Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Oscillometry findings in altered spirometry patterns and relationship to respiratory symptoms

Kjellberg, Sanna ; Åhman, Ida ; Färdig, Martin ; Zaigham, Suneela LU ; Frantz, Sophia LU ; Engström, Gunnar LU ; Janson, Christer ; Wollmer, Per LU and Malinovschi, Andrei LU (2025) In ERJ open research 11(6).
Abstract

Background Preserved ratio impaired spirometry (PRISm) and restrictive spirometry pattern (RSP) are associated with increased morbidity and mortality, but the underlying mechanisms are unclear. Impulse oscillometry (IOS) measures small airway function more sensitively than spirometry. We aim to study the prevalence of abnormal IOS findings in relation to three spirometry patterns (obstructive, PRISm and RSP), and their associations with respiratory symptoms. Methods In the Swedish CArdioPulmonary bioImage Study (SCAPIS), 10 360 participants aged 50– 64 years underwent IOS and spirometry, and answered questionnaires on respiratory symptoms. Reference values were defined using healthy never-smoking participants. Abnormality was defined as... (More)

Background Preserved ratio impaired spirometry (PRISm) and restrictive spirometry pattern (RSP) are associated with increased morbidity and mortality, but the underlying mechanisms are unclear. Impulse oscillometry (IOS) measures small airway function more sensitively than spirometry. We aim to study the prevalence of abnormal IOS findings in relation to three spirometry patterns (obstructive, PRISm and RSP), and their associations with respiratory symptoms. Methods In the Swedish CArdioPulmonary bioImage Study (SCAPIS), 10 360 participants aged 50– 64 years underwent IOS and spirometry, and answered questionnaires on respiratory symptoms. Reference values were defined using healthy never-smoking participants. Abnormality was defined as <5th or >95th percentile, depending on the variable of interest. Results Abnormal IOS indices were found in 31%, 38%, 28% and 40% of individuals with obstructive spirometry, only PRISm, only RSP and PRISm+RSP, respectively. Abnormal indices in individuals with obstructive spirometry (forced expiratory volume in 1 s/forced vital capacity <5th percentile) were associated with respiratory symptoms, particularly wheeze (adjusted (a)OR 2.84, 95% CI 2.02–3.99). In PRISm, abnormal indices were associated with dyspnoea (aOR 2.82, 95% CI 1.13–7.02), whereas in RSP, they were linked to wheeze (aOR 11.3, 95% CI 3.63–35.1) and any respiratory symptom (aOR 2.18, 95% CI 1.07–4.44). Abnormal indices were associated with increased sick leave due to respiratory problems in the obstructive group and the PRISm+RSP group, with highest risk in the latter (aOR 2.69, 95% CI 1.22–5.92). Conclusion Abnormal IOS indices are common and can partially explain respiratory symptoms in individuals with altered spirometry patterns.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
ERJ open research
volume
11
issue
6
article number
00483-2025
publisher
European Respiratory Society
external identifiers
  • scopus:105026384828
  • pmid:41257186
ISSN
2312-0541
DOI
10.1183/23120541.00483-2025
language
English
LU publication?
yes
additional info
Publisher Copyright: © The authors 2025.
id
2e843923-29cc-436c-82c6-0390756c3d73
date added to LUP
2026-02-17 13:06:34
date last changed
2026-02-18 03:00:11
@article{2e843923-29cc-436c-82c6-0390756c3d73,
  abstract     = {{<p>Background Preserved ratio impaired spirometry (PRISm) and restrictive spirometry pattern (RSP) are associated with increased morbidity and mortality, but the underlying mechanisms are unclear. Impulse oscillometry (IOS) measures small airway function more sensitively than spirometry. We aim to study the prevalence of abnormal IOS findings in relation to three spirometry patterns (obstructive, PRISm and RSP), and their associations with respiratory symptoms. Methods In the Swedish CArdioPulmonary bioImage Study (SCAPIS), 10 360 participants aged 50– 64 years underwent IOS and spirometry, and answered questionnaires on respiratory symptoms. Reference values were defined using healthy never-smoking participants. Abnormality was defined as &lt;5th or &gt;95th percentile, depending on the variable of interest. Results Abnormal IOS indices were found in 31%, 38%, 28% and 40% of individuals with obstructive spirometry, only PRISm, only RSP and PRISm+RSP, respectively. Abnormal indices in individuals with obstructive spirometry (forced expiratory volume in 1 s/forced vital capacity &lt;5th percentile) were associated with respiratory symptoms, particularly wheeze (adjusted (a)OR 2.84, 95% CI 2.02–3.99). In PRISm, abnormal indices were associated with dyspnoea (aOR 2.82, 95% CI 1.13–7.02), whereas in RSP, they were linked to wheeze (aOR 11.3, 95% CI 3.63–35.1) and any respiratory symptom (aOR 2.18, 95% CI 1.07–4.44). Abnormal indices were associated with increased sick leave due to respiratory problems in the obstructive group and the PRISm+RSP group, with highest risk in the latter (aOR 2.69, 95% CI 1.22–5.92). Conclusion Abnormal IOS indices are common and can partially explain respiratory symptoms in individuals with altered spirometry patterns.</p>}},
  author       = {{Kjellberg, Sanna and Åhman, Ida and Färdig, Martin and Zaigham, Suneela and Frantz, Sophia and Engström, Gunnar and Janson, Christer and Wollmer, Per and Malinovschi, Andrei}},
  issn         = {{2312-0541}},
  language     = {{eng}},
  number       = {{6}},
  publisher    = {{European Respiratory Society}},
  series       = {{ERJ open research}},
  title        = {{Oscillometry findings in altered spirometry patterns and relationship to respiratory symptoms}},
  url          = {{http://dx.doi.org/10.1183/23120541.00483-2025}},
  doi          = {{10.1183/23120541.00483-2025}},
  volume       = {{11}},
  year         = {{2025}},
}