Rye bran alkylresorcinols suppress adipocyte lipolysis and hormone-sensitive lipase activity
(2011) In Molecular Nutrition and Food Research 55. p.290-293- Abstract
- The effects of alkylresorcinols (ARs) isolated from rye bran on adipocyte lipolysis, hormone-sensitive lipase activity and phosphorylation and on phosphorylation of protein kinase A substrates were studied. Preincubation with ARs for 18 h suppressed catecholamine-stimulated lipolysis in 3T3-L1 adipocytes. Furthermore, phosphorylation of hormone-sensitive lipase (HSL), a key lipase responsible for stimulated lipolysis, and phosphorylation of protein kinase A substrates, were diminished after preincubation with ARs, whereas HSL protein expression was unaltered. ARs were also shown to inhibit HSL activity in an in vitro assay.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2594765
- author
- Axling, Ulrika LU ; Dey, Estera LU ; Holm, Cecilia LU and Degerman, Eva LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Adipose tissue, Alkylresorcinols, Lipolysis, Type 2 diabetes, Whole, grain
- in
- Molecular Nutrition and Food Research
- volume
- 55
- pages
- 290 - 293
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- wos:000303246700014
- scopus:80053269621
- pmid:21887818
- ISSN
- 1613-4133
- DOI
- 10.1002/mnfr.201100231
- project
- ANTIDIABETIC FOOD CENTRE
- language
- English
- LU publication?
- yes
- id
- e4238658-5601-4280-9c8c-6e4b7f2c710b (old id 2594765)
- date added to LUP
- 2016-04-01 10:35:53
- date last changed
- 2022-05-25 05:15:23
@article{e4238658-5601-4280-9c8c-6e4b7f2c710b, abstract = {{The effects of alkylresorcinols (ARs) isolated from rye bran on adipocyte lipolysis, hormone-sensitive lipase activity and phosphorylation and on phosphorylation of protein kinase A substrates were studied. Preincubation with ARs for 18 h suppressed catecholamine-stimulated lipolysis in 3T3-L1 adipocytes. Furthermore, phosphorylation of hormone-sensitive lipase (HSL), a key lipase responsible for stimulated lipolysis, and phosphorylation of protein kinase A substrates, were diminished after preincubation with ARs, whereas HSL protein expression was unaltered. ARs were also shown to inhibit HSL activity in an in vitro assay.}}, author = {{Axling, Ulrika and Dey, Estera and Holm, Cecilia and Degerman, Eva}}, issn = {{1613-4133}}, keywords = {{Adipose tissue; Alkylresorcinols; Lipolysis; Type 2 diabetes; Whole; grain}}, language = {{eng}}, pages = {{290--293}}, publisher = {{John Wiley & Sons Inc.}}, series = {{Molecular Nutrition and Food Research}}, title = {{Rye bran alkylresorcinols suppress adipocyte lipolysis and hormone-sensitive lipase activity}}, url = {{http://dx.doi.org/10.1002/mnfr.201100231}}, doi = {{10.1002/mnfr.201100231}}, volume = {{55}}, year = {{2011}}, }