A Pilot Study of Rapid Cooling by Cold Saline and Endovascular Cooling Before Reperfusion in Patients With ST-Elevation Myocardial Infarction.
(2010) In Circulation. Cardiovascular Interventions 3. p.400-407- Abstract
- Background-Experimental studies have shown that induction of hypothermia before reperfusion of acute coronary occlusion reduces infarct size. Previous clinical studies, however, have not been able to show this effect, which is believed to be mainly because therapeutic temperature was not reached before reperfusion in the majority of the patients. We aimed to evaluate the safety and feasibility of rapidly induced hypothermia by infusion of cold saline and endovascular cooling catheter before reperfusion in patients with acute myocardial infarction. METHODS AND RESULTS: =0.12). Despite similar duration of ischemia (174+/-51 minutes versus 174+/-62 minutes, hypothermia versus control, P=1.00), infarct size normalized to myocardium at risk was... (More)
- Background-Experimental studies have shown that induction of hypothermia before reperfusion of acute coronary occlusion reduces infarct size. Previous clinical studies, however, have not been able to show this effect, which is believed to be mainly because therapeutic temperature was not reached before reperfusion in the majority of the patients. We aimed to evaluate the safety and feasibility of rapidly induced hypothermia by infusion of cold saline and endovascular cooling catheter before reperfusion in patients with acute myocardial infarction. METHODS AND RESULTS: =0.12). Despite similar duration of ischemia (174+/-51 minutes versus 174+/-62 minutes, hypothermia versus control, P=1.00), infarct size normalized to myocardium at risk was reduced by 38% in the hypothermia group compared with the control group (29.8+/-12.6% versus 48.0+/-21.6%, P=0.041). This was supported by a significant decrease in both peak and cumulative release of Troponin T in the hypothermia group (P=0.01 and P=0.03, respectively). Conclusions-The protocol demonstrates the ability to reach a core body temperature of <35 degrees C before reperfusion in all patients without delaying primary percutaneous coronary intervention and that combination hypothermia as an adjunct therapy in acute myocardial infarction may reduce infarct size at 3 days as measured by MRI. Clinical Trial Registration-URL: http://clinicaltrials.gov. Unique identifier: NCT00417638. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1665027
- author
- Götberg, Matthias
LU
; Olivecrona, Göran
LU
; Koul, Sasha
LU
; Carlsson, Marcus
LU
; Engblom, Henrik
LU
; Ugander, Martin
LU
; vanderPals, Jesper
LU
; Algotsson, Lars
LU
; Arheden, Håkan
LU
and Erlinge, David
LU
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Circulation. Cardiovascular Interventions
- volume
- 3
- pages
- 400 - 407
- publisher
- American Heart Association
- external identifiers
-
- wos:000283160500007
- pmid:20736446
- scopus:78650120763
- pmid:20736446
- ISSN
- 1941-7632
- DOI
- 10.1161/CIRCINTERVENTIONS.110.957902
- language
- English
- LU publication?
- yes
- id
- 68e0fb14-9c35-429a-908b-d5b17ca6e292 (old id 1665027)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/20736446?dopt=Abstract
- date added to LUP
- 2016-04-04 08:56:17
- date last changed
- 2022-03-15 17:16:28
@article{68e0fb14-9c35-429a-908b-d5b17ca6e292, abstract = {{Background-Experimental studies have shown that induction of hypothermia before reperfusion of acute coronary occlusion reduces infarct size. Previous clinical studies, however, have not been able to show this effect, which is believed to be mainly because therapeutic temperature was not reached before reperfusion in the majority of the patients. We aimed to evaluate the safety and feasibility of rapidly induced hypothermia by infusion of cold saline and endovascular cooling catheter before reperfusion in patients with acute myocardial infarction. METHODS AND RESULTS: =0.12). Despite similar duration of ischemia (174+/-51 minutes versus 174+/-62 minutes, hypothermia versus control, P=1.00), infarct size normalized to myocardium at risk was reduced by 38% in the hypothermia group compared with the control group (29.8+/-12.6% versus 48.0+/-21.6%, P=0.041). This was supported by a significant decrease in both peak and cumulative release of Troponin T in the hypothermia group (P=0.01 and P=0.03, respectively). Conclusions-The protocol demonstrates the ability to reach a core body temperature of <35 degrees C before reperfusion in all patients without delaying primary percutaneous coronary intervention and that combination hypothermia as an adjunct therapy in acute myocardial infarction may reduce infarct size at 3 days as measured by MRI. Clinical Trial Registration-URL: http://clinicaltrials.gov. Unique identifier: NCT00417638.}}, author = {{Götberg, Matthias and Olivecrona, Göran and Koul, Sasha and Carlsson, Marcus and Engblom, Henrik and Ugander, Martin and vanderPals, Jesper and Algotsson, Lars and Arheden, Håkan and Erlinge, David}}, issn = {{1941-7632}}, language = {{eng}}, pages = {{400--407}}, publisher = {{American Heart Association}}, series = {{Circulation. Cardiovascular Interventions}}, title = {{A Pilot Study of Rapid Cooling by Cold Saline and Endovascular Cooling Before Reperfusion in Patients With ST-Elevation Myocardial Infarction.}}, url = {{http://dx.doi.org/10.1161/CIRCINTERVENTIONS.110.957902}}, doi = {{10.1161/CIRCINTERVENTIONS.110.957902}}, volume = {{3}}, year = {{2010}}, }