Male sex and vascular risk factors affect cystatin C-derived renal function in older people without diabetes or overt vascular disease.
(2014) In Age and Ageing 43(3). p.411-417- Abstract
- Background/objectives: to explore the effect of ageing on renal function with cystatin C as the marker of glomerular filtration rate (GFR) in the general population without vascular disease or diabetes.Design: a cross-sectional analysis of a healthy subset from the Good Aging in Skåne-cohort study representative of the Swedish general population.Subjects: 1252 participants without vascular disease and diabetes (43.9% men) of whom 203 were over 80 years old were included from the original cohort of 2931.Methods: plasma cystatin C and plasma creatinine were used as markers for GFR. Estimated GFR (eGFR) was calculated with three chronic kidney disease epidemiology collaboration (CKD-EPI) formulas involving cystatin C, creatinine or... (More)
- Background/objectives: to explore the effect of ageing on renal function with cystatin C as the marker of glomerular filtration rate (GFR) in the general population without vascular disease or diabetes.Design: a cross-sectional analysis of a healthy subset from the Good Aging in Skåne-cohort study representative of the Swedish general population.Subjects: 1252 participants without vascular disease and diabetes (43.9% men) of whom 203 were over 80 years old were included from the original cohort of 2931.Methods: plasma cystatin C and plasma creatinine were used as markers for GFR. Estimated GFR (eGFR) was calculated with three chronic kidney disease epidemiology collaboration (CKD-EPI) formulas involving cystatin C, creatinine or both.Results: the median for plasma cystatin C was 0.93 mg/l (60-69 years old), 1.04 (70-79 years old) and 1.24 (80+ years old). The difference in mg/l between the 5th and 95th percentile was 0.46, 0.62 and 0.90 for these age groups. Male sex increased the age effect on plasma cystatin C levels with 0.004 mg/l/year (P = 0.03), adjusted for vascular risk factors. Smoking, lower HDL and higher diastolic blood pressure were associated with higher cystatin C levels. 54.7% (CKD-EPI creatinine) to 73.9% (CKD-EPI cystatin C) of the 80+ had an eGFR < 60 ml/min/1.73 m(2).Conclusion: non-diabetics without overt vascular disease exhibit an age related but heterogeneous decline in renal function. The ageing effect is more pronounced in men. At least half of healthy 80+ years old could be expected to have at least CKD Stage 3 with eGFR < 60 ml/min/1.73 m(2). (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4224952
- author
- Werner, Karin LU ; Elmståhl, Sölve LU ; Christensson, Anders LU and Pihlsgård, Mats LU
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Age and Ageing
- volume
- 43
- issue
- 3
- pages
- 411 - 417
- publisher
- Oxford University Press
- external identifiers
-
- pmid:24321840
- wos:000335770900023
- scopus:84901981173
- pmid:24321840
- ISSN
- 1468-2834
- DOI
- 10.1093/ageing/aft191
- language
- English
- LU publication?
- yes
- id
- 4b10d1c1-fddf-47ad-b1b7-235a6fd2a49c (old id 4224952)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/24321840?dopt=Abstract
- date added to LUP
- 2016-04-01 10:01:20
- date last changed
- 2022-01-25 19:00:34
@article{4b10d1c1-fddf-47ad-b1b7-235a6fd2a49c, abstract = {{Background/objectives: to explore the effect of ageing on renal function with cystatin C as the marker of glomerular filtration rate (GFR) in the general population without vascular disease or diabetes.Design: a cross-sectional analysis of a healthy subset from the Good Aging in Skåne-cohort study representative of the Swedish general population.Subjects: 1252 participants without vascular disease and diabetes (43.9% men) of whom 203 were over 80 years old were included from the original cohort of 2931.Methods: plasma cystatin C and plasma creatinine were used as markers for GFR. Estimated GFR (eGFR) was calculated with three chronic kidney disease epidemiology collaboration (CKD-EPI) formulas involving cystatin C, creatinine or both.Results: the median for plasma cystatin C was 0.93 mg/l (60-69 years old), 1.04 (70-79 years old) and 1.24 (80+ years old). The difference in mg/l between the 5th and 95th percentile was 0.46, 0.62 and 0.90 for these age groups. Male sex increased the age effect on plasma cystatin C levels with 0.004 mg/l/year (P = 0.03), adjusted for vascular risk factors. Smoking, lower HDL and higher diastolic blood pressure were associated with higher cystatin C levels. 54.7% (CKD-EPI creatinine) to 73.9% (CKD-EPI cystatin C) of the 80+ had an eGFR < 60 ml/min/1.73 m(2).Conclusion: non-diabetics without overt vascular disease exhibit an age related but heterogeneous decline in renal function. The ageing effect is more pronounced in men. At least half of healthy 80+ years old could be expected to have at least CKD Stage 3 with eGFR < 60 ml/min/1.73 m(2).}}, author = {{Werner, Karin and Elmståhl, Sölve and Christensson, Anders and Pihlsgård, Mats}}, issn = {{1468-2834}}, language = {{eng}}, number = {{3}}, pages = {{411--417}}, publisher = {{Oxford University Press}}, series = {{Age and Ageing}}, title = {{Male sex and vascular risk factors affect cystatin C-derived renal function in older people without diabetes or overt vascular disease.}}, url = {{https://lup.lub.lu.se/search/files/1486362/4587334.pdf}}, doi = {{10.1093/ageing/aft191}}, volume = {{43}}, year = {{2014}}, }