Direct association between diet and the stability of human atherosclerotic plaque.
(2015) In Scientific Reports 5.- Abstract
- Mediterranean diet has been suggested to explain why coronary heart disease mortality is lower in southern than northern Europe. Dietary habits can be revealed by isotope ratio mass spectrometry (IRMS) measurement of carbon (δ(13)C) and nitrogen (δ(15)N) in biological tissues. To study if diet is associated with human plaque stability, atherosclerotic plaques from carotid endarterectomy on 56 patients (21 Portuguese and 35 Swedish) were analysed by IRMS and histology. Plaque components affecting rupture risk were measured. Swedish plaques had more apoptosis, lipids and larger cores, as well as fewer proliferating cells and SMC than the Portuguese, conferring the Swedish a more rupture-prone phenotype. Portuguese plaques contained higher... (More)
- Mediterranean diet has been suggested to explain why coronary heart disease mortality is lower in southern than northern Europe. Dietary habits can be revealed by isotope ratio mass spectrometry (IRMS) measurement of carbon (δ(13)C) and nitrogen (δ(15)N) in biological tissues. To study if diet is associated with human plaque stability, atherosclerotic plaques from carotid endarterectomy on 56 patients (21 Portuguese and 35 Swedish) were analysed by IRMS and histology. Plaque components affecting rupture risk were measured. Swedish plaques had more apoptosis, lipids and larger cores, as well as fewer proliferating cells and SMC than the Portuguese, conferring the Swedish a more rupture-prone phenotype. Portuguese plaques contained higher δ(13)C and δ(15)N than the Swedish, indicating that Portuguese plaques were more often derived from marine food. Plaque δ(13)C correlated with SMC and proliferating cells, and inversely with lipids, core size, apoptosis. Plaque δ(15)N correlated with SMC and inversely with lipids, core size and apoptosis. This is the first observational study showing that diet is reflected in plaque components associated with its vulnerability. The Portuguese plaques composition is consistent with an increased marine food intake and those plaques are more stable than those from Swedish patients. Marine-derived food is associated with plaque stability. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/8148712
- author
- Goncalves, Isabel LU ; Georgiadou, Elisavet ; Mattsson, Sören LU ; Skog, Göran ; Pedro, Luís ; Fernandes E Fernandes, José ; Dias, Nuno LU ; Engström, Gunnar LU ; Nilsson, Jan LU and Stenström, Kristina
- organization
-
- EXODIAB: Excellence of Diabetes Research in Sweden
- EpiHealth: Epidemiology for Health
- Cardiovascular Research - Translational Studies (research group)
- Cardiovascular Research - Immunity and Atherosclerosis (research group)
- Medical Radiation Physics, Malmö (research group)
- Vascular Diseases - Clinical Research (research group)
- Cardiovascular Research - Epidemiology (research group)
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Scientific Reports
- volume
- 5
- article number
- 15524
- publisher
- Nature Publishing Group
- external identifiers
-
- pmid:26490319
- wos:000363139000001
- scopus:84944897468
- pmid:26490319
- ISSN
- 2045-2322
- DOI
- 10.1038/srep15524
- language
- English
- LU publication?
- yes
- id
- 45e822d8-3f35-4f3d-b238-832a136bf57b (old id 8148712)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/26490319?dopt=Abstract
- date added to LUP
- 2016-04-01 14:24:16
- date last changed
- 2022-04-14 17:38:50
@article{45e822d8-3f35-4f3d-b238-832a136bf57b, abstract = {{Mediterranean diet has been suggested to explain why coronary heart disease mortality is lower in southern than northern Europe. Dietary habits can be revealed by isotope ratio mass spectrometry (IRMS) measurement of carbon (δ(13)C) and nitrogen (δ(15)N) in biological tissues. To study if diet is associated with human plaque stability, atherosclerotic plaques from carotid endarterectomy on 56 patients (21 Portuguese and 35 Swedish) were analysed by IRMS and histology. Plaque components affecting rupture risk were measured. Swedish plaques had more apoptosis, lipids and larger cores, as well as fewer proliferating cells and SMC than the Portuguese, conferring the Swedish a more rupture-prone phenotype. Portuguese plaques contained higher δ(13)C and δ(15)N than the Swedish, indicating that Portuguese plaques were more often derived from marine food. Plaque δ(13)C correlated with SMC and proliferating cells, and inversely with lipids, core size, apoptosis. Plaque δ(15)N correlated with SMC and inversely with lipids, core size and apoptosis. This is the first observational study showing that diet is reflected in plaque components associated with its vulnerability. The Portuguese plaques composition is consistent with an increased marine food intake and those plaques are more stable than those from Swedish patients. Marine-derived food is associated with plaque stability.}}, author = {{Goncalves, Isabel and Georgiadou, Elisavet and Mattsson, Sören and Skog, Göran and Pedro, Luís and Fernandes E Fernandes, José and Dias, Nuno and Engström, Gunnar and Nilsson, Jan and Stenström, Kristina}}, issn = {{2045-2322}}, language = {{eng}}, publisher = {{Nature Publishing Group}}, series = {{Scientific Reports}}, title = {{Direct association between diet and the stability of human atherosclerotic plaque.}}, url = {{https://lup.lub.lu.se/search/files/3957234/8839598}}, doi = {{10.1038/srep15524}}, volume = {{5}}, year = {{2015}}, }