Inflammatory potential of diet and risk of nonalcoholic fatty liver disease : a prospective cohort study
(2022) In European Journal of Clinical Nutrition 76(8). p.1125-1132- Abstract
Background/objectives: Diet is an important factor that can exacerbate or ameliorate chronic inflammation, which has been implicated in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). However, no prospective study has yet investigated the relation between the inflammatory potential of diet and NAFLD. The aim of this study was to investigate the association between the inflammatory potential of the diet and the risk of NAFLD. Subject/methods: The study included 12,877 participants aged over 18 years (mean [standard deviation]: 39.4 [11.5] years). Dietary intake was assessed at baseline through food frequency questionnaires. Using white blood cell count as the inflammatory marker, we newly created a dietary inflammatory... (More)
Background/objectives: Diet is an important factor that can exacerbate or ameliorate chronic inflammation, which has been implicated in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). However, no prospective study has yet investigated the relation between the inflammatory potential of diet and NAFLD. The aim of this study was to investigate the association between the inflammatory potential of the diet and the risk of NAFLD. Subject/methods: The study included 12,877 participants aged over 18 years (mean [standard deviation]: 39.4 [11.5] years). Dietary intake was assessed at baseline through food frequency questionnaires. Using white blood cell count as the inflammatory marker, we newly created a dietary inflammatory potential score by reduced rank regression and stepwise linear regression. NAFLD was identified by abdominal ultrasound during yearly health checkups. Cox proportional hazards regression models were used to estimate the association between the dietary inflammatory potential score and the risk of NAFLD. Results: During a median follow-up period of 4.2 years, 2744 first incident cases of NAFLD occurred. After adjustment for potential confounders, the multivariable hazards ratios (95% confidence intervals) for NAFLD across increasing quartiles of the dietary inflammatory potential score were 1.00 (reference), 1.01 (0.90, 1.13), 1.15 (1.03, 1.29), and 1.26 (1.13, 1.41), with P for trend <0.0001. This positive association appeared greater in men than in women (P for interaction = 0.02). Conclusions: Our results indicate that a dietary pattern with high inflammatory potential is associated with a higher risk of NAFLD. Such findings provide the support that inflammation may be a potential mechanism linking diet to the risk of NAFLD.
(Less)
- author
- organization
- publishing date
- 2022
- type
- Contribution to journal
- publication status
- published
- subject
- in
- European Journal of Clinical Nutrition
- volume
- 76
- issue
- 8
- pages
- 1125 - 1132
- publisher
- Nature Publishing Group
- external identifiers
-
- pmid:35079162
- scopus:85123476167
- ISSN
- 0954-3007
- DOI
- 10.1038/s41430-022-01069-7
- language
- English
- LU publication?
- yes
- id
- 2d2187e3-f617-4158-832b-30cf15f589a1
- date added to LUP
- 2022-04-08 14:58:55
- date last changed
- 2025-01-06 00:02:41
@article{2d2187e3-f617-4158-832b-30cf15f589a1,
abstract = {{<p>Background/objectives: Diet is an important factor that can exacerbate or ameliorate chronic inflammation, which has been implicated in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). However, no prospective study has yet investigated the relation between the inflammatory potential of diet and NAFLD. The aim of this study was to investigate the association between the inflammatory potential of the diet and the risk of NAFLD. Subject/methods: The study included 12,877 participants aged over 18 years (mean [standard deviation]: 39.4 [11.5] years). Dietary intake was assessed at baseline through food frequency questionnaires. Using white blood cell count as the inflammatory marker, we newly created a dietary inflammatory potential score by reduced rank regression and stepwise linear regression. NAFLD was identified by abdominal ultrasound during yearly health checkups. Cox proportional hazards regression models were used to estimate the association between the dietary inflammatory potential score and the risk of NAFLD. Results: During a median follow-up period of 4.2 years, 2744 first incident cases of NAFLD occurred. After adjustment for potential confounders, the multivariable hazards ratios (95% confidence intervals) for NAFLD across increasing quartiles of the dietary inflammatory potential score were 1.00 (reference), 1.01 (0.90, 1.13), 1.15 (1.03, 1.29), and 1.26 (1.13, 1.41), with P for trend <0.0001. This positive association appeared greater in men than in women (P for interaction = 0.02). Conclusions: Our results indicate that a dietary pattern with high inflammatory potential is associated with a higher risk of NAFLD. Such findings provide the support that inflammation may be a potential mechanism linking diet to the risk of NAFLD.</p>}},
author = {{Zhang, Shunming and Meng, Ge and Zhang, Qing and Liu, Li and Wu, Hongmei and Gu, Yeqing and Wang, Yawen and Zhang, Tingjing and Wang, Xuena and Zhang, Juanjuan and Sun, Shaomei and Wang, Xing and Zhou, Ming and Jia, Qiyu and Song, Kun and Wang, Yaogang and Qi, Lu and Niu, Kaijun}},
issn = {{0954-3007}},
language = {{eng}},
number = {{8}},
pages = {{1125--1132}},
publisher = {{Nature Publishing Group}},
series = {{European Journal of Clinical Nutrition}},
title = {{Inflammatory potential of diet and risk of nonalcoholic fatty liver disease : a prospective cohort study}},
url = {{http://dx.doi.org/10.1038/s41430-022-01069-7}},
doi = {{10.1038/s41430-022-01069-7}},
volume = {{76}},
year = {{2022}},
}