Colorectal Oncogenesis and Inflammation in a Rat Model Based on Chronic Inflammation due to Cycling DSS Treatments.
(2011) In Gastroenterology Research and Practice 2011.- Abstract
- Inflammation is known to be linked with development of colorectal cancer, and the aim was to assess the malignant potential and degree of inflammation in a dextran-sulphate-sodium-(DSS-) induced cyclic colonic tumour model (CTM) in rats and to compare it with the azoxymethane-(AOM-) induced CTM model. Tumours developed in both groups, although, in the DSS group, the colonic mucosa appeared edematous and the number of haemorrhagic erosions and quantity of dysplastic lesions were higher as well as the mucosal concentration of myeloperoxidase and faecal viable count of Enterobacteriaceae. The livers were affected as evaluated by steatosis, parenchymal loss, haemorrhage, and inflammatory infiltrations, and higher proportions of acetate and... (More)
- Inflammation is known to be linked with development of colorectal cancer, and the aim was to assess the malignant potential and degree of inflammation in a dextran-sulphate-sodium-(DSS-) induced cyclic colonic tumour model (CTM) in rats and to compare it with the azoxymethane-(AOM-) induced CTM model. Tumours developed in both groups, although, in the DSS group, the colonic mucosa appeared edematous and the number of haemorrhagic erosions and quantity of dysplastic lesions were higher as well as the mucosal concentration of myeloperoxidase and faecal viable count of Enterobacteriaceae. The livers were affected as evaluated by steatosis, parenchymal loss, haemorrhage, and inflammatory infiltrations, and higher proportions of acetate and lower proportions of butyrate in colonic content were found. The DSS model seems to mimic the clinical situation and may be valuable for investigation of inflammation-related dysplasia and colon cancer, as well as for altered liver function by endogenous inflammatory mediators. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2200421
- author
- Håkansson, Åsa LU ; Bränning, Camilla LU ; Molin, Göran LU ; Adawi, Diya LU ; Hagslätt, Marie-Louise ; Nyman, Margareta LU ; Jeppsson, Bengt LU and Ahrné, Siv LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Gastroenterology Research and Practice
- volume
- 2011
- article number
- 924045
- publisher
- Hindawi Limited
- external identifiers
-
- wos:000298432600001
- pmid:22007198
- scopus:84855268709
- pmid:22007198
- ISSN
- 1687-630X
- DOI
- 10.1155/2011/924045
- language
- English
- LU publication?
- yes
- id
- 14fe07c8-b731-46eb-a8c4-c5c9978a60cf (old id 2200421)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/22007198?dopt=Abstract
- date added to LUP
- 2016-04-01 10:21:53
- date last changed
- 2023-10-26 08:36:13
@article{14fe07c8-b731-46eb-a8c4-c5c9978a60cf, abstract = {{Inflammation is known to be linked with development of colorectal cancer, and the aim was to assess the malignant potential and degree of inflammation in a dextran-sulphate-sodium-(DSS-) induced cyclic colonic tumour model (CTM) in rats and to compare it with the azoxymethane-(AOM-) induced CTM model. Tumours developed in both groups, although, in the DSS group, the colonic mucosa appeared edematous and the number of haemorrhagic erosions and quantity of dysplastic lesions were higher as well as the mucosal concentration of myeloperoxidase and faecal viable count of Enterobacteriaceae. The livers were affected as evaluated by steatosis, parenchymal loss, haemorrhage, and inflammatory infiltrations, and higher proportions of acetate and lower proportions of butyrate in colonic content were found. The DSS model seems to mimic the clinical situation and may be valuable for investigation of inflammation-related dysplasia and colon cancer, as well as for altered liver function by endogenous inflammatory mediators.}}, author = {{Håkansson, Åsa and Bränning, Camilla and Molin, Göran and Adawi, Diya and Hagslätt, Marie-Louise and Nyman, Margareta and Jeppsson, Bengt and Ahrné, Siv}}, issn = {{1687-630X}}, language = {{eng}}, publisher = {{Hindawi Limited}}, series = {{Gastroenterology Research and Practice}}, title = {{Colorectal Oncogenesis and Inflammation in a Rat Model Based on Chronic Inflammation due to Cycling DSS Treatments.}}, url = {{https://lup.lub.lu.se/search/files/1782583/2224969.pdf}}, doi = {{10.1155/2011/924045}}, volume = {{2011}}, year = {{2011}}, }