A stochastic model for subcellular dosimetry in boron neutron capture therapy
Ceberg, Crister LU
; Persson, Anders
; Brun, Arne
LU
; Huiskamp, René
; Salford, Leif
LU
and Persson, Bertil R
LU
(1995)
In Physics in Medicine and Biology
40(11).
p.1819-1830
- Abstract
- The therapeutic effectiveness of boron neutron capture therapy is highly dependent on the microscopic distribution of the administered boron compound. Two boron compounds with different uptake mechanisms in the tumour cells may thus cause effects of different degrees even if the macroscopic boron concentrations in the tumour tissue are the same. This difference is normally expressed quantitatively by the so-called relative local efficiency (RLE). In this work, a stochastic model for the subcellular dosimetry has been developed. This model can be used to calculate the probability for an energy deposition above a certain threshold level in the cell nucleus due to a single neutron capture reaction. If a threshold cell-kill function is... (More)
- The therapeutic effectiveness of boron neutron capture therapy is highly dependent on the microscopic distribution of the administered boron compound. Two boron compounds with different uptake mechanisms in the tumour cells may thus cause effects of different degrees even if the macroscopic boron concentrations in the tumour tissue are the same. This difference is normally expressed quantitatively by the so-called relative local efficiency (RLE). In this work, a stochastic model for the subcellular dosimetry has been developed. This model can be used to calculate the probability for an energy deposition above a certain threshold level in the cell nucleus due to a single neutron capture reaction. If a threshold cell-kill function is assumed, and if the dose is low enough that multiple energy depositions are rare, the model can also be applied to calculations of the survival probability for a cell population. Subcellular boron distributions in rats carrying RG 2 rat gliomas were measured by subcellular fractionation after administration of two different boron compounds: a sulphydryl boron hydride (BSH) and a boronated porphyrin (BOPP). Based on these data, the RLE factors were then calculated for these compounds using the stochastic model. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1109451
- author
- Ceberg, Crister
LU
; Persson, Anders
; Brun, Arne
LU
; Huiskamp, René
; Salford, Leif
LU
and Persson, Bertil R
LU
- organization
- publishing date
- 1995
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Physics in Medicine and Biology
- volume
- 40
- issue
- 11
- pages
- 1819 - 1830
- publisher
- IOP Publishing
- external identifiers
-
- pmid:8587934
- scopus:0029582886
- ISSN
- 1361-6560
- DOI
- 10.1088/0031-9155/40/11/004
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neurosurgery (013026000), Pathology, (Lund) (013030000), Radiation Physics, Lund (013034000)
- id
- 3f77ee55-6f9a-474a-b7be-7d908e41b9d8 (old id 1109451)
- date added to LUP
- 2016-04-01 12:11:53
- date last changed
- 2021-01-03 03:13:40
@article{3f77ee55-6f9a-474a-b7be-7d908e41b9d8,
abstract = {{The therapeutic effectiveness of boron neutron capture therapy is highly dependent on the microscopic distribution of the administered boron compound. Two boron compounds with different uptake mechanisms in the tumour cells may thus cause effects of different degrees even if the macroscopic boron concentrations in the tumour tissue are the same. This difference is normally expressed quantitatively by the so-called relative local efficiency (RLE). In this work, a stochastic model for the subcellular dosimetry has been developed. This model can be used to calculate the probability for an energy deposition above a certain threshold level in the cell nucleus due to a single neutron capture reaction. If a threshold cell-kill function is assumed, and if the dose is low enough that multiple energy depositions are rare, the model can also be applied to calculations of the survival probability for a cell population. Subcellular boron distributions in rats carrying RG 2 rat gliomas were measured by subcellular fractionation after administration of two different boron compounds: a sulphydryl boron hydride (BSH) and a boronated porphyrin (BOPP). Based on these data, the RLE factors were then calculated for these compounds using the stochastic model.}},
author = {{Ceberg, Crister and Persson, Anders and Brun, Arne and Huiskamp, René and Salford, Leif and Persson, Bertil R}},
issn = {{1361-6560}},
language = {{eng}},
number = {{11}},
pages = {{1819--1830}},
publisher = {{IOP Publishing}},
series = {{Physics in Medicine and Biology}},
title = {{A stochastic model for subcellular dosimetry in boron neutron capture therapy}},
url = {{http://dx.doi.org/10.1088/0031-9155/40/11/004}},
doi = {{10.1088/0031-9155/40/11/004}},
volume = {{40}},
year = {{1995}},
}