Major surgery seems not to influence HIV disease progression in haemophilia patients
(1998) In British Journal of Haematology 103(1). p.10-14- Abstract
- The influence of major surgery on HIV disease progression and decline in CD4+ cell count was evaluated in 23 seropositive haemophilia patients. 24 HIV-infected patients served as non-operated controls. In addition, 32 age-matched seronegative subjects were included. The follow-up time was up to 5 years. During the course of the study, eight of the operated (35%) and 11 of the non-operated (48%) subjects developed HIV-related symptoms (P=0.267). The relative risk for developing HIV-related symptoms after surgery was 0.60 (95% CI 0.25; 1.48). A significant decline in CD4+ cell counts was observed in both the surgery (4.0 x 10(6)/l/month, 95% CI 2.0; 6.0 x 10(6), P=0.001) and the non-surgery (4.0 x 10(6)/l/month, 95% CI 2.0; 6.0 x 10(6),... (More)
- The influence of major surgery on HIV disease progression and decline in CD4+ cell count was evaluated in 23 seropositive haemophilia patients. 24 HIV-infected patients served as non-operated controls. In addition, 32 age-matched seronegative subjects were included. The follow-up time was up to 5 years. During the course of the study, eight of the operated (35%) and 11 of the non-operated (48%) subjects developed HIV-related symptoms (P=0.267). The relative risk for developing HIV-related symptoms after surgery was 0.60 (95% CI 0.25; 1.48). A significant decline in CD4+ cell counts was observed in both the surgery (4.0 x 10(6)/l/month, 95% CI 2.0; 6.0 x 10(6), P=0.001) and the non-surgery (4.0 x 10(6)/l/month, 95% CI 2.0; 6.0 x 10(6), P=0.004) seropositive subgroup, but no difference between the two subgroups was seen (P=0.793). HIV (6.0 x 10(6)/l/month, 95% CI 2.1; 9.9 x 10(6), P=0.0005) but not surgery (-1.0 x 10(6)/l/ month, 95% CI -3.0; 0.96 x 10(6), P=0.647) was an independent predictor for the decline in CD34+ cell count. No interaction effect was observed between HIV infection and surgery (P=0.361). The annual amount of factor concentrate used for regular replacement therapy did not influence the decline in CD4+ cell count (P=0.492). We conclude that major surgery may be considered in symptom-free HIV-seropositive haemophilia patients, with CD4+ cell counts > or = 0.20 x 10(9)/l under similar premises as for seronegative subjects. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1113332
- author
- Astermark, Jan LU ; Löfqvist, Thomas ; Schulman, S ; Stigendal, L ; Lethagen, Stefan LU ; Nilsson, Inga Marie and Berntorp, Erik LU
- organization
- publishing date
- 1998
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- haemophilia, surgery, HIV, CD4+ cells, AIDS
- in
- British Journal of Haematology
- volume
- 103
- issue
- 1
- pages
- 10 - 14
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:9792282
- scopus:0031656537
- ISSN
- 0007-1048
- DOI
- 10.1046/j.1365-2141.1998.00961.x
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Emergency medicine/Medicine/Surgery (013240200), Clinical Coagulation Research Unit (013242510)
- id
- 65228068-f1aa-447d-8168-24da771f9635 (old id 1113332)
- date added to LUP
- 2016-04-01 12:19:11
- date last changed
- 2022-01-27 01:56:16
@article{65228068-f1aa-447d-8168-24da771f9635, abstract = {{The influence of major surgery on HIV disease progression and decline in CD4+ cell count was evaluated in 23 seropositive haemophilia patients. 24 HIV-infected patients served as non-operated controls. In addition, 32 age-matched seronegative subjects were included. The follow-up time was up to 5 years. During the course of the study, eight of the operated (35%) and 11 of the non-operated (48%) subjects developed HIV-related symptoms (P=0.267). The relative risk for developing HIV-related symptoms after surgery was 0.60 (95% CI 0.25; 1.48). A significant decline in CD4+ cell counts was observed in both the surgery (4.0 x 10(6)/l/month, 95% CI 2.0; 6.0 x 10(6), P=0.001) and the non-surgery (4.0 x 10(6)/l/month, 95% CI 2.0; 6.0 x 10(6), P=0.004) seropositive subgroup, but no difference between the two subgroups was seen (P=0.793). HIV (6.0 x 10(6)/l/month, 95% CI 2.1; 9.9 x 10(6), P=0.0005) but not surgery (-1.0 x 10(6)/l/ month, 95% CI -3.0; 0.96 x 10(6), P=0.647) was an independent predictor for the decline in CD34+ cell count. No interaction effect was observed between HIV infection and surgery (P=0.361). The annual amount of factor concentrate used for regular replacement therapy did not influence the decline in CD4+ cell count (P=0.492). We conclude that major surgery may be considered in symptom-free HIV-seropositive haemophilia patients, with CD4+ cell counts > or = 0.20 x 10(9)/l under similar premises as for seronegative subjects.}}, author = {{Astermark, Jan and Löfqvist, Thomas and Schulman, S and Stigendal, L and Lethagen, Stefan and Nilsson, Inga Marie and Berntorp, Erik}}, issn = {{0007-1048}}, keywords = {{haemophilia; surgery; HIV; CD4+ cells; AIDS}}, language = {{eng}}, number = {{1}}, pages = {{10--14}}, publisher = {{Wiley-Blackwell}}, series = {{British Journal of Haematology}}, title = {{Major surgery seems not to influence HIV disease progression in haemophilia patients}}, url = {{http://dx.doi.org/10.1046/j.1365-2141.1998.00961.x}}, doi = {{10.1046/j.1365-2141.1998.00961.x}}, volume = {{103}}, year = {{1998}}, }