Reduction in cardiometabolic risk factors by a multifunctional diet is mediated via several branches of metabolism as evidenced by nontargeted metabolite profiling approach
(2017) In Molecular Nutrition and Food Research 61(2).- Abstract
Scope: Multifunctional diet (MFD), a diet based on multiple functional concepts and ingredients with anti-inflammatory activity, was previously shown to improve different cardiometabolic risk-associated markers in healthy subjects. Here, we assessed the impact of MFD on plasma metabolome and explored associations of the differential metabolites with clinical parameters, searching for metabolic determinants related to the effects of MFD. Methods and results: Forty-four overweight healthy volunteers completed a randomized crossover intervention comparing MFD with a control diet devoid of the active components of MFD. Fasting plasma samples were analyzed with nontargeted metabolite profiling at baseline and at the end (4 wk) of each diet... (More)
Scope: Multifunctional diet (MFD), a diet based on multiple functional concepts and ingredients with anti-inflammatory activity, was previously shown to improve different cardiometabolic risk-associated markers in healthy subjects. Here, we assessed the impact of MFD on plasma metabolome and explored associations of the differential metabolites with clinical parameters, searching for metabolic determinants related to the effects of MFD. Methods and results: Forty-four overweight healthy volunteers completed a randomized crossover intervention comparing MFD with a control diet devoid of the active components of MFD. Fasting plasma samples were analyzed with nontargeted metabolite profiling at baseline and at the end (4 wk) of each diet period by LC coupled to quadrupole-TOF-MS system, revealing a vast impact of MFD on metabolic homeostasis. Main metabolite classes affected included acylcarnitines, furan fatty acids, phospholipids (plasmalogens, phosphatidylcholines, phosphatidylethanolamines), and various low-molecular weight products from the bioactivity of gut microbiota. Circulating levels of several of these metabolites correlated with changes in clinical blood lipid biomarkers. Conclusions: The metabolomics approach revealed that consumption of MFD affected different areas of metabolism, highlighting the impact of a healthy diet on plasma metabolome. This seems linked to reduced cardiometabolic risk and provides mechanistic insight into the effects of MFD.
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- author
- Tovar, Juscelino LU ; de Mello, Vanessa ; Nilsson, Anne LU ; Johansson, Maria LU ; Paananen, Jussi ; Lehtonen, Marko ; Hanhineva, Kati and Björck, Inger LU
- organization
- publishing date
- 2017-02-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Cardiometabolic diseases, Dietary prevention, Functional foods, Metabolic syndrome, Plasma metabolomics
- in
- Molecular Nutrition and Food Research
- volume
- 61
- issue
- 2
- article number
- 1600552
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- scopus:84999779286
- pmid:27670644
- wos:000394840800019
- ISSN
- 1613-4125
- DOI
- 10.1002/mnfr.201600552
- project
- ANTIDIABETIC FOOD CENTRE
- language
- English
- LU publication?
- yes
- id
- 06ea6345-49b7-4da7-b930-89139c94d77f
- date added to LUP
- 2017-02-20 10:50:20
- date last changed
- 2024-08-18 16:19:12
@article{06ea6345-49b7-4da7-b930-89139c94d77f, abstract = {{<p>Scope: Multifunctional diet (MFD), a diet based on multiple functional concepts and ingredients with anti-inflammatory activity, was previously shown to improve different cardiometabolic risk-associated markers in healthy subjects. Here, we assessed the impact of MFD on plasma metabolome and explored associations of the differential metabolites with clinical parameters, searching for metabolic determinants related to the effects of MFD. Methods and results: Forty-four overweight healthy volunteers completed a randomized crossover intervention comparing MFD with a control diet devoid of the active components of MFD. Fasting plasma samples were analyzed with nontargeted metabolite profiling at baseline and at the end (4 wk) of each diet period by LC coupled to quadrupole-TOF-MS system, revealing a vast impact of MFD on metabolic homeostasis. Main metabolite classes affected included acylcarnitines, furan fatty acids, phospholipids (plasmalogens, phosphatidylcholines, phosphatidylethanolamines), and various low-molecular weight products from the bioactivity of gut microbiota. Circulating levels of several of these metabolites correlated with changes in clinical blood lipid biomarkers. Conclusions: The metabolomics approach revealed that consumption of MFD affected different areas of metabolism, highlighting the impact of a healthy diet on plasma metabolome. This seems linked to reduced cardiometabolic risk and provides mechanistic insight into the effects of MFD.</p>}}, author = {{Tovar, Juscelino and de Mello, Vanessa and Nilsson, Anne and Johansson, Maria and Paananen, Jussi and Lehtonen, Marko and Hanhineva, Kati and Björck, Inger}}, issn = {{1613-4125}}, keywords = {{Cardiometabolic diseases; Dietary prevention; Functional foods; Metabolic syndrome; Plasma metabolomics}}, language = {{eng}}, month = {{02}}, number = {{2}}, publisher = {{John Wiley & Sons Inc.}}, series = {{Molecular Nutrition and Food Research}}, title = {{Reduction in cardiometabolic risk factors by a multifunctional diet is mediated via several branches of metabolism as evidenced by nontargeted metabolite profiling approach}}, url = {{http://dx.doi.org/10.1002/mnfr.201600552}}, doi = {{10.1002/mnfr.201600552}}, volume = {{61}}, year = {{2017}}, }