Combinations of cereal β-glucans and probiotics can enhance the anti-inflammatory activity on host cells by a synergistic effect
(2016) In Journal of Functional Foods 23. p.12-23- Abstract
The influence of oat and barley β-glucans on some features of diverse probiotic strains was investigated. Neither barley nor oat β-glucans supported the growth of any of the investigated strains when used as the sole carbon source in fermentation media. No protective effect by β-glucans was observed on bacterial survival to in vitro simulation of the human digestive tract. Moreover, the presence of β-glucans did not enhance the ability of probiotic bacteria to adhere on human intestinal cells. The immunomodulatory activities of probiotics, β-glucans, and their combinations were studied and compared in vitro by transcriptional analysis of immune-related genes on LPS-stimulated THP-1 macrophages. Immune modulating properties were... (More)
The influence of oat and barley β-glucans on some features of diverse probiotic strains was investigated. Neither barley nor oat β-glucans supported the growth of any of the investigated strains when used as the sole carbon source in fermentation media. No protective effect by β-glucans was observed on bacterial survival to in vitro simulation of the human digestive tract. Moreover, the presence of β-glucans did not enhance the ability of probiotic bacteria to adhere on human intestinal cells. The immunomodulatory activities of probiotics, β-glucans, and their combinations were studied and compared in vitro by transcriptional analysis of immune-related genes on LPS-stimulated THP-1 macrophages. Immune modulating properties were evidenced. In particular, mixtures of probiotic microorganisms and barley β-glucans exhibited synergistic effects in modulating the transcriptional level of several immune-related genes, leading to an overall enhanced anti-inflammatory effect. Together, these findings suggest a promising application of probiotic bacteria and β-glucans in the preparation of dietary mixtures presenting health-promoting features such as immunomodulatory properties.
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- author
- Arena, Mattia Pia ; Russo, Pasquale ; Capozzi, Vittorio ; Rascón, Ana LU ; Felis, Giovanna E. ; Spano, Giuseppe and Fiocco, Daniela
- organization
- publishing date
- 2016-05-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Beta Glucan (PubChem CID: 9202437), Immune system, Prebiotics, Probiotics, Relative gene expression, Synbiotics, β-glucan
- in
- Journal of Functional Foods
- volume
- 23
- pages
- 12 pages
- publisher
- Elsevier
- external identifiers
-
- wos:000376145200002
- scopus:84959159638
- ISSN
- 1756-4646
- DOI
- 10.1016/j.jff.2016.02.015
- language
- English
- LU publication?
- yes
- id
- 3445335c-020d-4224-8714-51a188f2b38c
- date added to LUP
- 2016-05-10 09:33:30
- date last changed
- 2024-08-09 09:35:05
@article{3445335c-020d-4224-8714-51a188f2b38c, abstract = {{<p>The influence of oat and barley β-glucans on some features of diverse probiotic strains was investigated. Neither barley nor oat β-glucans supported the growth of any of the investigated strains when used as the sole carbon source in fermentation media. No protective effect by β-glucans was observed on bacterial survival to in vitro simulation of the human digestive tract. Moreover, the presence of β-glucans did not enhance the ability of probiotic bacteria to adhere on human intestinal cells. The immunomodulatory activities of probiotics, β-glucans, and their combinations were studied and compared in vitro by transcriptional analysis of immune-related genes on LPS-stimulated THP-1 macrophages. Immune modulating properties were evidenced. In particular, mixtures of probiotic microorganisms and barley β-glucans exhibited synergistic effects in modulating the transcriptional level of several immune-related genes, leading to an overall enhanced anti-inflammatory effect. Together, these findings suggest a promising application of probiotic bacteria and β-glucans in the preparation of dietary mixtures presenting health-promoting features such as immunomodulatory properties.</p>}}, author = {{Arena, Mattia Pia and Russo, Pasquale and Capozzi, Vittorio and Rascón, Ana and Felis, Giovanna E. and Spano, Giuseppe and Fiocco, Daniela}}, issn = {{1756-4646}}, keywords = {{Beta Glucan (PubChem CID: 9202437); Immune system; Prebiotics; Probiotics; Relative gene expression; Synbiotics; β-glucan}}, language = {{eng}}, month = {{05}}, pages = {{12--23}}, publisher = {{Elsevier}}, series = {{Journal of Functional Foods}}, title = {{Combinations of cereal β-glucans and probiotics can enhance the anti-inflammatory activity on host cells by a synergistic effect}}, url = {{http://dx.doi.org/10.1016/j.jff.2016.02.015}}, doi = {{10.1016/j.jff.2016.02.015}}, volume = {{23}}, year = {{2016}}, }