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Pre-diagnostic meat and fibre intakes in relation to colorectal cancer survival in the European Prospective Investigation into Cancer and Nutrition

Ward, Heather A ; Norat, Teresa ; Overvad, Kim ; Dahm, Christina C ; Bueno-de-Mesquita, H Bas ; Jenab, Mazda ; Fedirko, Veronika ; van Duijnhoven, Fränzel J B ; Skeie, Guri and Romaguera-Bosch, Dora , et al. (2016) In British Journal of Nutrition 116(2). p.25-316
Abstract

Improvements in colorectal cancer (CRC) detection and treatment have led to greater numbers of CRC survivors, for whom there is limited evidence on which to provide dietary guidelines to improve survival outcomes. Higher intake of red and processed meat and lower intake of fibre are associated with greater risk of developing CRC, but there is limited evidence regarding associations with survival after CRC diagnosis. Among 3789 CRC cases in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, pre-diagnostic consumption of red meat, processed meat, poultry and dietary fibre was examined in relation to CRC-specific mortality (n 1008) and all-cause mortality (n 1262) using multivariable Cox regression models,... (More)

Improvements in colorectal cancer (CRC) detection and treatment have led to greater numbers of CRC survivors, for whom there is limited evidence on which to provide dietary guidelines to improve survival outcomes. Higher intake of red and processed meat and lower intake of fibre are associated with greater risk of developing CRC, but there is limited evidence regarding associations with survival after CRC diagnosis. Among 3789 CRC cases in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, pre-diagnostic consumption of red meat, processed meat, poultry and dietary fibre was examined in relation to CRC-specific mortality (n 1008) and all-cause mortality (n 1262) using multivariable Cox regression models, adjusted for CRC risk factors. Pre-diagnostic red meat, processed meat or fibre intakes (defined as quartiles and continuous grams per day) were not associated with CRC-specific or all-cause mortality among CRC survivors; however, a marginal trend across quartiles of processed meat in relation to CRC mortality was detected (P 0·053). Pre-diagnostic poultry intake was inversely associated with all-cause mortality among women (hazard ratio (HR)/20 g/d 0·92; 95 % CI 0·84, 1·00), but not among men (HR 1·00; 95 % CI 0·91, 1·09) (P for heterogeneity=0·10). Pre-diagnostic intake of red meat or fibre is not associated with CRC survival in the EPIC cohort. There is suggestive evidence of an association between poultry intake and all-cause mortality among female CRC survivors and between processed meat intake and CRC-specific mortality; however, further research using post-diagnostic dietary data is required to confirm this relationship.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
British Journal of Nutrition
volume
116
issue
2
pages
10 pages
publisher
Cambridge University Press
external identifiers
  • scopus:84969722251
  • wos:000379136100012
  • pmid:27193442
ISSN
1475-2662
DOI
10.1017/S0007114516001859
language
English
LU publication?
yes
id
1eaef381-0a8c-4e28-ac1d-373c785b5df1
date added to LUP
2016-06-30 12:35:01
date last changed
2025-01-25 10:02:40
@article{1eaef381-0a8c-4e28-ac1d-373c785b5df1,
  abstract     = {{<p>Improvements in colorectal cancer (CRC) detection and treatment have led to greater numbers of CRC survivors, for whom there is limited evidence on which to provide dietary guidelines to improve survival outcomes. Higher intake of red and processed meat and lower intake of fibre are associated with greater risk of developing CRC, but there is limited evidence regarding associations with survival after CRC diagnosis. Among 3789 CRC cases in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, pre-diagnostic consumption of red meat, processed meat, poultry and dietary fibre was examined in relation to CRC-specific mortality (n 1008) and all-cause mortality (n 1262) using multivariable Cox regression models, adjusted for CRC risk factors. Pre-diagnostic red meat, processed meat or fibre intakes (defined as quartiles and continuous grams per day) were not associated with CRC-specific or all-cause mortality among CRC survivors; however, a marginal trend across quartiles of processed meat in relation to CRC mortality was detected (P 0·053). Pre-diagnostic poultry intake was inversely associated with all-cause mortality among women (hazard ratio (HR)/20 g/d 0·92; 95 % CI 0·84, 1·00), but not among men (HR 1·00; 95 % CI 0·91, 1·09) (P for heterogeneity=0·10). Pre-diagnostic intake of red meat or fibre is not associated with CRC survival in the EPIC cohort. There is suggestive evidence of an association between poultry intake and all-cause mortality among female CRC survivors and between processed meat intake and CRC-specific mortality; however, further research using post-diagnostic dietary data is required to confirm this relationship.</p>}},
  author       = {{Ward, Heather A and Norat, Teresa and Overvad, Kim and Dahm, Christina C and Bueno-de-Mesquita, H Bas and Jenab, Mazda and Fedirko, Veronika and van Duijnhoven, Fränzel J B and Skeie, Guri and Romaguera-Bosch, Dora and Tjønneland, Anne and Olsen, Anja and Carbonnel, Franck and Affret, Aurélie and Boutron-Ruault, Marie-Christine and Katzke, Verena and Kühn, Tilman and Aleksandrova, Krassimira and Boeing, Heiner and Trichopoulou, Antonia and Lagiou, Pagona and Bamia, Christina and Palli, Domenico and Sieri, Sabina and Tumino, Rosario and Naccarati, Alessio and Mattiello, Amalia and Peeters, Petra H and Weiderpass, Elisabete and Åsli, Lene Angell and Jakszyn, Paula and Ramón Quirós, J and Sánchez, María-José and Dorronsoro, Miren and Huerta, José-María and Barricarte, Aurelio and Jirström, Karin and Ericson, Ulrika and Johansson, Ingegerd and Gylling, Björn and Bradbury, Kathryn E and Khaw, Kay-Tee and Wareham, Nicholas J and Stepien, Magdalena and Freisling, Heinz and Murphy, Neil and Cross, Amanda J and Riboli, Elio}},
  issn         = {{1475-2662}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{25--316}},
  publisher    = {{Cambridge University Press}},
  series       = {{British Journal of Nutrition}},
  title        = {{Pre-diagnostic meat and fibre intakes in relation to colorectal cancer survival in the European Prospective Investigation into Cancer and Nutrition}},
  url          = {{http://dx.doi.org/10.1017/S0007114516001859}},
  doi          = {{10.1017/S0007114516001859}},
  volume       = {{116}},
  year         = {{2016}},
}