Neural stem and progenitor cells retain their potential for proliferation and differentiation into functional neurons despite lower number in aged brain.

Ahlenius, Henrik; Visan, Violeta; Kokaia, Merab; Lindvall, Olle; Kokaia, Zaal

Neural stem and progenitor cells retain their potential for proliferation and differentiation into functional neurons despite lower number in aged brain.

Mark

Ahlenius, Henrik ^LU ; Visan, Violeta ^LU ; Kokaia, Merab ^LU ; Lindvall, Olle ^LU and Kokaia, Zaal ^LU

(2009) In The Journal of Neuroscience : the official journal of the Society for Neuroscience 29(14). p.4408-4419

Abstract: Neurogenesis in the subventricular zone (SVZ), which gives rise to new neurons in the olfactory bulb, continues throughout life but declines with increasing age. Little is known about how aging affects the intrinsic properties of the neural stem and progenitor cells (NSCs) in SVZ and the functional characteristics of their neuronal progeny. Here, we have compared the properties of NSCs isolated from embryonic lateral ganglionic eminence and adult and aged SVZ in mice using in vivo and in vitro systems, analyzed their gene expression profile, and studied their electrophysiological characteristics before and after differentiation into neurons. We show a loss of NSCs in SVZ from aged mice accompanied by reduced expression of genes for NSC... (More); Neurogenesis in the subventricular zone (SVZ), which gives rise to new neurons in the olfactory bulb, continues throughout life but declines with increasing age. Little is known about how aging affects the intrinsic properties of the neural stem and progenitor cells (NSCs) in SVZ and the functional characteristics of their neuronal progeny. Here, we have compared the properties of NSCs isolated from embryonic lateral ganglionic eminence and adult and aged SVZ in mice using in vivo and in vitro systems, analyzed their gene expression profile, and studied their electrophysiological characteristics before and after differentiation into neurons. We show a loss of NSCs in SVZ from aged mice accompanied by reduced expression of genes for NSC markers, developmentally important transcription factors, and neurogenic factors. However, when isolated in vitro, the NSCs from SVZ of aged animals have capacity for proliferation and multilineage differentiation, including production of functional neurons, similar to that of NSCs in adult mice, albeit with lower efficacy. These properties are of major importance when considering therapeutic applications of neuronal replacement from endogenous NSCs in the injured, aged brain. (Less)

Please use this url to cite or link to this publication: https://lup.lub.lu.se/record/1392241

author

Ahlenius, Henrik ^LU ; Visan, Violeta ^LU ; Kokaia, Merab ^LU ; Lindvall, Olle ^LU and Kokaia, Zaal ^LU

organization

Neurology, Lund

publishing date

2009

type

Contribution to journal

publication status

published

subject

Neurosciences

in

The Journal of Neuroscience : the official journal of the Society for Neuroscience

volume

29

issue

14

pages

4408 - 4419

publisher

Society for Neuroscience

external identifiers

wos:000265009600009
pmid:19357268
scopus:65549125564
pmid:19357268

ISSN

1529-2401

DOI

10.1523/JNEUROSCI.6003-08.2009

language

English

LU publication?

yes

id

e73dc994-458a-43e0-a7b1-a3003e42476b (old id 1392241)

alternative location

http://www.ncbi.nlm.nih.gov/pubmed/19357268?dopt=Abstract

date added to LUP

2016-04-04 09:15:24

date last changed

2023-09-19 21:12:39

@article{e73dc994-458a-43e0-a7b1-a3003e42476b,
  abstract     = {{Neurogenesis in the subventricular zone (SVZ), which gives rise to new neurons in the olfactory bulb, continues throughout life but declines with increasing age. Little is known about how aging affects the intrinsic properties of the neural stem and progenitor cells (NSCs) in SVZ and the functional characteristics of their neuronal progeny. Here, we have compared the properties of NSCs isolated from embryonic lateral ganglionic eminence and adult and aged SVZ in mice using in vivo and in vitro systems, analyzed their gene expression profile, and studied their electrophysiological characteristics before and after differentiation into neurons. We show a loss of NSCs in SVZ from aged mice accompanied by reduced expression of genes for NSC markers, developmentally important transcription factors, and neurogenic factors. However, when isolated in vitro, the NSCs from SVZ of aged animals have capacity for proliferation and multilineage differentiation, including production of functional neurons, similar to that of NSCs in adult mice, albeit with lower efficacy. These properties are of major importance when considering therapeutic applications of neuronal replacement from endogenous NSCs in the injured, aged brain.}},
  author       = {{Ahlenius, Henrik and Visan, Violeta and Kokaia, Merab and Lindvall, Olle and Kokaia, Zaal}},
  issn         = {{1529-2401}},
  language     = {{eng}},
  number       = {{14}},
  pages        = {{4408--4419}},
  publisher    = {{Society for Neuroscience}},
  series       = {{The Journal of Neuroscience : the official journal of the Society for Neuroscience}},
  title        = {{Neural stem and progenitor cells retain their potential for proliferation and differentiation into functional neurons despite lower number in aged brain.}},
  url          = {{https://lup.lub.lu.se/search/files/5274579/1399212.pdf}},
  doi          = {{10.1523/JNEUROSCI.6003-08.2009}},
  volume       = {{29}},
  year         = {{2009}},
}

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Neural stem and progenitor cells retain their potential for proliferation and differentiation into functional neurons despite lower number in aged brain.