Microstructural white matter alterations and hippocampal volumes are associated with cognitive deficits in craniopharyngioma
(2018) In European Journal of Endocrinology 178(6). p.577-587- Abstract
CONTEXT: Patients with craniopharyngioma (CP) and hypothalamic lesions (HL) have cognitive deficits. Which neural pathways are affected is unknown.
OBJECTIVE: To determine whether there is a relationship between microstructural white matter (WM) alterations detected with diffusion tensor imaging (DTI) and cognition in adults with childhood-onset CP.
DESIGN: A cross-sectional study with a median follow-up time of 22 (6-49) years after operation.
SETTING: The South Medical Region of Sweden (2.5 million inhabitants).
PARTICIPANTS: Included were 41 patients (24 women, ≥17 years) surgically treated for childhood-onset CP between 1958-2010 and 32 controls with similar age and gender distributions. HL was found in 23... (More)
CONTEXT: Patients with craniopharyngioma (CP) and hypothalamic lesions (HL) have cognitive deficits. Which neural pathways are affected is unknown.
OBJECTIVE: To determine whether there is a relationship between microstructural white matter (WM) alterations detected with diffusion tensor imaging (DTI) and cognition in adults with childhood-onset CP.
DESIGN: A cross-sectional study with a median follow-up time of 22 (6-49) years after operation.
SETTING: The South Medical Region of Sweden (2.5 million inhabitants).
PARTICIPANTS: Included were 41 patients (24 women, ≥17 years) surgically treated for childhood-onset CP between 1958-2010 and 32 controls with similar age and gender distributions. HL was found in 23 patients.
MAIN OUTCOME MEASURES: Subjects performed cognitive tests and magnetic resonance imaging, and images were analyzed using DTI of uncinate fasciculus, fornix, cingulum, hippocampus and hypothalamus as well as hippocampal volumetry.
RESULTS: Right uncinate fasciculus was significantly altered (P ≤ 0.01). Microstructural WM alterations in left ventral cingulum were significantly associated with worse performance in visual episodic memory, explaining approximately 50% of the variation. Alterations in dorsal cingulum were associated with worse performance in immediate, delayed recall and recognition, explaining 26-38% of the variation, and with visuospatial ability and executive function, explaining 19-29%. Patients who had smaller hippocampal volume had worse general knowledge (P = 0.028), and microstructural WM alterations in hippocampus were associated with a decline in general knowledge and episodic visual memory.
CONCLUSIONS: A structure to function relationship is suggested between microstructural WM alterations in cingulum and in hippocampus with cognitive deficits in CP.
(Less)
- author
- organization
-
- Diagnostic Radiology, (Lund)
- Division of Occupational and Environmental Medicine, Lund University
- Translational Neuroendocrinology (research group)
- MultiPark: Multidisciplinary research focused on Parkinson´s disease
- Neuroradiology (research group)
- BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
- publishing date
- 2018-06-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- European Journal of Endocrinology
- volume
- 178
- issue
- 6
- pages
- 11 pages
- publisher
- Society of the European Journal of Endocrinology
- external identifiers
-
- pmid:29599407
- scopus:85046571341
- ISSN
- 1479-683X
- DOI
- 10.1530/EJE-18-0081
- language
- English
- LU publication?
- yes
- id
- 862c939e-4752-436b-a216-eeb96c5075c8
- date added to LUP
- 2018-05-21 15:01:19
- date last changed
- 2024-08-05 17:42:35
@article{862c939e-4752-436b-a216-eeb96c5075c8, abstract = {{<p>CONTEXT: Patients with craniopharyngioma (CP) and hypothalamic lesions (HL) have cognitive deficits. Which neural pathways are affected is unknown.</p><p>OBJECTIVE: To determine whether there is a relationship between microstructural white matter (WM) alterations detected with diffusion tensor imaging (DTI) and cognition in adults with childhood-onset CP.</p><p>DESIGN: A cross-sectional study with a median follow-up time of 22 (6-49) years after operation.</p><p>SETTING: The South Medical Region of Sweden (2.5 million inhabitants).</p><p>PARTICIPANTS: Included were 41 patients (24 women, ≥17 years) surgically treated for childhood-onset CP between 1958-2010 and 32 controls with similar age and gender distributions. HL was found in 23 patients.</p><p>MAIN OUTCOME MEASURES: Subjects performed cognitive tests and magnetic resonance imaging, and images were analyzed using DTI of uncinate fasciculus, fornix, cingulum, hippocampus and hypothalamus as well as hippocampal volumetry.</p><p>RESULTS: Right uncinate fasciculus was significantly altered (P ≤ 0.01). Microstructural WM alterations in left ventral cingulum were significantly associated with worse performance in visual episodic memory, explaining approximately 50% of the variation. Alterations in dorsal cingulum were associated with worse performance in immediate, delayed recall and recognition, explaining 26-38% of the variation, and with visuospatial ability and executive function, explaining 19-29%. Patients who had smaller hippocampal volume had worse general knowledge (P = 0.028), and microstructural WM alterations in hippocampus were associated with a decline in general knowledge and episodic visual memory.</p><p>CONCLUSIONS: A structure to function relationship is suggested between microstructural WM alterations in cingulum and in hippocampus with cognitive deficits in CP.</p>}}, author = {{Fjalldal, S. and Follin, C. and Svärd, D. and Rylander, L. and Gabery, S. and Petersén and van Westen, D. and Sundgren, P. C. and Björkman-Burtscher, I. M. and Lätt, J. and Ekman, B. and Johanson, A. and Erfurth, E. M.}}, issn = {{1479-683X}}, language = {{eng}}, month = {{06}}, number = {{6}}, pages = {{577--587}}, publisher = {{Society of the European Journal of Endocrinology}}, series = {{European Journal of Endocrinology}}, title = {{Microstructural white matter alterations and hippocampal volumes are associated with cognitive deficits in craniopharyngioma}}, url = {{http://dx.doi.org/10.1530/EJE-18-0081}}, doi = {{10.1530/EJE-18-0081}}, volume = {{178}}, year = {{2018}}, }