystatin C and chicken cystatin
- Molecular cloning and sequence analysis of cDNA coding for the precursor of the human cysteine proteinase inhibitor cystatin C
- 1986
- Isolation of six cysteine proteinase inhibitors from human urine. Their physicochemical and enzyme kinetic properties and concentrations in biological fluids
- Human low-Mr kininogen contains three copies of a cystatin sequence that are divergent in structure and in inhibitory activity for cysteine proteinases.
- The biochemistry of the action of chymopapain in relief of sciatica
- Cystatin-like domains of LMW-kininogen, and speculations on the evolution of cystatins