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Probiotic-Reduced Inflammaging in Older Adults : A Randomized, Double-Blind, Placebo-Controlled Trial

Lazou-Ahrén, Irini ; Björklund, Malin ; Molin, Göran LU ; Xu, Jie ; Önning, Gunilla ; Elmståhl, Sölve LU and Jeppsson, Bengt LU (2024) In Probiotics and Antimicrobial Proteins
Abstract

The disparity between increased lifespan and healthy aging, marked by prevalent “inflammaging”, highlights the global challenge in care of older persons. This study explored the anti-inflammatory effects of Lactiplantibacillus plantarum HEAL9 (LpHEAL9), alone or combined with berries, on older volunteers with chronic low-grade inflammation (LGI). It was a randomized, double-blind, placebo-controlled trial, with a total of 66 volunteers (> 70 years old), randomly assigned, and equally distributed, to placebo, LpHEAL9 or LpHEAL9 + Berries group. After a 2-week run-in period, participants underwent a 4-week dietary intervention. Intake of LpHEAL9 showed a trend towards reduction in serum CRP but without reaching statistical... (More)

The disparity between increased lifespan and healthy aging, marked by prevalent “inflammaging”, highlights the global challenge in care of older persons. This study explored the anti-inflammatory effects of Lactiplantibacillus plantarum HEAL9 (LpHEAL9), alone or combined with berries, on older volunteers with chronic low-grade inflammation (LGI). It was a randomized, double-blind, placebo-controlled trial, with a total of 66 volunteers (> 70 years old), randomly assigned, and equally distributed, to placebo, LpHEAL9 or LpHEAL9 + Berries group. After a 2-week run-in period, participants underwent a 4-week dietary intervention. Intake of LpHEAL9 showed a trend towards reduction in serum CRP but without reaching statistical significance. However, LpHEAL9 significantly decreased fecal calprotectin levels compared to placebo. LpHEAL9+Berries did not show any effect on inflammation. Both probiotic groups showed a trend in improving cognitive function albeit not reaching statistical significance. Our findings suggest that the probiotic strain L. plantarum HEAL9 has a modest impact on LGI in a healthy older population (ClinicalTrials.gov ID: NCT02342496).

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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
in press
subject
keywords
Calprotectin, CRP, Inflammaging, L. plantarum, Lactiplantibacillus plantarum HEAL9, Low-grade inflammation, Older
in
Probiotics and Antimicrobial Proteins
publisher
Springer
external identifiers
  • pmid:38896223
  • scopus:85196323067
ISSN
1867-1306
DOI
10.1007/s12602-024-10310-7
language
English
LU publication?
yes
id
05a7477d-98e0-4640-b441-583ccf91fe50
date added to LUP
2024-09-09 10:44:31
date last changed
2024-09-10 03:00:09
@article{05a7477d-98e0-4640-b441-583ccf91fe50,
  abstract     = {{<p>The disparity between increased lifespan and healthy aging, marked by prevalent “inflammaging”, highlights the global challenge in care of older persons. This study explored the anti-inflammatory effects of Lactiplantibacillus plantarum HEAL9 (LpHEAL9), alone or combined with berries, on older volunteers with chronic low-grade inflammation (LGI). It was a randomized, double-blind, placebo-controlled trial, with a total of 66 volunteers (&gt; 70 years old), randomly assigned, and equally distributed, to placebo, LpHEAL9 or LpHEAL9 + Berries group. After a 2-week run-in period, participants underwent a 4-week dietary intervention. Intake of LpHEAL9 showed a trend towards reduction in serum CRP but without reaching statistical significance. However, LpHEAL9 significantly decreased fecal calprotectin levels compared to placebo. LpHEAL9+Berries did not show any effect on inflammation. Both probiotic groups showed a trend in improving cognitive function albeit not reaching statistical significance. Our findings suggest that the probiotic strain L. plantarum HEAL9 has a modest impact on LGI in a healthy older population (ClinicalTrials.gov ID: NCT02342496).</p>}},
  author       = {{Lazou-Ahrén, Irini and Björklund, Malin and Molin, Göran and Xu, Jie and Önning, Gunilla and Elmståhl, Sölve and Jeppsson, Bengt}},
  issn         = {{1867-1306}},
  keywords     = {{Calprotectin; CRP; Inflammaging; L. plantarum; Lactiplantibacillus plantarum HEAL9; Low-grade inflammation; Older}},
  language     = {{eng}},
  publisher    = {{Springer}},
  series       = {{Probiotics and Antimicrobial Proteins}},
  title        = {{Probiotic-Reduced Inflammaging in Older Adults : A Randomized, Double-Blind, Placebo-Controlled Trial}},
  url          = {{http://dx.doi.org/10.1007/s12602-024-10310-7}},
  doi          = {{10.1007/s12602-024-10310-7}},
  year         = {{2024}},
}